# US 12,000,823 B2 · Simultaneous disease detection system method and devices > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,000,823 B2 - Document ID: US12000823B2 - Status: Granted - Kind: B2 - Application number: 17/832,632 - Filed: 2022-06-04 - Published: 2022-11-17 - Granted: 2024-06-04 - Earliest claimed: 2020-07-11 - Applicants: Matthew Hummer; Gregory J. Hummer - Inventors: Matthew Hummer; Gregory J. Hummer - Web page: https://patentgrep.com/patent/US12000823B2 ## CPC - A61B 5/082: {Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath (A61B5/083, A61B5/091 take precedence)} - G01N 33/48792: {Data management, e.g. communication with processing unit (for in vivo diagnostics A61B5/0002; transmission systems for measured values G08C)} - A61B 5/0022: {Monitoring a patient using a global network, e.g. telephone networks, internet} - A61B 5/097: Devices for facilitating collection of breath or for directing breath into or through measuring devices - G01N 33/48714: {for determining substances foreign to the organism, e.g. drugs or heavy metals (drugs by chemical analysis G01N33/94)} - G01N 33/4875: {Details of handling test elements, e.g. dispensing or storage, not specific to a particular test method (test-elements per se B01L, automatic analysers G01N35/00, in-vivo analysis on the human body for medical diagnosis A61B)} - G01N 33/5438: {Electrodes} - G01N 33/569: for microorganisms, e.g. protozoa, bacteria, viruses - G01N 33/56983: {Viruses} - G16H 10/40: for data related to laboratory analysis, e.g. patient specimen analysis - G16H 10/60: for patient-specific data, e.g. for electronic patient records - G16H 40/20: for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms - G16H 40/63: for local operation - G16H 50/20: for computer-aided diagnosis, e.g. based on medical expert systems - G16H 50/80: for detecting, monitoring or modelling epidemics or pandemics, e.g. flu - A61B 5/14507: {specially adapted for measuring characteristics of body fluids other than blood (devices for taking samples of body liquids A61B10/0045)} - A61B 5/14539: {for measuring pH} - A61B 5/1477: non-invasive - A61B 2562/12: Manufacturing methods specially adapted for producing sensors for in-vivo measurements - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract The embodiments disclose a method including providing impedimetric biosensor electrodes and circuits on a substrate, providing at least two different biopolymer materials on the conductive impedimetric biosensors electrodes and circuits, applying a predetermined electrical current to the impedimetric biosensor electrodes for establishing a baseline value, providing at least one biologic sample onto the impedimetric biosensors electrodes for detection of at least one disease microorganism, measuring the electrical current after contact with the at least one biologic sample for changes in the baseline value, recording changes in the electrical current measurements, analyzing the electrical current measurements for identifying predetermined detected disease microorganisms electrical current measurements changes, and determining the concentration of a detected disease microorganism. ## Claims ### Claim 1 A method, comprising: providing conductive impedimetric biosensor electrodes and conductive circuits on a substrate; providing at least two different biopolymer materials on the conductive impedimetric biosensors electrodes and conductive circuits; applying a predetermined impedance/electrical current to the conductive impedimetric biosensor electrodes for establishing a baseline current value; providing at least one biologic sample onto the conductive impedimetric biosensors electrodes for detection of at least one disease microorganism; measuring the electrical field and ionic strength of the at least one biologic sample using an electrical field and ionic strength measuring device to determine the speed of sensing performance; releasing chemical bonding within the at least one biologic sample by using photon energy being directly applied to a graphene layer structure to remove oxygen residuals within; measuring the impedance/electrical current after contact with the at least one biologic sample for changes in the baseline current value; recording changes in the impedance/electrical current measurements; analyzing the recorded changes in the impedance/electrical current measurements for identifying predetermined detected disease microorganisms electrical current measurements changes in the baseline current value; and determining from the microorganisms impedance/electrical current measurements changes to determine the concentration of a detected at least one disease microorganism. ### Claim 2 (depends on 1) The method of claim 1, wherein depositing at least one biologic sample different from another at least one biologic sample includes a liquid biologic sample from a group consisting of amniotic fluid, aqueous humour, bile, blood, blood plasma, breast milk, breathe moisture, cerebrospinal fluid, cells, cerumen, clots, chyle, coagulates, exudates, gastric juice, lymph, mucus, nasopharyngeal, pericardial fluid, peritoneal fluid, pleural fluid, pus, saliva, sebum, serous fluid, semen, sputum, serum, synovial fluid, sweat, tears, urine and vomit, plasma, lymph, cells, tissue, clots, coagulants and amniotic fluid samples. ### Claim 3 (depends on 1) The method of claim 1, wherein at least two different genetic materials of the at least one disease microorganism genetic material are selected from a group consisting of disease microorganisms, deficiency disease microorganism, heredity disease microorganism, physiological disease microorganism, biological pathogens, including viruses, bacteria, fungi, and parasites including bacterial pathogens and viruses including SARS-CoV-2, other viruses, Methicillin-resistant Staphylococcus aureus (MSRA), Legionnaires and other disease microorganisms. ### Claim 4 (depends on 1) The method of claim 1, further comprising reporting any detected disease microorganism testing results to a user smart phone having a simultaneous disease app for displaying the testing results. ### Claim 5 (depends on 1) The method of claim 1, further comprising establishing an impedance baseline current value for use in analyzing current measurements after contact with a biologic sample wherein current values above the baseline are a positive result. ### Claim 6 (depends on 1) The method of claim 1, further comprising establishing an impedance baseline current value for use in analyzing current measurements after contact with a biologic sample wherein values below the baseline are a negative result. ### Claim 7 (depends on 1) The method of claim 1, further comprising transmitting recorded impedance/electrical current measurements to algorithms in a cloud for analysis. ### Claim 8 A method, comprising: providing conductive impedimetric biosensor electrodes and conductive circuits on a substrate; providing at least two different biopolymer materials on the conductive impedimetric biosensors electrodes and conductive circuits; applying a predetermined impedance/electrical current to the conductive impedimetric biosensor electrodes for establishing a baseline current value; providing at least one biologic sample onto the conductive impedimetric biosensors electrodes for detection of at least one disease microorganism; raising the temperature of the at least one biologic sample to a specific set point for a set period of time, using an incubation temperature control device; measuring the electrical field and ionic strength of the at least one biologic sample using an electrical field and ionic strength measuring device to determine the speed of sensing performance; releasing chemical bonding within the at least one biologic sample by using photon energy being directly applied to a graphene layer structure to remove oxygen residuals within; measuring the impedance/electrical current after contact with the at least one biologic sample for changes in the baseline current value; recording changes in the impedance/electrical current measurements; analyzing the recorded changes in the impedance/electrical current measurements for identifying predetermined detected disease microorganisms electrical current measurements changes in the baseline current value; and determining from the microorganisms impedance/electrical current measurements changes to determine the concentration of a detected at least one disease microorganism. ### Claim 9 (depends on 8) The method of claim 8, further comprising reporting any detected disease microorganism testing results to a user smart phone having a simultaneous disease app for displaying the testing results. ### Claim 10 (depends on 8) The method of claim 8, further comprising transmitting recorded impedance/electrical current measurements to algorithms in a cloud for analysis. ### Claim 11 A method, comprising: providing conductive impedimetric biosensor electrodes and conductive circuits made of materials selected from a group of at least one of gold, silver, copper, nickel, or platinum on a substrate; providing at least two different biopolymer materials on the conductive impedimetric biosensors electrodes and conductive circuits; applying a predetermined impedance/electrical current to the conductive impedimetric biosensor electrodes for establishing a baseline current value; providing at least one biologic sample onto the conductive impedimetric biosensors electrodes for detection of at least one disease microorganism; measuring salt concentration of the at least one biologic sample using a saline detector; measuring the electrical field and ionic strength of the at least one biologic sample using an electrical field and ionic strength measuring device to determine the speed of sensing performance; releasing chemical bonding within the at least one biologic sample by using photon energy being directly applied to a graphene layer structure to remove oxygen residuals within; measuring the impedance/electrical current after contact with the at least one biologic sample for changes in the baseline current value; recording changes in the impedance/electrical current measurements; analyzing the recorded changes in the impedance/electrical current measurements for identifying predetermined detected disease microorganisms electrical current measurements changes in the baseline current value; and detecting any number and multiple types of viruses and bacterial pathogens using impedimetric detection of analytical targets; and determining from the microorganisms impedance/electrical current measurements changes to determine the concentration of a detected at least one disease microorganism. ### Claim 12 (depends on 11) The method of claim 11, wherein measuring the electrical field and ionic strength of the at least one biologic sample that affects the speed of sensing performance. ### Claim 13 (depends on 11) The method of claim 11, wherein the conductive impedimetric biosensor electrodes and conductive circuits are made of materials selected from a group of at least one of gold, silver, copper, nickel, or platinum. ### Claim 14 (depends on 11) The method of claim 11, wherein measuring the electrical field and ionic strength and salt concentration of the of the at least one biologic sample are factors calculated using a digital processor to anticipate optimal sensing performance time and adjusts a time of an operation of the electrical power and current level to complete an electrical current and impedance measurement processing.