Compositions for oral administration of pentosan polysulfate in form of nanoparticles with improved intestinal absorption
AssigneeAlmira Pharma Srl
InventorsAdolfo Gasparetto, Fabio Borella, Viviana Mascilongo, Ruggero Bettini, Fabio Sonvico, Marta Cito
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Abstract
The present invention relates to pharmaceutical composition for the oral delivery of Pentosan Polysulfate sodium (PPS). In particular, the invention discloses compositions of PPS in form of nanoparticles with a suitable polymer aimed to improve the PPS absorption in the small intestine and reduce or eliminate the side effects in the colon.
Claims3
An Oral Composition comprising nanoparticles of a complex of Pentosan Polysulfate sodium with chitosan, wherein the nanoparticles have a diameter between 80 and 220 nm and wherein the chitosan has a degree of deacetylation between 78 and 99% and molecular weight between 30 and 400 kDa.
Dependencies are inferred from the claim text.