Compounds and methods for diagnosis and treatment of viral infections
AssigneeNavidea Biopharmaceuticals, Inc.
InventorsFrederick O. Cope, David A. Ralph
Life of this patent
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Abstract
Compositions and methods of using these compositions that can include a targeting moiety and a therapeutic agent are described herein. These compositions can be used for diagnosing and/or treating flaviviridae—family viruses including Zika virus, dengue virus, and yellow fever.
Claims20
A method of treating a disease caused by infection by a flaviviridae family virus comprising administering to a subject in need thereof an effective amount of a compound of Formula (II):
- wherein each X is independently H, L1-A, or L2-R;
- each L1 and L2 are independently linkers;
- each A independently comprises a therapeutic agent or a detection label or H;
- each R independently comprises a CD206 targeting moiety or H;
- and
- n is an integer greater than zero;
- wherein at least one R is a CD206 targeting moiety and at least one A is a chemotherapeutic agent.
A method of targeting a flaviviridae family virus by targeting macrophages comprising administering to a subject in need thereof an effective amount of a compound of Formula (II):
- wherein each X is independently H, L1-A, or L2-R;
- each L1 and L2 are independently linkers;
- each A independently comprises a therapeutic agent or a detection label or H;
- each R independently comprises a CD206 targeting moiety or H;
- and
- n is an integer greater than zero;
- wherein at least one R is a CD206 targeting moiety and at least one A is a chemotherapeutic agent to treat the disease and decrease the amount of disease-causing virus.
A method of treating a disease caused by infection by a flaviviridae family virus comprising administering to a subject in need thereof an effective amount of compound comprising a dextran backbone having one or more CD206 targeting moieties and one or more chemotherapeutic agents attached thereto.
Dependencies are inferred from the claim text.