# US 12,005,173 B2 · Extracorporeal circuit and column design therefore

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- Number: US 12,005,173 B2
- Document ID: US12005173B2
- Status: Granted
- Kind: B2
- Application number: 16/763,645
- Filed: 2018-11-16
- Published: 2020-11-12
- Granted: 2024-06-11
- Earliest claimed: 2017-11-16
- Assignees: Immutrix Therapeutics, Inc.
- Applicants: Immutrix Therapeutics, Inc.
- Inventors: Todd Goodrich; Ryan McGivern; Rob Moyers
- Web page: https://patentgrep.com/patent/US12005173B2

## CPC

- A61M 1/3621: {Extra-corporeal blood circuits (single-needle circuits A61M1/30)}
- A61M 1/3679: {by absorption (A61M1/3675 takes precedence)}
- A61M 1/3626: {Gas bubble detectors}
- A61M 2205/3331: Pressure; Flow
- A61M 2206/12: the flow being spirally in a plane, e.g. against a plane side of a membrane filter element
- A61M 2206/16: Rotating swirling helical flow, e.g. by tangential inflows
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

Systems and methods for the treatment of a bodily fluid, for example, using a cartridge that may include a cartridge body configured to retain an adsorptive material and an end segment configured to cover a first end of the cartridge body. The end segment may include a circular face comprising an outwardly truncated conical shape and defining an internal conical space, a cylindrical wall joined to a periphery of the circular face, and an inlet configured to provide fluid connection to a source of the bodily fluid. The inlet may be disposed tangential to the circular face at the cylindrical wall so as to direct bodily fluid entering the cartridge into the internal conical space tangentially so as to decelerate the bodily fluid within the internal conical space prior to contact with the adsorptive material disposed within the cartridge body.

## Claims

### Claim 1

A method of removing one or more components present in bodily fluid to produce a decontaminated bodily fluid, the method comprising:
attaching a cartridge to an input for bodily fluid;
attaching the cartridge to an output for a decontaminated bodily fluid from the cartridge;
passing bodily fluid through the cartridge, wherein the cartridge comprises:
a cartridge body configured to retain an adsorptive material; and
an end segment configured to cover a first end of the cartridge body, the end segment comprising:
a circular face comprising an outwardly truncated conical shape and defining an internal conical space;
a cylindrical wall joined to a periphery of the circular face; and
an inlet configured to provide fluid connection to a source of the bodily fluid, wherein the inlet comprises a central axis that is perpendicular to a longitudinal axis of the end segment, wherein the inlet is (1) disposed tangential to the circular face at the cylindrical wall so as to (i) direct bodily fluid entering the cartridge into the internal conical space tangentially so as to decelerate the bodily fluid within the internal conical space prior to contact with the adsorptive material disposed within the cartridge body, and (ii) cause the bodily fluid to enter the cartridge substantially perpendicular to a flow direction of the bodily fluid through the adsorptive material and (2) configured to utilize gravity to assist the bodily fluid with contacting the adsorptive material; and
filtering one or more substances from the bodily fluid to produce the decontaminated bodily fluid.

### Claim 2 (depends on 1)

The method of claim 1, further comprising establishing a fluid connection between a pump and at least one of the input or the output of the cartridge.

### Claim 3 (depends on 2)

The method of claim 2, further comprising pumping, via the pump, the bodily fluid through the cartridge.

### Claim 4 (depends on 1)

The method of claim 1, further comprising measuring, via level detector, the cartridge pressure.

### Claim 5 (depends on 1)

The method of claim 1, further comprising drawing the bodily fluid from a subject; and allowing the decontaminated bodily fluid to flow back to the subject.