# US 12,005,076 B2 · Zinc phosphate complex

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- Number: US 12,005,076 B2
- Document ID: US12005076B2
- Status: Granted
- Kind: B2
- Application number: 15/538,330
- Filed: 2014-12-26
- Published: 2017-12-07
- Granted: 2024-06-11
- Earliest claimed: 2014-12-26
- Assignees: Colgate-Palmolive Company
- Applicants: Colgate-Palmolive Company
- Inventors: Baohua Qiao; Long Pan; Gregory Szewczyk; Ravi Subramanyam
- Web page: https://patentgrep.com/patent/US12005076B2

## CPC

- A61K 33/42: Phosphorus; Compounds thereof
- A61K 6/20: Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
- A61K 6/74: comprising phosphorus-containing compounds
- A61K 8/24: Phosphorous; Compounds thereof
- A61K 8/27: Zinc; Compounds thereof
- A61K 9/0063: {Periodont}
- A61K 33/30: Zinc; Compounds thereof
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61Q 15/00: Anti-perspirants or body deodorants (deodorisation of air A61L9/00)
- C01B 25/37: Phosphates of heavy metals
- A61K 2800/262: Transparent; Translucent
- A61K 2800/58: Metal complex; Coordination compounds
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C01B: NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; {METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C}

## Abstract

A soluble zinc polyphosphate complex made by combining ingredients which include an inorganic zinc salt and a plurality of long chain polyphosphates having 6 or more phosphate polymer units, the relative amount of inorganic zinc salt and long chain polyphosphates providing a phosphorus to zinc mole ratio of at least 6:1. Further provided is a method of making this soluble zinc polyphosphate.

## Claims

### Claim 1

A soluble zinc polyphosphate complex in solution, wherein the complex is obtainable by combining ingredients consisting of zinc chloride and sodium hexametaphosphate in an aqueous solvent;
wherein the zinc polyphosphate complex in solution consists of zinc and a polyphosphate chain, wherein the phosphorus to zinc mole ratio of the zinc polyphosphate complex is 20:1; and
wherein upon contact with proteins in saliva in an oral cavity, the soluble zinc polyphosphate complex forms a precipitate which occludes dentinal tubules.

### Claim 2 (depends on 1)

The complex of claim 1, wherein the zinc polyphosphate complex has a property of becoming insoluble at a pH ranging from 5.5 to 6.5.

### Claim 3 (depends on 1)

The complex of claim 1, wherein the zinc polyphosphate complex is insoluble at a pH below 5.5 in the presence of salivary proteins.

### Claim 4 (depends on 1)

The complex of claim 1, wherein the zinc polyphosphate complex has an average of 1 zinc atom.