# US 12,005,094 B2 · Inhibitor of inflammatory conditions

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- Number: US 12,005,094 B2
- Document ID: US12005094B2
- Status: Granted
- Kind: B2
- Application number: 17/192,133
- Filed: 2021-03-04
- Published: 2021-07-15
- Granted: 2024-06-11
- Earliest claimed: 2009-07-18
- Applicants: Compton Developments Ltd.
- Inventors: Emma Jane Blain; Victor Collin Duance; Ahmed Yasine Ali; Ifor Delme Bowen
- Web page: https://patentgrep.com/patent/US12005094B2

## CPC

- A61K 31/015: carbocyclic
- A61K 36/324: Boswellia, e.g. frankincense
- A61K 31/045: Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K 31/56: Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61K 2236/33: involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention relates to Boswellia frereana and particularly an extract of same for treating a range of inflammatory disorder or conditions selected from the group comprising: psoriasis, demyelinating neurological disorders including multiple sclerosis, all forms of muscular dystrophy especially Duchenne muscular dystrophy, sepsis, sepsis syndrome, osteoporosis, ischemic injury, graft vs. host disease, reperfusion injury, asthma, diabetes, cancer, myelogenous and other leukemias, psoriasis and cachexia, Alzheimer's Disease, acetylcholinesterase mediated disorders, retinal disorders, neurological, retinal, and muscular disorders.

## Claims

### Claim 1

A method of treating a disorder or condition selected from the group consisting of: psoriasis, demyelinating neurological disorders including multiple sclerosis, all forms of muscular dystrophy especially Duchenne muscular dystrophy, sepsis, sepsis syndrome, osteoporosis, ischemic injury, graft vs. host disease, reperfusion injury, asthma, diabetes, cancer, myelogenous and other leukemias, cachexia, Alzheimer's Disease, acetylcholinesterase mediated disorders, retinal disorders, neurological disorders, muscular disorders, and a combination thereof in a patient in need thereof, comprising administering to said patient an effective amount of an alcohol extract of Boswellia frereana, wherein said extract comprises epi-lupeol or a salt thereof, and wherein the extract is devoid of boswellic acids.

### Claim 2 (depends on 1)

The method of claim 1, wherein said extract comprises one or more of the following: β-amyrin, α-amyrin, α-phellandrene dimers, α-thujene, and α-phellandrene, and isomers or salts thereof.

### Claim 3 (depends on 1)

The method of claim 1, wherein said extract comprises one or more of the following: β-amyrin, α-phellandrene dimers, and isomers or salts thereof.

### Claim 4 (depends on 1)

The method of claim 1, wherein said extract is a methanol extract.

### Claim 5 (depends on 1)

The method of claim 1, wherein said extract is an ethanol extract.

### Claim 6 (depends on 1)

The method of claim 1, wherein the muscular dystrophy is Duchenne muscular dystrophy.

### Claim 7

A method of treating a disorder or condition selected from the group consisting of: psoriasis, demyelinating neurological disorders including multiple sclerosis, all forms of muscular dystrophy, sepsis, sepsis syndrome, osteoporosis, ischemic injury, graft vs. host disease, reperfusion injury, asthma, diabetes, cancer, myelogenous and other leukemias, cachexia, Alzheimer's Disease, acetylcholinesterase mediated disorders, retinal disorders, neurological disorders, muscular disorders, and a combination thereof in a patient in need thereof, comprising administering to said patient:
a. an effective amount of an alcohol extract of Boswellia frereana, wherein said extract comprises epi-lupeol or a salt thereof, and wherein the extract is devoid of boswellic acids;
b. a composition comprising an effective amount of an alcohol extract of Boswellia frereana, wherein said extract comprises epi-lupeol or a salt thereof, and wherein the extract is devoid of boswellic acids; or
c. a combination therapeutic comprising:
i.) an effective amount of an alcohol extract of Boswellia frereana, wherein said extract comprises epi-lupeol or a salt thereof, and wherein the extract is devoid of boswellic acids; and
ii.) an additional therapeutic.

### Claim 8 (depends on 7)

The method of claim 7, wherein said extract comprises one or more of the following: β-amyrin, α-amyrin, α-phellandrene dimers, α-thujene, and α-phellandrene, and isomers or salts thereof.

### Claim 9 (depends on 7)

The method of claim 7, wherein said extract comprises one or more of the following: β-amyrin, α-phellandrene dimers, and isomers or salts thereof.

### Claim 10 (depends on 7)

The method of claim 7, wherein said extract is a methanol extract.

### Claim 11 (depends on 7)

The method of claim 7, wherein said extract is an ethanol extract.

### Claim 12 (depends on 7)

The method of claim 7, wherein the muscular dystrophy is Duchenne muscular dystrophy.