# US 12,004,512 B1 · N-[(4,6-dimethylpyrimidin-2-yl)carbamothioyl] pyridine-3-carboxamide as an eco-friendly insecticidal agent against Spodoptera littoralis (boisd.)

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- Number: US 12,004,512 B1
- Document ID: US12004512B1
- Status: Granted
- Kind: B1
- Application number: 18/486,910
- Filed: 2023-10-13
- Granted: 2024-06-11
- Earliest claimed: 2023-10-13
- Assignees: King Faisal University
- Applicants: King Faisal University
- Inventors: Mai Mostafa Khalaf Ali; Hany Mohamed Abd El-Lateef Ahmed; Antar Ahmed Abdelhamid Ahmed; Mohamed A. Gad
- Web page: https://patentgrep.com/patent/US12004512B1

## CPC

- A01N 47/28: Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< (isoureas, isothioureas A01N47/42)
- A01P 7/04: Insecticides
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01P: BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS

## Abstract

Synthesis of a compound N-[(4,6-dimethylpyrimidin-2-yl)carbamothioyl]pyridine-3-carboxamide and its use as an insecticidal agent.

## Claims

### Claim 1

An insecticidally acceptable composition comprising an insecticidally effective amount of a N-[(4,6-dimethylpyrimidin-2-yl)carbamothioyl]pyridine-3-carboxamide compound having the formula I:
and an insecticidally acceptable carrier.

### Claim 2 (depends on 1)

A method of killing insects comprising applying to said insects or to a target site of insect infestation an insecticidally effective amount of the insecticidally active composition of claim 1 wherein the insecticidally acceptable composition targets an insect that belongs to a species of Spodoptera littoralis.

### Claim 3 (depends on 2)

The method of killing insects of claim 2, wherein the insecticidally acceptable composition has an LC50 of about 142.1 ppm against the species Spodoptera littoralis after 72 hours of treatment.

### Claim 4 (depends on 2)

The method of killing insects of claim 2, wherein the insecticidally acceptable composition has an LC50 of about 142.1 ppm against 2nd instars of larvae of the species Spodoptera littoralis after 72 hours of treatment.

### Claim 5 (depends on 2)

The method of killing insects of claim 2, wherein the insecticidally acceptable composition has an LC90 of about 320.6 ppm against the species Spodoptera littoralis after 72 hours of treatment.

### Claim 6 (depends on 2)

The method of killing insects of claim 2, wherein the insecticidally acceptable composition has an LC50 of about 320.6 ppm against 4th instars of larvae of the species Spodoptera littoralis after 72 hours of treatment.

### Claim 7 (depends on 2)

The method of killing insects of claim 2, wherein the insecticidally acceptable composition a is applied to castor leaves.

### Claim 8 (depends on 2)

The method of killing insects of claim 2, wherein about 12.5 to about 200 ppm of the insecticidally acceptable composition is applied to the insects or to the target site.

### Claim 9 (depends on 1)

A method of repelling insects comprising applying to a target site of insect infestation an insect repelling effective amount of the insecticidally active composition of claim 1 wherein the insects belong to a species of Spodoptera littoralis.

### Claim 10 (depends on 1)

A method of controlling an insect pest comprising applying to a target site of insect infestation an insect controlling effective amount of the insecticidally active composition of claim 1 wherein the insect pest belongs to a species of Spodoptera littoralis.