# US 12,005,167 B2 · Method and devices for the calibration of a pump for the blood treatment > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,005,167 B2 - Document ID: US12005167B2 - Status: Granted - Kind: B2 - Application number: 16/630,074 - Filed: 2018-07-06 - Published: 2020-11-12 - Granted: 2024-06-11 - Earliest claimed: 2017-07-10 - Assignees: Fresenius Medical Care Deutschland GmbH - Applicants: Fresenius Medical Care Deutschland GmbH - Inventors: Josef Beden; Juergen Klewinghaus - Web page: https://patentgrep.com/patent/US12005167B2 ## CPC - A61M 1/1601: {Control or regulation} - A61M 1/14: Dialysis systems; Artificial kidneys; Blood oxygenators (semi-permeable membranes characterised by the material, manufacturing processes therefor B01D71/00){; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis} - A61M 1/16: with membranes - A61M 1/1615: {using measurements made at different flow rates} - A61M 1/1617: {using measurements made during a temporary variation of a characteristic of the fresh dialysis fluid} - A61M 1/34: Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration - A61M 1/3621: {Extra-corporeal blood circuits (single-needle circuits A61M1/30)} - A61M 1/3644: {Mode of operation} - A61M 1/3649: {using dialysate as priming or rinsing liquid} - A61M 1/365: {through membranes, e.g. by inverted trans-membrane pressure [TMP]} - A61M 60/113: in other functional devices, e.g. dialysers or heart-lung machines - A61M 60/279: Peristaltic pumps, e.g. roller pumps - A61M 60/37: Haemodialysis, haemofiltration or diafiltration - A61M 60/422: the force acting on the blood contacting member being electromagnetic, e.g. using canned motor pumps - A61M 60/50: Details relating to control - A61M 60/546: of blood flow, e.g. by adapting rotor speed - A61M 60/833: Occluders for preventing backflow - A61M 1/362264: {the filter being a blood filter} - A61M 2205/3393: by weighing the reservoir - A61M 2205/70: with testing or calibration facilities - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract The present disclosure relates to a method for determining an actual pump rate and/or for calibrating a blood pump of a blood treatment apparatus connected to an extracorporeal blood circuit. The method includes providing a blood pump of a blood treatment apparatus or establishing a signal communication to a blood pump. The blood pump comprises, or is connected to at least a first source for a fluid and at least a first line of an extracorporeal blood circuit which is connected to the first source downstream. Furthermore, the blood pump comprises, or is connected to, a reception unit for receiving fluids of the first source wherein the reception unit is in fluid communication with the first line. The reception unit is arranged on or at a first weighing device such that the weight of the reception unit or of its content is determined using the weighing device. ## Claims ### Claim 1 A method for determining an actual pump rate or for calibrating a blood pump of a blood treatment apparatus connected to an extracorporeal blood circuit, the method comprising: providing a blood pump of a blood treatment apparatus, or establishing a signal connection to a blood pump, the blood pump connected to comprising: at least a first fluid source; at least a first line of an extracorporeal blood circuit which is connected downstream to the first fluid source; and at least one reception unit for receiving fluid of the first fluid source, wherein the reception unit is in fluid communication with the first line, wherein the reception unit is arranged on or at a first weighing device such that a weight of at least one of the reception unit or of a content of the reception unit is determinable via the first weighing device; setting a value for a pump rate being adjustable at the blood pump as a set pump rate, or transmitting such a value to the blood pump as a set pump rate; operating the blood pump at the set pump rate during a conveyance time period such that the fluid from the first fluid source is conveyed as actual volume through the first line into the reception unit; determining via the first weighing device an actual volume conveyed during the conveyance time period based on a change of the weight of the reception unit or of the contents of the reception unit; and determining a mathematical relation between the actual volume and a target volume, the target volume resulting from the conveyance time period and the set pump rate; wherein the blood treatment apparatus is configured to maintain a particular pressure within the first line before the conveyance time period and to maintain the particular pressure within the first line after the conveyance time period. ### Claim 2 (depends on 1) The method according to claim 1, wherein the method further comprises: determining a relation between the set pump rate and an actual pump rate, wherein the actual pump rate is determined considering the actual volume and the conveyance time period. ### Claim 3 (depends on 2) The method according to claim 2, wherein the method further comprises: defining a correction factor or calibration factor for the blood pump based on the relation between the pump rate set at the blood pump and the actual pump rate or based on the actual volume and the target volume. ### Claim 4 (depends on 2) The method according to claim 2, wherein the method further comprises: defining a correction factor or calibration factor for the blood pump based on the relation between the pump rate set at the blood pump and the actual pump rate and based on the actual volume and the target volume. ### Claim 5 (depends on 1) The method according to claim 1, wherein: the blood treatment apparatus is configured to maintain the particular pressure within the first line during the conveyance time period. ### Claim 6 (depends on 1) The method according to claim 1, wherein the extracorporeal blood circuit comprises, or is connected to, a blood filter or a dialyzer that comprises a semi-permeable membrane. ### Claim 7 (depends on 6) The method according to claim 6, wherein the reception unit is in fluid communication with the first line downstream of the blood filter or the dialyzer. ### Claim 8 (depends on 6) The method according to claim 6, wherein the reception unit is in fluid communication with the first line downstream of the blood filter or the dialyzer and through the semi-permeable membrane of the dialyzer. ### Claim 9 (depends on 6) The method according to claim 6, wherein the blood filter or the dialyzer is connected to a dialysis liquid inlet line and a dialysate line, wherein at least one of a check valve and an occluding pump is integrated in the dialysis liquid inlet line to prevent an undesired flow in direction against a flow direction of the dialysis liquid inlet line and/or in direction away from the blood filter. ### Claim 10 (depends on 6) The method according to claim 6, wherein the blood filter or the dialyzer is in fluid communication with an arterial patient line and with a venous patient line, wherein a tube clamp is arranged in or at the venous patient line, wherein the method further comprises: closing the tube clamp at the venous patient line during the conveyance time period. ### Claim 11 (depends on 1) The method according to claim 1, wherein the blood pump and an effluent pump each convey at a same pump rate during the conveyance time period. ### Claim 12 (depends on 11) The method according to claim 11, wherein: the blood treatment apparatus is configured to maintain the particular pressure within the first line during the conveyance time period. ### Claim 13 (depends on 1) The method according to claim 1, wherein in order to maintain the particular pressure within the first line, an effluent pump is rotated by a control or closed-loop device, in a pressure-controlled manner. ### Claim 14 (depends on 1) The method according to claim 1, wherein the fluid is a saline solution, a dialysis liquid, a substituate, or a priming liquid. ### Claim 15 (depends on 1) The method according to claim 1 further comprising: providing the blood treatment apparatus as or being a hemodialysis apparatus, hemofiltration apparatus, or hemodiafiltration apparatus.