# US 12,005,038 B2 · Methods suitable for disrupting a biofilm, and/or killing bacteria contained in a biofilm

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- Number: US 12,005,038 B2
- Document ID: US12005038B2
- Status: Granted
- Kind: B2
- Application number: 17/400,733
- Filed: 2021-08-12
- Published: 2022-02-17
- Granted: 2024-06-11
- Earliest claimed: 2020-08-13
- Assignees: Johnson & Johnson Consumer Inc.
- Applicants: Johnson & Johnson Consumer Inc.
- Inventors: Aliaksandr Zhuk; Anthony Geonnotti; Dara Miller; Jennifer Li; Nikoleta Batchvarova; Nicole Comito
- Web page: https://patentgrep.com/patent/US12005038B2

## CPC

- A61K 8/365: Hydroxycarboxylic acids; Ketocarboxylic acids
- A61K 31/192: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid {(cannabinoids A61K31/658)}
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/60: Sugars; Derivatives thereof
- A61K 8/8152: {Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers}
- A61K 8/8158: {Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers}
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60)
- A61K 31/191: having two or more hydroxy groups, e.g. gluconic acid
- A61K 31/366: having six-membered rings, e.g. delta-lactones
- A61K 31/7004: Monosaccharides having only carbon, hydrogen and oxygen atoms
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/32: Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone}
- A61K 47/34: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence)
- A61P 17/10: Anti-acne agents
- A61P 31/04: Antibacterial agents
- A61Q 19/00: Preparations for care of the skin
- A61K 2300/00: Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Provided are methods and compositions suitable for treating acne, disrupting a biofilm, and/or killing bacteria contained in a biofilm. Certain methods comprise applying to a surface having a biofilm a composition comprising a first alpha hydroxy acid, a second alpha hydroxy acid, and a polyhydroxy acid.

## Claims

### Claim 1

A method of disrupting a biofilm or killing bacteria contained in a biofilm, applying to a surface having a biofilm a composition comprising:
a. about 0.1 wt. % to about 7.5 wt. % glycolic acid;
b. about 0.1 wt. % to about 5 wt. % gluconolactone;
c. about 0.1 wt. % to about 5 wt. % mandelic acid
d. a glycol;
e. a salt-tolerant thickening polymer,
wherein the total amount of glycolic acid, gluconolactone and mandelic acid is less than about 15 wt. % of the total composition,
wherein the composition has a pH of about 3 to about 5 and
wherein the surface is a surface on skin.

### Claim 2 (depends on 1)

The method of claim 1, wherein the skin has acne.

### Claim 3 (depends on 1)

The method of claim 1, wherein the biofilm contains Cutibacterium acnes bacteria.

### Claim 4 (depends on 1)

The method of claim 1, wherein the total amount of acid in the composition is less than about 15 wt. % of the total composition.

### Claim 5 (depends on 1)

The method of claim 1, wherein the composition further comprises a glycol selected from the group consisting of glycerin, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, polyethylene glycol, polypropylene glycol, diethylene glycol, triethylene glycol, caprylyl glycol, glycerol, butanediol and hexanetriol, and copolymers and combinations thereof.

### Claim 6 (depends on 1)

The method of claim 1, wherein the composition is substantially free of lactic acid.

### Claim 7 (depends on 1)

The method of claim 1, wherein the composition is substantially free of salicylic acid.

### Claim 8 (depends on 1)

The method of claim 1, wherein the salt-tolerant thickening polymer is selected from the group consisting of polyacrylate crosspolymer-6, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer and combinations thereof.