Anti-factor IX padua antibodies
AssigneeTakeda Pharmaceutical Company Limited
InventorsDirk Voelkel, Robert Pachlinger, Hanspeter Rottensteiner, Alfred Weber, Andrea Engelmaier
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Abstract
Provided herein are anti-Factor IX Padua binding constructs, e.g., antibodies and antigen-binding fragments thereof. Related polypeptides, conjugates and kits are also provided. The inventions may be used in methods of detecting Factor IX Padua in a sample.
Claims20
An anti-Factor IX Padua binding construct comprising two or more antigen-binding fragments each comprising a heavy chain variable region (VH) and a light chain variable region (VL), wherein at least one of the antigen-binding fragments comprises the HCDR1, HCDR2, and HCDR3 amino acid sequences of SSYAIS (SEQ ID NO:
- 6), GIVPAFGTANYAQKFQG (SEQ ID NO:
- 7), and SWGVISFAY (SEQ ID NO:
- 8);
- and the LCDR1, LCDR2, and LCDR3 amino acid sequences of RASQDISSYLN (SEQ ID NO:
- 9), AASNLQS (SEQ ID NO:
- 10), and MQYDSLPFTF (SEQ ID NO:
- 11).
Dependencies are inferred from the claim text.