# US 12,005,128 B1 · Near infrared small molecule probes for the detection of cellular senescence

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 12,005,128 B1
- Document ID: US12005128B1
- Status: Granted
- Kind: B1
- Application number: 16/838,907
- Filed: 2020-04-02
- Granted: 2024-06-11
- Earliest claimed: 2019-04-02
- Assignees: UNM Rainforest Innovations
- Applicants: Lina Cui; Jun Liu; Xiaowei Ma; Ying Wang; Philip Deenik
- Inventors: Lina Cui; Jun Liu; Xiaowei Ma; Ying Wang; Philip Deenik
- Web page: https://patentgrep.com/patent/US12005128B1

## CPC

- A61K 49/0043: {Fluorescein, used in vivo}
- A61K 49/0041: {Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal (in vivo G01N)}
- A61K 49/0052: {Small organic molecules (oligomers, polymers, dendrimers A61K49/0054)}
- A61K 49/0058: {Antibodies}
- C07H 17/04: Heterocyclic radicals containing only oxygen as ring hetero atoms
- C09B 23/105: {two >CH- groups}
- G01N 33/582: {with fluorescent label}
- C07D 491/052: the oxygen-containing ring being six-membered
- G01N 2458/00: Labels used in chemical analysis of biological material
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07H: SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS (derivatives of aldonic or saccharic acids C07C, C07D; aldonic acids, saccharic acids C07C59/105, C07C59/285; cyanohydrins C07C255/16; glycals C07D; compounds of unknown constitution C07G; polysaccharides, derivatives thereof C08B; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; sugar industry C13)
- C09B: ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES {, e.g. PIGMENTS}; MORDANTS; LAKES (fermentation or enzyme using processes to synthesise a desired chemical compound C12P)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

A probe comprising a biomarker-triggered moiety, a near infrared (NIR) fluorophore reporter, a self-immolative linker and a self-immobilizing moiety for visualization of senescent cells and methods of use thereof.

## Claims

### Claim 1

A probe for visualization of senescent cells wherein the probe has the chemical structure:
where R is CHF2.

### Claim 2

A method for detecting or visualizing cell senescence comprising delivering to one or more cells a senescence visualizing probe having the chemical structure:
where R is CHF2.

### Claim 3 (depends on 2)

The method of claim 2 wherein the cells are in vivo.