# US 12,004,914 B2 · Customized three-dimensional scaffold for oral and maxillofacial bone grafting

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- Number: US 12,004,914 B2
- Document ID: US12004914B2
- Status: Granted
- Kind: B2
- Application number: 17/470,286
- Filed: 2021-09-09
- Published: 2023-03-09
- Granted: 2024-06-11
- Earliest claimed: 2021-09-09
- Assignees: Dip Co.
- Applicants: Dip, LLC
- Inventors: Amir Juzbasic
- Web page: https://patentgrep.com/patent/US12004914B2

## CPC

- A61C 8/0006: {Periodontal tissue or bone regeneration (support means for endoprosthetic bone substitute or bone graft implants A61F2/2846)}
- A61C 13/0019: {using three dimensional printing}
- A61C 9/0053: {Optical means or methods, e.g. scanning the teeth by a laser or light beam}
- A61C 13/0004: {Computer-assisted sizing or machining of dental prostheses}
- A61F 2/2846: {Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects (nets or sleeves applied to surface of endoprostheses A61F2/30907; bone plates A61B17/80; bone regeneration in dental surgery A61C8/0006)}
- A61F 2/30942: {for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques}
- A61L 27/047: {Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06}
- A61L 27/58: Materials at least partially resorbable by the body
- G16H 20/40: relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
- G16H 30/40: for processing medical images, e.g. editing
- G16H 50/50: for simulation or modelling of medical disorders
- A61F 2002/2889: {Maxillary, premaxillary or molar implants}
- A61F 2002/30062: {(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive}
- A61F 2002/30948: {using computerized tomography, i.e. CT scans}
- A61F 2002/30952: {using CAD-CAM techniques or NC-techniques}
- A61F 2002/30985: {using three dimensional printing [3DP]}
- A61L 2430/12: for dental implants or prostheses
- A61C: DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE (non-driven toothbrushes A46B; {tongue scrapers A61B17/24;} preparations for dentistry A61K6/00; preparations for cleaning the teeth or mouth A61K8/00, A61Q11/00)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

## Abstract

A customized resorbable three-dimensional scaffold for oral and maxillofacial bone grafting involves merging two sets of three-dimensional information obtained from a patient, the first set includes three-dimensional bone information and the second set includes three-dimensional teeth and tissue information. The merged information is used to generate a three-dimensional shape of the bone to be regenerated, a three-dimensional position of the missing tooth/teeth, and a three-dimensional model of the customized resorbable three-dimensional scaffold for oral and maxillofacial bone grafting. The three-dimensional model is used to generate the customized resorbable three-dimensional scaffold and resorbable connectors for the customized resorbable three-dimensional scaffold.

## Claims

### Claim 1

A method for making a customized and resorbable three-dimensional scaffold for oral and maxillofacial bone grafting, the method comprising:
obtaining two different sets of three-dimensional information obtained from a patient, wherein a first set of the two different sets includes three-dimensional bone information and a second set of the two different sets includes three-dimensional teeth and tissue information;
merging the first and second sets of three-dimensional information to form merged three-dimensional information;
generating, using the merged three-dimensional information, a three-dimensional shape of the bone to be regenerated;
generating, using the merged three-dimensional information and based on esthetic, phonetic, and functional parameters, a three-dimensional position of missing tooth/teeth;
generating, using the merged three-dimensional information, the three-dimensional position of the missing tooth/teeth, and the three-dimensional shape of the bone to be regenerated, a three-dimensional model of the customized resorbable three-dimensional scaffold for oral and maxillofacial bone grafting; and
generating, using the three-dimensional model of the customized three-dimensional scaffold, the customized resorbable three-dimensional scaffold and resorbable connectors for the customized resorbable three-dimensional scaffold.

### Claim 2 (depends on 1)

The method of claim 1, wherein the first set of information is obtained using a computerized tomography scanner.

### Claim 3 (depends on 1)

The method of claim 1, wherein the second set of information is obtained using a surface scanner.

### Claim 4 (depends on 1)

The method of claim 1, wherein the customized resorbable three-dimensional scaffold and the resorbable connectors are generated using computer numerical control machine.

### Claim 5 (depends on 1)

The method of claim 1, wherein the customized resorbable three-dimensional scaffold and the resorbable connectors are generated using a three-dimensional printer.

### Claim 6 (depends on 1)

The method of claim 1, wherein the customized resorbable three-dimensional scaffold and the resorbable connectors comprise magnesium.

### Claim 7 (depends on 1)

The method of claim 1, wherein the customized resorbable three-dimensional scaffold and the resorbable connectors consist essentially of magnesium.

### Claim 8 (depends on 1)

The method of claim 1, wherein the first and second sets of three-dimensional information are merged using a computer-aided design program.

### Claim 9

A system for making a customized and resorbable three-dimensional scaffold for oral and maxillofacial bone grafting, the system comprising:
a computer comprising a non-transitory memory and a processor coupled to the non-transitory memory, wherein the processor is configured to
obtain two different sets of three-dimensional information obtained from a patient, wherein a first set of the two different sets includes three-dimensional bone information and a second set of the two different sets includes three-dimensional teeth and tissue information;
merge the first and second sets of three-dimensional information to form merged three-dimensional information;
generate, using the merged three-dimensional information, a three-dimensional shape of the bone to be regenerated;
generate, using the merged three-dimensional information and based on esthetic, phonetic, and functional parameters, a three-dimensional position of missing tooth/teeth;
generate, using the merged three-dimensional information, the three-dimensional position of the missing tooth/teeth, and the three-dimensional shape of the bone to be regenerated, a three-dimensional model of the customized resorbable three-dimensional scaffold for oral and maxillofacial bone grafting; and
a computer numerical control machine or a three-dimensional printer that generates, using the three-dimensional model of the customized three-dimensional scaffold, the customized resorbable three-dimensional scaffold and resorbable connectors for the customized resorbable three-dimensional scaffold.

### Claim 10 (depends on 9)

The system of claim 9, further comprising:
a computerized tomography scanner that generates the first set of information is obtained.

### Claim 11 (depends on 9)

The system of claim 9, further comprising:
a surface scanner that generates the second set of information.

### Claim 12 (depends on 9)

The system of claim 9, wherein the customized resorbable three-dimensional scaffold and the resorbable connectors comprise magnesium.

### Claim 13 (depends on 9)

The system of claim 9, wherein the customized resorbable three-dimensional scaffold and the resorbable connectors consist essentially of magnesium.

### Claim 14 (depends on 9)

The system of claim 9, wherein the processor executes a computer-aided design program to merge the first and second sets of three-dimensional information.

### Claim 15

A non-transitory computer readable medium storing a computer program, which when executed by a processor, causes the processor to:
obtain two different sets of three-dimensional information obtained from a patient, wherein a first set of the two different sets includes three-dimensional bone information and a second set of the two different sets includes three-dimensional teeth and tissue information;
merge the first and second sets of three-dimensional information to form merged three-dimensional information;
generate, using the merged three-dimensional information, a three-dimensional shape of the bone to be regenerated;
generate, using the merged three-dimensional information and based on esthetic, phonetic, and functional parameters, a three-dimensional position of missing tooth/teeth;
generate, using the merged three-dimensional information, the three-dimensional position of the missing tooth/teeth, and the three-dimensional shape of the bone to be regenerated, a three-dimensional model of the customized resorbable three-dimensional scaffold for oral and maxillofacial bone grafting; and
output the three-dimensional model of the customized three-dimensional scaffold to a computer numerical control machine or a three-dimensional printer, wherein the computer numerical control machine or the three-dimensional printer generates, using the three-dimensional model of the customized three-dimensional scaffold, the customized resorbable three-dimensional scaffold and resorbable connectors for the customized resorbable three-dimensional scaffold.

### Claim 16 (depends on 15)

The non-transitory computer readable medium of claim 15, wherein the processor obtains the first set of information from a computerized tomography scanner.

### Claim 17 (depends on 15)

The non-transitory computer readable medium of claim 15, wherein the processor obtains the second set of information from a surface scanner.

### Claim 18 (depends on 15)

The non-transitory computer readable medium of claim 15, wherein the customized resorbable three-dimensional scaffold and the resorbable connectors comprise magnesium.

### Claim 19 (depends on 15)

The non-transitory computer readable medium of claim 15, wherein the customized resorbable three-dimensional scaffold and the resorbable connectors consist essentially of magnesium.

### Claim 20 (depends on 15)

The non-transitory computer readable medium of claim 15, wherein the processor uses a computer-aided design program to merge the first and second sets of three-dimensional information.
