# US 12,000,916 B2 · Simultaneous emission-transmission tomography in an MRI hardware framework > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,000,916 B2 - Document ID: US12000916B2 - Status: Granted - Kind: B2 - Application number: 17/279,400 - Filed: 2019-03-13 - Published: 2021-12-16 - Granted: 2024-06-04 - Earliest claimed: 2018-03-14 - Assignees: Rensselaer Polytechnic Institute - Applicants: Rensselaer Polytechnic Institute - Inventors: Ge Wang; Lars Arne Gjesteby; Wenxiang Cong - Web page: https://patentgrep.com/patent/US12000916B2 ## CPC - G01R 33/481: {MR combined with positron emission tomography [PET] or single photon emission computed tomography [SPECT]} - A61B 6/037: {Emission tomography} - A61B 6/4258: {for detecting non x-ray radiation, e.g. gamma radiation (A61B6/037 takes precedence)} - A61B 6/4417: {related to combined acquisition of different diagnostic modalities} - A61B 6/5235: {combining images from the same or different ionising radiation imaging techniques, e.g. PET and CT} - G01R 33/0385: {in relation with magnetic force measurements (magnetic force microscopes G01Q60/50)} - G01R 33/38: Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field - G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A simultaneous emission-transmission tomography in an MRI hardware framework is described. A method of multimodality imaging includes reconstructing, by a simultaneous emission transmission (SET) circuitry, a concentration image based, at least in part, on a plurality of selected γ-rays; and reconstructing, by the SET circuitry, an attenuation image based, at least in part, on the plurality of selected γ-rays. The plurality of selected γ-rays is emitted by a polarized radio tracer included in a test object. The selected γ-rays are selected based, at least in part, on a radio frequency (RF) pulse and based, at least in part, on a gradient magnetic field. ## Claims ### Claim 1 A method of multimodality imaging, the method comprising: reconstructing, by a simultaneous emission transmission (SET) circuitry, a concentration image based, at least in part, on a plurality of selected γ-rays; and reconstructing, by the SET circuitry, an attenuation image based, at least in part, on the plurality of selected γ-rays, the plurality of selected γ-rays emitted by a polarized radio tracer included in a test object, the selected γ-rays selected based, at least in part, on a radio frequency (RF) pulse and based, at least in part, on a gradient magnetic field. ### Claim 2 (depends on 1) The method of claim 1, further comprising: providing, by a main magnetic field source device, a uniform main magnetic field to the test object; adjusting, by a gradient magnetic field device, the main magnetic field to yield the gradient magnetic field; and providing, by RF source circuitry, the RF pulse to the test object. ### Claim 3 (depends on 2) The method of claim 2, wherein the adjusting is configured to select γ-rays emitted from a location with pixel resolution. ### Claim 4 (depends on 2) The method of claim 2, wherein the adjusting is configured to select γ-rays emitted from a location with a fraction of a pixel resolution. ### Claim 5 (depends on 2) The method of claim 2, wherein the main magnetic field source device is stationary. ### Claim 6 (depends on 2) The method of claim 2, wherein the main magnetic field source device is configured to rotate about the test object. ### Claim 7 (depends on 1) The method of claim 1, wherein the reconstructed images correspond to the entire test object. ### Claim 8 (depends on 1) The method of claim 1, wherein the reconstructed images correspond to a region of interest included in the test object. ### Claim 9 (depends on 8) The method of claim 8, wherein the reconstructing is based, at least in part, on a known tracer concentration at a reference point pixel. ### Claim 10 (depends on 1) An SET device configured for performing the method according to claim 1, the SET device comprising a main magnetic field source, a gradient magnetic field source, and an RF source. ### Claim 11 (depends on 1) A non-transitory computer readable storage device having stored thereon instructions that when executed by one or more processors result in the following operations comprising the method according to claim 1. ### Claim 12 A simultaneous emission transmission (SET) system comprising: a SET circuitry configured to reconstruct a concentration image based, at least in part, on a plurality of selected γ-rays and to reconstruct an attenuation image based, at least in part, on the plurality of selected γ-rays, the plurality of selected γ-rays emitted by a polarized radio tracer included in a test object, the selected γ-rays selected based, at least in part, on a radio frequency (RF) pulse and based, at least in part, on a gradient magnetic field. ### Claim 13 (depends on 12) The system of claim 12, further comprising: a main magnetic field source device configured to provide a uniform main magnetic field to the test object; a gradient magnetic field device configured to adjust the main magnetic field to yield the gradient magnetic field; and an RF source circuitry configured to provide the RF pulse to the test object. ### Claim 14 (depends on 13) The system of claim 13, wherein the adjusting is configured to select g-rays emitted from a location with pixel resolution. ### Claim 15 (depends on 13) The system of claim 13, wherein the adjusting is configured to select g-rays emitted from a location with a fraction of a pixel resolution. ### Claim 16 (depends on 13) The system of claim 13, wherein the main magnetic field source device is stationary. ### Claim 17 (depends on 13) The system of claim 13, wherein the main magnetic field source device is configured to rotate about the test object. ### Claim 18 (depends on 12) The system of claim 12, wherein the reconstructed images correspond to the entire test object. ### Claim 19 (depends on 12) The system of claim 12, wherein the reconstructed images correspond to a region of interest included in the test object. ### Claim 20 (depends on 19) The system of claim 19, wherein the reconstructing is based, at least in part, on a known tracer concentration at a reference point pixel.