# US 12,005,434 B2 · Pipetting device, pipette tip coupler, and pipette tip: devices and methods

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- Number: US 12,005,434 B2
- Document ID: US12005434B2
- Status: Granted
- Kind: B2
- Application number: 17/481,728
- Filed: 2021-09-22
- Published: 2022-01-27
- Granted: 2024-06-11
- Earliest claimed: 2016-06-15
- Assignees: Hamilton Company
- Applicants: Hamilton Company
- Inventors: Jose Eduardo Guzman; Thomas Barresi; Dana A. Belton
- Web page: https://patentgrep.com/patent/US12005434B2

## CPC

- B01L 3/0279: {co-operating with positive ejection means}
- B01L 3/0217: {of the plunger pump type}
- B01L 3/0275: {Interchangeable or disposable dispensing tips}
- B01L 3/563: {Joints or fittings; Separable fluid transfer means to transfer fluids between at least two containers, e.g. connectors}
- B01L 9/543: {for disposable pipette tips, e.g. racks or cassettes}
- G01N 35/10: Devices for transferring samples {or any liquids} to, in, or from, the analysis apparatus, e.g. suction devices, injection devices {(G01N35/0099 takes precedence)}
- B01L 2200/02: Adapting objects or devices to another
- B01L 2200/021: Adjust spacings in an array of wells, pipettes or holders, format transfer between arrays of different size or geometry
- B01L 2200/023: adapted for different sizes of tubes, tips or container
- B01L 2200/025: Align devices or objects to ensure defined positions relative to each other
- B01L 2200/026: Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L 2200/04: Exchange or ejection of cartridges, containers or reservoirs
- B01L 2200/0689: Sealing
- B01L 2300/0832: cylindrical, tube shaped
- B01L 2300/123: Flexible; Elastomeric
- G01N 35/1011: {Control of the position or alignment of the transfer device}
- G01N 2035/1025: {Fluid level sensing}
- G01N 2035/103: {using disposable tips}
- B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

Pipette tip couplers, pipette tips, coupler and tip combinations, and methods for coupling and decoupling a pipette tip to or from, respectively, a pipette tip coupler mounted on a pipette device, are disclosed. The pipette tip couplers include an elastomeric element and an annular ring shaped raceway. When the pipette tip is mounted on the pipette tip coupler, the annular ring shaped raceway abuts a first portion of the interior surface of the circumscribing sidewall of the pipette tip, and the elastomeric element abuts a second portion of the interior surface of the circumscribing sidewall of the pipette tip.

## Claims

### Claim 1

A method for securing attachment of a pipette tip to a pipette tip coupling device carried by a pipette device, the method comprising:
providing a pipette tip coupler coupled to a pipette device, the pipette tip coupler comprising:
a shank;
a coupler body distal to the shank;
a distal stem portion;
a distal end plate;
an open-ended interior circumscribing surface forming an open passageway extending longitudinally from the proximal end face through the distal end plate;
an elastomeric element disposed around the distal stem portion and adjacent to the distal end plate; and
a pipette tip ball assembly circumscribing the shank comprising:
a plurality of spherical balls; and
a ring-shaped raceway body comprising:
a plurality of circumferentially spaced apart guide sockets for carrying the plurality of spherical balls; and
a plurality of circumferentially spaced apart circular ball openings for receiving and retaining the plurality of spherical balls; and
an annular wedge;
providing a pipette tip comprising a circumscribing sidewall with an open interior passage including an interior surface and extending along a central longitudinal axis of the pipette tip between an open proximal end and an open distal end of the pipette tip;
locating the pipette tip coupling device over the open proximal end of the pipette tip with an axial alignment between a central longitudinal axis of the pipette tip coupler and the central longitudinal axis of the pipette tip;
inserting the pipette tip coupler through the open proximal end of the pipette tip leading with the distal end plate of the pipette tip coupler; and
applying a mechanical force against the annular wedge to push each of the plurality of spherical balls radially outward along one of the plurality of circumferentially spaced apart guide sockets to abut the plurality of spherical balls against a first portion of the interior surface of the circumscribing sidewall of the pipette tip for securing the pipette tip to the pipette tip coupling device and to abut the elastomeric element against a second portion of the interior surface of the circumscribing sidewall of the pipette tip to form a seal between the pipette tip coupling device and the pipette tip.