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AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsMasaru Kanekiyo, Gary J. Nabel, Jeffrey Cohen, Wei Bu
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Vaccines are provided that elicit neutralizing antibodies to Epstein-Barr virus (EBV). Some vaccines comprise nanoparticles that display envelope proteins from EBV on their surface. The nanoparticles comprise fusion proteins comprising a monomeric subunit of a self-assembly protein, such as ferritin, joined to at least a portion of an EBV envelope protein. The fusion proteins self-assemble to form the envelope protein-displaying nanoparticles. Such vaccines can be used to vaccinate an individual against infection by different types of Epstein-Barr viruses as well as Epstein-Barr viruses that are antigenically divergent from the virus from which the EBV envelope protein was obtained. Also provided are fusion proteins and nucleic acid molecules encoding such proteins.
A nucleic acid molecule encoding a recombinant protein, the recombinant protein comprising at least 25 contiguous amino acids from a monomeric subunit protein capable of self-assembling to form a nanoparticle, joined to at least one immunogenic portion from a first Epstein-Barr Virus (EBV) envelope protein is gp350,
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