# US 12,005,027 B2 · System with improved seal between a liquid container and a manifold

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- Number: US 12,005,027 B2
- Document ID: US12005027B2
- Status: Granted
- Kind: B2
- Application number: 17/755,894
- Filed: 2020-11-10
- Published: 2022-11-10
- Granted: 2024-06-11
- Earliest claimed: 2019-11-12
- Assignees: Siemens Healthcare Diagnostics Inc.
- Applicants: Siemens Healthcare Diagnostics Inc.
- Inventors: Heiko Kalbfell; Joachim Bernhard
- Web page: https://patentgrep.com/patent/US12005027B2

## CPC

- A61J 1/1418: {Threaded type}
- G01N 15/0806: {Details, e.g. sample holders, mounting samples for testing}
- G01N 35/10: Devices for transferring samples {or any liquids} to, in, or from, the analysis apparatus, e.g. suction devices, injection devices {(G01N35/0099 takes precedence)}
- B01L 3/523: {with means for closing or opening}
- B01L 2200/026: Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L 2200/0689: Sealing
- B01L 2400/0487: fluid pressure, pneumatics
- G01N 2035/0403: {Sample carriers with closing or sealing means}
- G01N 2035/0429: {Sample carriers adapted for special purposes}
- A61J: CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

## Abstract

The invention relates to a system with a seal between a manifold and a liquid container in which a sealing without an elastomer material is used, wherein the sealing properties of the seal are independent of the rotational position of the manifold in relation to the container.

## Claims

### Claim 1

A system comprising:
a liquid container, configured to hold a liquid, comprising an opening, a rim surrounding the opening such that the diameter of the opening decreases towards an interior of the liquid container to form a conically shaped inclined inner peripheral support surface, and a first pressure exposure surface;
a manifold comprising a circumferential sealing protrusion having a conically shaped inclined outer peripheral sealing surface configured to form a seal when directly in contact with the conically shaped inclined inner peripheral support surface of the liquid container without an intervening elastic sealing material, an aspirating tube configured to aspirate liquid from the liquid container, a valve configured to fill the liquid container, and a second pressure exposure surface; and
a pressure generating element, configured to be moved by a user between a closed position and an open position, comprising a circumferential first pressure applying surface and a second circumferential pressure applying surface,
wherein the first pressure applying surface contacts the pressure exposure surface of the container and the second pressure applying surface contacts the second pressure exposure surface of the manifold in the open position, and wherein the first and second pressure applying surfaces apply force to the first and second pressure exposure surfaces in the closed position to press the outer peripheral sealing surface of the manifold onto the inner peripheral support surface of the liquid container, forming a sealed connection between the liquid container and the manifold.

### Claim 2 (depends on 1)

The system according to claim 1, wherein the outer peripheral sealing surface and the inner peripheral support surface are made of an injection molded material, wherein the injection molded materials directly contact one another to provide the sealed connection between the manifold and the liquid container.

### Claim 3 (depends on 1)

The system according to claim 1, wherein the manifold comprises a bottom plate covering the opening in the connected state, the bottom plate extending parallel to a first axis extending perpendicular to a central middle axis passing though the container and a center of the opening, the bottom plate comprises a beveled edge portion with decreasing thickness of the plate in direction of the outer edge of the bottom plate, wherein the beveled edge portion is the second pressure exposure surface.

### Claim 4 (depends on 3)

The system according to claim 3, wherein the pressure generating element comprises an inner circumferential inclined surface facing the beveled edge portion in the connected state, wherein the inner circumferential inclined surface is the second pressure applying surface.

### Claim 5 (depends on 3)

The system according to claim 3, wherein the pressure generating element is a two-part element connected through a hinge portion, wherein in the closed position the pressure generating element encloses the rim.

### Claim 6 (depends on 5)

The system according to claim 5, wherein the pressure generating element is a ring shaped element configured as a clamp ring comprising a first ring section and a second ring section connected at first ends of the ring sections through the hinge portion, wherein each ring section comprises an inner recessed area delimited in the axial direction of the ring shaped element by the first pressure applying surface and the second pressure applying surface, wherein the second ends of the first and second ring sections are connected to each other in the closed position by a locking latch.

### Claim 7 (depends on 6)

The system according to claim 6, wherein when the clamp ring is moved by the user to the closed position the diameter of the clamp ring is decreased and the second pressure applying surface is configured to slide on the beveled edge portion in order to press the outer peripheral sealing surface on the inner peripheral support surface.

### Claim 8 (depends on 6)

The system according to claim 6 wherein an absolute value of a first angle between the first pressure applying surface and a first axis extending perpendicular to a central middle axis passing through a center of the clamp ring corresponds to the absolute value of a second angle between the second pressure applying surface and the first axis.

### Claim 9 (depends on 1)

The system according to claim 1, wherein the liquid container comprises, on an outer surface, a circumferential protrusion with a first surface facing away from the opening, wherein the first surface is the container pressure exposure surface.

### Claim 10 (depends on 5)

The system according to claim 5, wherein the pressure generating element comprises a threaded ring comprising a first ring section and a second ring section connected at first ends of the ring sections through the hinge portion, wherein the second ends of the ring sections contact each other in the closed state and provide a recess for receiving the manifold pressure exposure surface.

### Claim 11 (depends on 10)

The system according to claim 10, wherein the recess comprises the second pressure applying surface, wherein in the closed state the threaded ring comprises a threaded circumferential portion providing the first pressure applying surface.