Polymorphic compounds and uses thereof

A crystalline compound selected from one of the following:

• compound 2:
• of Forms A, having one or more peaks in its XRPD selected from those at 8.1±0.2, 10.6±0.2, 11.1±0.2, 13.5±0.2, 13.6±0.2, 15.8±0.2, 16.4±0.2, 16.7±0.2, 17.8±0.2, 18.7±0.2, 19.0±0.2, 19.3±0.2, 21.4±0.2, 21.5±0.2, 22.0±0.2, 22.2±0.2, 24.1±0.2, 24.3±0.2, 26.1±0.2, and 26.52±0.2° 2θ;
• or
• Form B, having one or more peaks in its XRPD selected from those at 6.0±0.2, 8.1±0.2, 9.6±0.2, 10.8±0.2, 11.1±0.2, 13.4±0.2, 15.0±0.2, 16.0±0.2, 16.6±0.2, 17.3±0.2, 18.1±0.2, 18.9±0.2, 19.4±0.2, 19.9±0.2, 20.8±0.2, 21.3±0.2, 23.5±0.2, 24.6±0.2, 25.9±0.2, and 29.3±0.2° 2θ;
• or
• Form C, having one or more peaks in its XRPD selected from those at 6.1±0.2, 8.7±0.2, 12.2±0.2, 12.4±0.2, 13.8±0.2, 15.1±0.2, 16.1±0.2, 16.7±0.2, 18.2±0.2, 18.9±0.2, 19.1±0.2, 20.2±0.2, 21.3±0.2, 21.6±0.2, 21.8±0.2, 21.9±0.2, 23.5±0.2, 24.5±0.2, 25.2±0.2, and 27.9±0.2° 2θ;
• compound 3:
• of Form A, having one or more peaks in its XRPD selected from those at 7.8±0.2, 10.3±0.2, 11.6±0.2, 11.8±0.2, 12.7±0.2, 13.2±0.2, 15.6±0.2, 16.8±0.2, 18±0.2, 19.4±0.2, 20.4±0.2, 21.8±0.2, 22.8±0.2, 23.6±0.2, 23.9±0.2, 24.4±0.2, 24.6±0.2, 25.2±0.2, 26.3±0.2, and 26.7±0.2° 2θ;
• or
• Form B, having one or more peaks in its XRPD selected from those at 6.0±0.2, 11.6±0.2, 11.9±0.2, 12.8±0.2, 12.9±0.2, 15.3±0.2, 15.7±0.2, 16.2±0.2, 16.4±0.2, 18.0±0.2, 19.3±0.2, 19.9±0.2, 20.3±0.2, 21.5±0.2, 22.0±0.2, 22.6±0.2, 23.8±0.2, 24.7±0.2, 25.4±0.2, and 26.3±0.2° 2θ;
• or
• Form C, having one or more peaks in its XRPD selected from those at 3.3±0.2, 8.3±0.2, 12.8±0.2, 14.7±0.2, 15.5±0.2, 16.1±0.2, 16.6±0.2, 17.8±0.2, 19.5±0.2, 20.0±0.2, 20.2±0.2, 22.2±0.2, 23.8±0.2, 24.2±0.2, 25.0±0.2, 25.5±0.2, 26.1±0.2, 27.2±0.2, 28.1±0.2, and 29.7±0.2° 2θ;
• compound 4:
• of Form A, having one or more peaks in its XRPD selected from those at 5.6±0.2, 10.5±0.2, 11.0±0.2, 11.2±0.2, 11.4±0.2, 12.9±0.2, 14.4±0.2, 18.4±0.2, 18.6±0.2, 19.6±0.2, 19.9±0.2, 20.5±0.2, 20.7±0.2, 22.7±0.2, 23.0±0.2, 23.8±0.2, 25.2±0.2, 25.3±0.2, 28.4±0.2, and 29.3±0.2° 2θ;
• compound 5:
• of Form A, having one or more peaks in its XRPD selected from those at 8.1±0.2, 11.7±0.2, 13.0±0.2, 13.6±0.2, 13.9±0.2, 15.4±0.2, 16.0±0.2, 16.7±0.2, 19.6±0.2, 20.0±0.2, 20.2±0.2, 20.5±0.2, 23.0±0.2, 24.1±0.2, 24.5±0.2, 25.4±0.2, 26.8±0.2, 27.3±0.2, 30.3±0.2, and 32.5±0.2° 2θ;
• or
• Form B, having one or more peaks in its XRPD selected from those at 7.4±0.2, 8.4±0.2, 13.4±0.2, 13.7±0.2, 14.3±0.2, 14.8±0.2, 15.0±0.2, 18.8±0.2, 20.2±0.2, 20.4±0.2, 21.3±0.2, 23.1±0.2, 23.8±0.2, 24.3±0.2, 24.7±0.2, 25.1±0.2, 26.7±0.2, 27.5±0.2, 27.6±0.2, and 32.2±0.2° 2θ;
• or
• Form C, having one or more peaks in its XRPD selected from those at 12.2±0.2, 13.4±0.2, 14.1±0.2, 16.8±0.2, 17.6±0.2, 19.5±0.2, 20.4±0.2, 20.8±0.2, 22.4±0.2, 22.6±0.2, 24.3±0.2, 25.0±0.2, 25.8±0.2, 26.6±0.2, 27.0±0.2, 27.9±0.2, 28.5±0.2, 28.7±0.2, and 30.1±0.2° 2θ;
• compound 6:
• of Form A, having one or more peaks in its XRPD selected from those at 6.4±0.2, 10.6±0.2, 12.4±0.2, 14.0±0.2, 15.2±0.2, 16.0±0.2, 14.4±0.2, 16.7±0.2, 17.1±0.2, 18.0±0.2, 19.4±0.2, 20.3±0.2, 22.3±0.2, 24.9±0.2, 26.2±0.2, 27.1±0.2, 27.4±0.2, 28.2±0.2, 30.7±0.2, 32.1±0.2, and 32.6±0.2° 2θ;
• compound 7:
• of Form A, having one or more peaks in its XRPD selected from those at 5.9±0.2, 11.7±0.2, 12.2±0.2, 13.2±0.2, 14.0±0.2, 14.3±0.2, 16.4±0.2, 17.2±0.2, 17.7±0.2, 21.6±0.2, 22.2±0.2, 22.7±0.2, 24.1±0.2, 24.5±0.2, 24.9±0.2, 26.4±0.2, 26.6±0.2, 27.3±0.2, and 32.8±0.2° 2θ;
• or
• Form B, having one or more peaks in its XRPD selected from those at 6.0±0.2, 12.1±0.2, 12.6±0.2, 12.9±0.2, 13.2±0.2, 13.4±0.2, 15.3±0.2, 15.9±0.2, 16.6±0.2, 18.2±0.2, 19.4±0.2, 20.2±0.2, 22.3±0.2, 23.0±0.2, 23.3±0.2, 24.3±0.2, 24.6±0.2, 23.5±0.2, 27.4±0.2, and 30.8±0.2° 2θ;
• or
• Form C, having one or more peaks in its XRPD selected from those at 5.5±0.2, 11.1±0.2, 11.4±0.2, 13.6±0.2, 13.9±0.2, 16.0±0.2, 16.6±0.2, 17.7±0.2, 17.9±0.2, 19.2±0.2, 20.6±0.2, 21.3±0.2, 22.1±0.2, 23.4±0.2, 25.2±0.2, 26.4±0.2, 27.4±0.2, 28.1±0.2, 31.2±0.2, and 33.5±0.2° 2θ;
• compound 8:
• of Form A, having one or more peaks in its XRPD selected from those at 5.5±0.2, 10.6±0.2, 11.1±0.2, 12.4±0.2, 12.8±0.2, 13.0±0.2, 14.5±0.2, 15.6±0.2, 17.0±0.2, 18.2±0.2, 20.8±0.2, 21.7±0.2, 22.4±0.2, 24.4±0.2, 24.9±0.2, 25.1±0.2, 25.3±0.2, 25.7±0.2, 26.4±0.2, and 26.7±0.2° 2θ;
• or
• Form B, having one or more peaks in its XRPD selected from those at 5.0±0.2, 5.5±0.2, 10.6±0.2, 11.0±0.2, 11.2±0.2, 11.8±0.2, 13.0±0.2, 14.0±0.2, 14.3±0.2, 16.5±0.2, 16.9±0.2, 17.9±0.2, 18.2±0.2, 19.9±0.2, 20.5±0.2, 22.3±0.2, 24.3±0.2, 26.3±0.2, 28.9±0.2, and 30.1±0.2° 2θ;
• compound 9:
• of Form A, having one or more peaks in its XRPD selected from those at 3.4±0.2, 6.8±0.2, 10.2±0.2, 11.6±0.2, 13.0±0.2, 14.1±0.2, 16.9±0.2, 17.3±0.2, 19.1±0.2, 20.5±0.2, 22.3±0.2, 22.6±0.2, 24.2±0.2, 26.1±0.2, 30.4±0.2, 30.5±0.2, 30.9±0.2, 32.4±0.2, 32.5±0.2, and 33.1±0.2° 2θ;
• compound 10:
• of Form A, having one or more peaks in its XRPD selected from those at 11.6±0.2, 14.8±0.2, 15.2±0.2, 16.6±0.2, 17.3±0.2, 17.9±0.2, 19.5±0.2, 19.6±0.2, 19.7±0.2, 21.7±0.2, 22.8±0.2, 23.3±0.2, 23.5±0.2, 23.7±0.2, 25.5±0.2, 28.1±0.2, 28.7±0.2, 28.8±0.2, 31.1±0.2, and 32.3±0.2° 2θ;
• compound 11:
• of Form A, having one or more peaks in its XRPD selected from those at 5.6±0.2, 10.9±0.2, 11.1±0.2, 12.0±0.2, 12.9±0.2, 13.7±0.2, 15.8±0.2, 16.5±0.2, 16.7±0.2, 17.8±0.2, 20.0±0.2, 21.6±0.2, 22.5±0.2, 24.2±0.2, 24.4±0.2, 24.7±0.2, 26.8±0.2, 28.4±0.2, 32.4±0.2, and 33.3±0.2° 2θ;
• and
• compound 12:
• of Form A, having one or more peaks in its XRPD selected from those at 5.6±0.2, 11.2±0.2, 13.0±0.2, 16.7±0.2, 16.8±0.2, 16.9±0.2, 17.4±0.2, 17.6±0.2, 18.1±0.2, 19.3±0.2, 21.4±0.2, 21.8±0.2, 22.2±0.2, 23.8±0.2, 24.5±0.2, 26.2±0.2, 26.9±0.2, 27.3±0.2, 27.6±0.2, and 28.4±0.2° 2θ.