# US 12,004,911 B2 · Biopsy site marker for limited migration

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- Number: US 12,004,911 B2
- Document ID: US12004911B2
- Status: Granted
- Kind: B2
- Application number: 17/528,666
- Filed: 2021-11-17
- Published: 2022-03-10
- Granted: 2024-06-11
- Earliest claimed: 2019-05-30
- Assignees: Devicor Medical Products, Inc.
- Applicants: Devicor Medical Products, Inc.
- Inventors: Elijah Kreider; Peter Shadix; Emmanuel V. Tanghal; Jordan Rebellino; Andrew Small; Ramon Alberto Ramos; Taylor Vohland; Jack A Randall; David C. McBreen; LeRonda Perry; Edward A. Rhad; Jessica P. Leimbach; Sarah Payne; Anne E. Storer; Andrew T. Robinson; John Kevin Bruce; Rachel Yoon Choung
- Web page: https://patentgrep.com/patent/US12004911B2

## CPC

- A61B 90/39: {Markers, e.g. radio-opaque or breast lesions markers}
- A61B 10/02: Instruments for taking cell samples or for biopsy {(A61B10/0038 and A61B10/0045 take precedence; needle locating or guiding means A61B17/3403; samplers for enzymology or microbiology C12M1/26; sampling or preparing biological specimens G01N33/48)}
- A61B 2017/00004: {(bio)absorbable, (bio)resorbable or resorptive}
- A61B 2017/00526: {Methods of manufacturing}
- A61B 2017/00898: {expandable upon contact with fluid}
- A61B 2017/00938: {hydrophobic}
- A61B 2017/00942: {hydrophilic}
- A61B 2090/3908: {Soft tissue, e.g. breast tissue}
- A61B 2090/3925: {ultrasonic}
- A61B 2090/3954: {magnetic, e.g. NMR or MRI}
- A61B 2090/3966: {Radiopaque markers visible in an X-ray image}
- A61B 2090/3987: {Applicators for implanting markers}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A biopsy site marker includes a carrier and a marker element. The marker element is disposed within the carrier. The carrier including a first marker material and a second marker material. The first marker material and the second marker material are each configured to expand in the presence of moisture. The first marker material is configured to expand at a rapid rate relative to the second marker material in the presence of moisture.

## Claims

### Claim 1

A biopsy site marker, comprising:
a carrier; and
a marker element disposed within the carrier, the carrier including a first marker material and a second marker material, the first marker material and the second marker material being arranged linearly with respect to each other, the first marker material and the second marker material being each configured to expand in the presence of moisture, the first marker material being configured to expand at a rapid rate relative to the second marker material in the presence of moisture, and
the first marker material and the second marker material being joined at one or more interfaces disposed between the first marker material and the second marker material, each interface of the one or more interfaces being configured to locally restrict the rate of expansion of the first marker material proximate the interface,
the marker element being disposed within both the first marker material and the second marker material such that the marker element is configured to couple the first marker material to the second marker material.

### Claim 2 (depends on 1)

The marker of claim 1, the first marker material including a first portion disposed on a proximal end of the second marker material and a second portion disposed on a distal end of the second marker material.

### Claim 3 (depends on 2)

The marker of claim 2, the first portion and the second portion of the first marker material each including one or more notches configured to receive tissue.

### Claim 4 (depends on 3)

The marker of claim 3, the first portion and the second portion of the first marker material being each configured to rapidly expand in the presence of moisture relative to the second marker material to form a dumbbell-shaped profile.

### Claim 5 (depends on 1)

The marker of claim 1, the first marker material and the second marker material being connected in an end-to-end configuration.

### Claim 6 (depends on 5)

The marker of claim 5, the first marker material being configured to expand at a rapid rate relative to the second marker material in the presence of moisture to thereby form a tissue plug.

### Claim 7 (depends on 1)

The marker of claim 1, the first marker material being collagen, the second marker material being hydrogel.

### Claim 8

A biopsy site marker, comprising:
a carrier, the carrier including a first marker material and a second marker material arranged linearly along a longitudinal axis, the first marker material and the second marker material being each configured to expand in the presence of moisture; and
a marker element disposed within the first marker material and the second maker material such that the marker element is configured to couple the first marker material to the second marker material, the first marker material being configured to expand at a rapid rate relative to the second marker material in the presence of moisture, and
the first marker material and the second marker material being joined at one or more interfaces disposed between the first marker material and the second marker material, each interface of the one or more interfaces being configured to contain expansion of the first marker material relative to the second marker material such that a portion of the first marker material proximate to the second marker material expands at a relatively slow rate relative to another portion of the first marker material.