# US 12,005,096 B2 · Apoaequorin and vitamin d-containing compositions and methods of using same

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- Number: US 12,005,096 B2
- Document ID: US12005096B2
- Status: Granted
- Kind: B2
- Application number: 17/119,075
- Filed: 2020-12-11
- Published: 2021-06-10
- Granted: 2024-06-11
- Earliest claimed: 2016-09-23
- Assignees: Quincy Bioscience, LLC
- Applicants: Quincy Bioscience, LLC
- Inventors: Mark Y. Underwood
- Web page: https://patentgrep.com/patent/US12005096B2

## CPC

- A61K 38/1767: {from invertebrates}
- A23L 33/155: Vitamins A or D
- A23L 33/17: Amino acids, peptides or proteins
- A61K 9/48: Preparations in capsules, e.g. of gelatin, of chocolate {(A61K9/0004 takes precedence; bite capsules A61K9/0056)}
- A61K 31/593: 9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
- A61P 3/02: Nutrients, e.g. vitamins, minerals
- A61P 19/08: for bone diseases, e.g. rachitism, Paget's disease
- A61P 25/02: for peripheral neuropathies
- A61P 25/18: Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A23V 2200/00: Function of food ingredients
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

Compositions containing apoaequorin and vitamin D and methods for their use in treating symptoms and disorders related to calcium imbalances and vitamin D deficiency associated with, for example, sleep quality, energy quality, mood quality, memory quality or pain are provided by the present invention.

## Claims

### Claim 1

A composition for treating a symptom or disorder related to cell death following ischemia comprising:
(a) a therapeutically effective amount of apoaequorin;
(b) a therapeutically effective amount of vitamin D; and
(c) an acceptable carrier
wherein the therapeutically effective amount of apoaequorin is about 10 mg to 50 mg and the therapeutically effective amount of vitamin D is about 25 mcg to about 75 mcg.

### Claim 2 (depends on 1)

The composition according to claim 1, wherein the composition is in the form of a unit dosage containing said effective amounts of the apoaequorin and vitamin D.

### Claim 3 (depends on 2)

The composition according to claim 2, wherein: (a) the effective amount of apoaequorin in the unit dosage is about 20 mg; and (b) the effective amount of vitamin D in the unit dosage is about 50 mcg.

### Claim 4 (depends on 1)

The composition according to claim 1, wherein the vitamin D is in the form of D3 cholecalciferol.

### Claim 5 (depends on 1)

The composition according to claim 1, wherein the unit dosage is a capsule.

### Claim 6 (depends on 1)

The composition according to claim 1, wherein the composition is a nutraceutical composition.

### Claim 7 (depends on 1)

A method of administering a composition comprising
administering to a subject an effective amount of the composition of claim 1.

### Claim 8 (depends on 7)

The method according to claim 7, wherein administration of the composition to said subject improves sleep quality in the subject.

### Claim 9 (depends on 7)

The method according to claim 7, wherein administration of the composition to said subject improves energy quality in the subject.

### Claim 10 (depends on 7)

The method according to claim 7, wherein administration of the composition to said subject improves mood quality in the subject.

### Claim 11 (depends on 7)

The method according to claim 7, wherein administration of the composition to said subject alleviates pain in the subject.

### Claim 12 (depends on 7)

The method according to claim 7, administration of the composition to said subject improves memory quality in the subject.