Aminopyrimidine derivatives as phosphatidylinositol phosphate kinase inhibitors

A compound of Formula (Id):

• or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, stereoisomer, or tautomer thereof, wherein
• X2 is C(R5) or N;
• W is C(R6);
• R1 is —N(R2)C(O)R3, —C(O)N(R2)(R3), —P(O)(R2)(R3), or heteroaryl, wherein the heteroaryl is optionally substituted with one or more R7;
• R2 is C1-6 alkyl;
• R3 is C1-6 alkyl or C3-8 cycloalkyl;
• or
• R2 and R3 when taken together with the atom to which they are each attached form a heterocycle optionally substituted with one or more R4;
• each R4 is independently —H or C1-6 alkyl;
• R5 is —H;
• R6 is —H, —N(R26)(R27), C1-6 alkoxy, heterocyclyl, C2-6 alkenyl, C1-6 haloalkyl, or C1-6 alkyl, wherein the C1-6 alkyl, C2-6 alkenyl, C1-6 alkoxy, or heterocyclyl is optionally substituted with one or more —OH, —CN, C1-6 alkyl, or heterocyclyl;
• each R7 is independently C1-6 alkyl;
• R15 is —N(C1-6 alkyl)2, C1-6 alkyl, —C(O)N(R21)(R23), —(CH2)o—C(O)R23, or —C(O)OR23, wherein the C1-6 alkyl is optionally substituted with one or more R23;
• R21 is —H or C1-6 alkyl;
• each R23 is independently C1-6 alkyl optionally substituted with one or more —N(C1-6 alkyl)2;
• or
• two R23 when taken together with the atom to which they are each attached form a heterocyclyl, wherein the heterocyclyl is optionally substituted by C1-6 alkyl;
• R26 is —H or C1-6 alkyl;
• R27 is C1-6 alkyl, heterocyclyl, or cycloalkyl, wherein the C1-6 alkyl, heterocyclyl, or cycloalkyl is optionally substituted with one or more halogen, —CN, —C(O)OH, —OH, or —NH2;
• and
• o is 0-4.