# US 12,004,729 B2 · Method and system for use in a lung access procedure to aid in preventing pneumothorax

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- Number: US 12,004,729 B2
- Document ID: US12004729B2
- Status: Granted
- Kind: B2
- Application number: 17/537,927
- Filed: 2021-11-30
- Published: 2022-03-24
- Granted: 2024-06-11
- Earliest claimed: 2019-10-18
- Assignees: Bard Peripheral Vascular, Inc.
- Applicants: Bard Peripheral Vascular, Inc.
- Inventors: Jordan Addison; Nicholas Mowrey; Heather Storm
- Web page: https://patentgrep.com/patent/US12004729B2

## CPC

- A61B 17/00491: {Surgical glue applicators}
- A61B 17/0057: {Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect (sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009)}
- A61B 17/3421: {Cannulas}
- A61L 24/043: {Mixtures of macromolecular materials}
- A61L 24/046: {obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds (A61L24/043 takes precedence)}
- A61B 2017/00367: {Details of actuation of instruments, e.g. relations between pushing buttons, or the like, and activation of the tool, working tip, or the like}
- A61B 2017/00495: {for two-component glue}
- A61B 2017/00557: {inflatable (A61B2017/22051 takes precedence)}
- A61B 2017/0065: {the implement being an adhesive}
- A61B 2017/00809: {Lung operations}
- A61B 2017/3419: {Sealing means between cannula and body}
- A61B 2017/3486: {Balloon}
- A61B 2017/3492: {against the outside of the body}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

A method for use in a lung access procedure to aid in preventing pneumothorax includes providing a cannula having a pair of balloons, the pair of balloons including a first balloon longitudinally spaced from a second balloon along the cannula; inserting the cannula along an access opening and through pleural layers of a patient, with the first balloon and the second balloon of the pair of balloons respectively positioned on opposite sides of the pleural layers; inflating the pair of balloons with a first amount of a two-component sealant to compress the pleural layers together; and inflating the pair of balloons with a second amount of the two-component sealant that is sufficient to rupture the pair of balloons so as to comingle a first sealant component and a second sealant component of the two-component sealant at the site of the pleural layers so as to adhere the pleural layers together.

## Claims

### Claim 1

A method for use in a lung access procedure to aid in preventing pneumothorax, comprising:
providing a cannula having a pair of balloons, the pair of balloons including a first balloon longitudinally spaced from a second balloon along the cannula;
inserting the cannula along an access opening and through pleural layers of a patient, with the first balloon and the second balloon of the pair of balloons respectively positioned on opposite sides of the pleural layers;
inflating the pair of balloons with a first amount of a two-component sealant to compress the pleural layers together; and
inflating the pair of balloons with a second amount of the two-component sealant that is sufficient to rupture the pair of balloons so as to comingle a first sealant component and a second sealant component of the two-component sealant at the site of the pleural layers so as to adhere the pleural layers together.

### Claim 2 (depends on 1)

The method of claim 1, further comprising withdrawing the cannula and the pair of ruptured balloons along the access opening to aid in comingling the first sealant component and the second sealant component of the two-component sealant at the pleural layers and in the access opening.

### Claim 3 (depends on 2)

The method of claim 2, wherein the step of withdrawing follows the step of inflating the pair of balloons with the second amount of the two-component sealant to rupture the pair of balloons.

### Claim 4 (depends on 1)

The method of claim 1, wherein the first balloon is inflated with the first sealant component of the two-component sealant at each of the first amount and the second amount, and the second balloon is inflated with the second sealant component of the two-component sealant at each of the first amount and the second amount.

### Claim 5 (depends on 1)

The method of claim 1, wherein the first sealant component comingles with the second sealant component to form a sealant gel.

### Claim 6 (depends on 1)

The method of claim 1, wherein the first sealant component has at least two N-hydroxysuccinimide (NHS) ester groups and the second sealant component has at least two amine groups.

### Claim 7 (depends on 1)

The method of claim 1, wherein the first sealant component is polyethylene glycol (PEG) succinimidyl succinate and the second sealant component is taken from a group consisting of albumin, polyethylenimine (PEI), and a functionalized PEG having at least two amine groups.

### Claim 8 (depends on 1)

The method of claim 1, wherein following the compression of the pleural layers together and prior to rupturing the pair of balloons, the method further comprising accessing lung tissue via a lumen of the cannula.

### Claim 9 (depends on 1)

The method of claim 1, wherein the steps of inflating are performed by the steps of:
connecting a sealant applicator to the cannula; and
actuating an actuator of the sealant applicator to simultaneously supply the first sealant component of the two-component sealant to the first balloon and supply the second sealant component of the two-component sealant to the second balloon.

### Claim 10 (depends on 9)

The method of claim 9, wherein the step of actuating the actuator comprises depressing a plunger handle of a syringe-type applicator.