# US 12,004,747 B2 · Tissue-joining member, and use thereof

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- Number: US 12,004,747 B2
- Document ID: US12004747B2
- Status: Granted
- Kind: B2
- Application number: 16/977,350
- Filed: 2019-02-26
- Published: 2021-04-15
- Granted: 2024-06-11
- Earliest claimed: 2018-03-02
- Assignees: Ikeda, Tetsuo
- Applicants: Tetsuo Ikeda
- Inventors: Tetsuo Ikeda; Shun Sasaki; Eiji Oki; Shinichiro Okihara
- Web page: https://patentgrep.com/patent/US12004747B2

## CPC

- A61B 17/085: {with adhesive layer}
- A61L 24/102: {Collagen}
- A61L 24/001: {Use of materials characterised by their function or physical properties}
- A61L 24/0015: {Medicaments; Biocides}
- A61L 31/044: {Collagen}
- A61L 31/14: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
- A61B 18/203: {applying laser energy to the outside of the body}
- A61B 2018/00017: {with gas}
- A61B 2018/00047: {using Peltier effect}
- A61B 2018/00452: {Skin}
- A61B 2018/00642: {with feedback, i.e. closed loop control}
- A61B 2018/00678: {upper}
- A61B 2018/00708: {switching the power on or off}
- A61B 2018/00791: {Temperature}
- A61L 2300/442: Colorants, dyes
- A61N 5/0616: {Skin treatment other than tanning}
- A61N 5/0625: {Warming the body, e.g. hyperthermia treatment}
- A61N 5/067: using laser light
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

This tissue-joining member comprises non-crosslinked fibrous collagen. A laminate body comprises: a support; a joining member that is layered on one surface of the support; and a first adhesive layer that is layered on said one surface of the support in a region on which the joining member is not layered. The method for using the joining member or the laminate body comprises: a heating step in which the joining member or the laminate body is heated to less than 60° C. and greater than body temperature after having being layered on the tissue; and a cooling step in which the heated joining member or laminate body is cooled to body temperature or lower. A treatment system comprises a heating unit and the joining member or the laminate body.

## Claims

### Claim 1

A laminate body, comprising:
a support;
a tissue-joining member comprising a non-crosslinked fibrous collagen, which is layered on one surface of the support; and
a first adhesive layer that is layered on said one surface of the support in a region on which the tissue-joining member is not layered.

### Claim 2 (depends on 1)

The laminate body according to claim 1, wherein the tissue-joining member is film-like, sheet-like, or sponge-like.

### Claim 3 (depends on 1)

The laminate body according to claim 1, wherein the tissue-joining member does not comprise water.

### Claim 4 (depends on 1)

The laminate body according to claim 1, wherein the non-crosslinked fibrous collagen is an atelocollagen.

### Claim 5 (depends on 1)

The laminate body according to claim 1, further comprising a second adhesive layer that is layered between the support and the tissue-joining member.

### Claim 6 (depends on 5)

The laminate body according to claim 5, wherein the support or the second adhesive layer comprises a temperature-sensitive material at least in a part thereof.

### Claim 7 (depends on 1)

A method for using the laminate body according to claim 1, the method comprising:
heating the laminate body layered on a tissue to less than 60° C. and greater than body temperature; and
cooling the laminate body to body temperature or lower.

### Claim 8 (depends on 1)

A treatment system comprising:
the laminate body according to claim 1; and
a heating unit.

### Claim 9 (depends on 8)

The treatment system according to claim 8, further comprising a temperature control unit configured to control the heating unit such that a temperature of the laminate body heated by the heating unit is less than 60° C. and greater than body temperature.

### Claim 10 (depends on 8)

The treatment system according to claim 8, wherein the heating unit is a laser.

### Claim 11

A method comprising:
heating a tissue-joining member layered on a tissue to less than 60° C. and greater than body temperature, the tissue-joining member comprising a non-crosslinked fibrous collagen; and
cooling the heated joining member to body temperature or lower.

### Claim 12

A treatment system comprising:
a tissue-joining member comprising a non-crosslinked fibrous collagen;
a heating unit; and
a temperature control unit configured to control the heating unit such that a temperature of the tissue-joining member heated by the heating unit is less than 60° C. and greater than body temperature.

### Claim 13

A treatment system comprising:
a tissue-joining member comprising a non-crosslinked fibrous collagen; and
a heating unit, wherein the heating unit is a laser.