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US 11,999,853 B2Granted
Engineered skin equivalent, method of manufacture thereof and products derived therefrom
AssigneesVitroLabs Inc, King's College London
InventorsIngvar Helgason, Dusko Ilic
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Abstract
Disclosed herein are synthetic leathers, artificial epidermal layers, artificial dermal layers, layered structures, products produced therefrom and methods of producing the same.
Claims12
A method of forming a tanned synthetic leather, wherein the method comprises:
- culturing a fibroblast on a scaffold comprising a cellulose, a modified cellulose, or a combination thereof;
- and
- tanning a collagenous extracellular matrix comprising collagen secreted by the fibroblast to generate the tanned synthetic leather.
A composition comprising a cell layer comprising a fibroblast in contact with a scaffold;
- wherein the scaffold comprises a cellulose, a modified cellulose, or a combination thereof;
- and
- wherein the cell layer comprises a collagen.
Dependencies are inferred from the claim text.