# US 12,006,310 B2 · Preparation and application of triterpenoids with effect of improving glucose and lipid metabolism disorders

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- Number: US 12,006,310 B2
- Document ID: US12006310B2
- Status: Granted
- Kind: B2
- Application number: 17/855,823
- Filed: 2022-07-01
- Published: 2023-01-26
- Granted: 2024-06-11
- Earliest claimed: 2022-07-01
- Assignees: Sericultural & Agri-Food Research Institute Guangdong Academy of Agriculteral Sciences
- Applicants: Sericultural&Agri-Food Research Institute Guangdong Academy of Agricultural Sciences
- Inventors: Mingwei Zhang; Yuanyuan Deng; Guang Liu; Yan Zhang; Zhencheng Wei; Pengfei Zhou; Ping Li; Zhihao Zhao; Xuchao Jia; Xiaojun Tang
- Web page: https://patentgrep.com/patent/US12006310B2

## CPC

- C07D 407/12: linked by a chain containing hetero atoms as chain links
- A61K 36/42: Cucurbitaceae (Cucumber family)
- C07J 71/0005: {Oxygen-containing hetero ring}
- A61K 2236/00: Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07J: STEROIDS (seco-steroids C07C)

## Abstract

The present invention relates to the technical field of natural medicines, and in particular to a triterpenoid compound with an effect of improving glucose and lipid metabolism disorders, and preparation and application thereof. A novel triterpenoid compound was obtained by separation from Momordica charantia L. for the first time in the present invention. Studies on a mouse primary hepatocyte model and a 3T3-L1 preadipocyte model show that the novel triterpenoid compound in the present invention has activity of regulating glucose and lipid metabolism, and after combination with known triterpenoid compound Momordicoside G, the activity of regulating glucose and lipid metabolism is significantly higher than that of a single compound at the same dose, indicating that the novel triterpenoid compound and a complex thereof in the present invention can be used to improve glucose and lipid metabolism disorders and provide a new way for diabetes treatment.

## Claims

### Claim 1

A drug for treatment of diabetes, comprising a triterpenoid having a structure shown in formula (I) and a triterpenoid compound Momordicoside G,
wherein the mass ratio of the triterpenoid compound of formula (I) to the triterpenoid compound Momordicoside G is 1:(0.5-1.5).

### Claim 2 (depends on 1)

The drug for treatment of diabetes according to claim 1, wherein the mass ratio of the triterpenoid compound of formula (I) to the triterpenoid compound Momordicoside G is 1:0.5, 1:1.0, or 1:1.5.