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US 11,999,982 B2Granted
Method for the fermentative production of guanidinoacetic acid
AssigneeEvonik Operations GmbH
InventorsFrank Schneider, Frank Jankowitsch
Life of this patent
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Abstract
A microorganism is transformed to be capable of producing guanidinoacetic acid (GAA). A method can be used for the fermentative production of GAA using such a microorganism. A corresponding method can be used for the fermentative production of creatine.
Claims28
A microorganism, comprising:
- at least one gene coding for a protein having a function of a L-arginine:glycine amidinotransferase, and wherein an activity of a protein having a function of a malate synthase is decreased compared to the respective activity in a corresponding wildtype microorganism,
- wherein the protein having the function of the L-arginine:glycine amidinotransferase comprises an amino acid sequence which is at least 80% identity to the amino acid sequence according to SEQ ID NO:
- 11.
A microorganism, comprising:
- at least one gene coding for a protein having a function of a L-arginine:glycine amidinotransferase, and wherein an activity of a protein having a function of a malate synthase is decreased compared to the respective activity in a corresponding wildtype microorganism,
- comprising at least one gene encoding a protein having an enzymic activity of a glyoxylate aminotransferase is overexpressed, and
- wherein the protein having the enzymic activity of the glyoxylate aminotransferase comprises an amino acid sequence which is at least 80% identity to the amino acid sequence according to SEQ ID NO:2, according to SEQ ID NO:
- 5, or according to SEQ ID NO:
- 8.
2 more elements
Dependencies are inferred from the claim text.