# US 12,000,832 B2 · Marker composition for diagnosing or predicting prognosis of lung cancer based on exosome overexpressing GCC2 gene or protein

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- Number: US 12,000,832 B2
- Document ID: US12000832B2
- Status: Granted
- Kind: B2
- Application number: 17/539,030
- Filed: 2021-11-30
- Published: 2022-06-23
- Granted: 2024-06-04
- Earliest claimed: 2017-11-07
- Assignees: Korea University Research and Business Foundation; Korea Advanced Institute of Science and Technology
- Applicants: Korea University Research and Business Foundation; Korea Advanced Institute of Science and Technology
- Inventors: Hyun Koo Kim; Sung Hoi Hong; Yong Park; Yeon Ho Choi; Ji Ho Park; Byeong Hyeon Choi; Hye Sun Jeong
- Web page: https://patentgrep.com/patent/US12000832B2

## CPC

- G01N 33/5752: of the lungs
- C07K 16/3023: {Lung}
- C12Q 1/6886: for cancer (immunoassay for cancer G01N33/575)
- C12Q 2600/106: Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
- C12Q 2600/118: Prognosis of disease development
- C12Q 2600/156: Polymorphic or mutational markers
- C12Q 2600/158: Expression markers
- G01N 2800/52: Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES

## Abstract

According to an embodiment of the present invention, a composition for diagnosing or predicting the prognosis of lung cancer is provided, the composition including a primer, probe, or antibody that specifically binds to a GRIP and coiled-coil domain-containing protein (GCC2) gene or protein in an exosome.

## Claims

### Claim 1

A method for identifying a level of GCC2 expression, the method comprising below steps:
(a) obtaining a blood sample from a suspected lung cancer subject;
(b) separating an exosome from the blood sample; and
(c) measuring an expression level of a GCC2 (GRIP and coiled-coil domain-containing protein) protein in the exosome.

### Claim 2 (depends on 1)

The method of claim 1, wherein the (b) step is performed by using a composition containing an antibody that specifically binds to a GCC2 protein.