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US 12,005,099 B2Granted
Targeted antimicrobials and related compositions, methods and systems
AssigneeLawrence Livermore National Security, LLC
InventorsPaul J. Jackson, Brian E. Souza, Feliza A. Bourguet, Matthew A. Coleman
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Abstract
Targeted antimicrobials are described and related, compositions, methods and systems.
Claims18
An antimicrobial composition comprising
- a therapeutically effective antimicrobial amount of a targeted antimicrobial protein for Bacillus cereus or a microorganism related thereto and a suitable vehicle, the therapeutically effective antimicrobial amount being at least twice the amount produced in a cell of the Bacillus cereus or the microorganism related thereto,
- wherein the targeted antimicrobial protein has a catalytic domain and a binding domain, the targeted antimicrobial protein being BCZK2532 protein having SEQ ID NO:3 and/or a related lysin protein,
- wherein the related lysin protein has at least 90% identity with the BCZK2532 protein having SEQ ID NO:3 or a portion thereof having a lytic activity, and
- wherein the related lysin protein has an arginine in a position corresponding upon alignment to amino acid residue 100 of SEQ ID NO:3.
1 more element
An antimicrobial system comprising:
- a therapeutically effective antimicrobial amount of one or more targeted antimicrobial proteins specific for Bacillus cereus or one or more related microorganisms, the therapeutically effective antimicrobial amount being at least twice the amount produced in a cell of the Bacillus cereus or the microorganism related thereto,
- and at least one of
- suitable reagents, and
- an additional antimicrobial,
- wherein the one or more targeted antimicrobial proteins comprise BCZK2532 protein having SEQ ID NO:3 and/or one or more related lysin proteins
- wherein the one or more related lysin proteins have at least 90% identity with the BCZK2532 protein having SEQ ID NO:3 or a portion thereof having a lytic activity, and
- wherein the one or more related lysin proteins have an arginine in a position corresponding upon alignment to amino acid residue 100 of SEQ ID NO:3.
4 more elements
Dependencies are inferred from the claim text.