Broad-spectrum polypeptide against enterovirus and application thereof
AssigneesWuhan Institute of Virology, Chinese Academy of Sciences, Fudan University
InventorsXi Zhou, Lu Lu, Yuan Fang, Shibo Jiang, Zezhong Liu, Chengfeng Qin, Yang Qiu, Jingfang Mu
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Abstract
Provided are a series of polypeptides with antiviral activity. The present invention provides a new strategy for preventing and controlling Enterovirus such as EV71, CVA16, CVA6, CVB3, and CVB5 viruses and provides a new theoretical basis for accelerating the research and development of a polypeptide small molecule drug against Enterovirus such as EV71, CVA16, CVA6, CVB3, and CVB5 viruses.
Claims9
A polypeptide capable of inhibiting the activity of enterovirus protein 3A, wherein the polypeptide consists of a sequence selected from the group consisting of SEQ ID NOs:
- 2 to 14.
An inhibitor of enterovirus, wherein the inhibitor is polypeptide P2 with the amino acid sequence shown in SEQ ID NO:
- 2.
A variant of an inhibitor of enterovirus, wherein the variant is 3A-TAT-EP with the amino acid sequence as shown in SEQ ID NO:
- 3, 3A-EP-DRI with the amino acid sequence as shown in SEQ ID NO:
- 4, or 3A-EP-PEG4-PA with the amino acid sequence as shown in SEQ ID NO:
- 5.
Dependencies are inferred from the claim text.