# US 11,999,753 B2 · Tetrahydropyridopyrimidine pan-KRas inhibitors

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- Number: US 11,999,753 B2
- Document ID: US11999753B2
- Status: Granted
- Kind: B2
- Application number: 17/553,224
- Filed: 2021-12-16
- Published: 2022-06-23
- Granted: 2024-06-04
- Earliest claimed: 2020-12-16
- Assignees: Mirati Therapeutics, Inc.
- Applicants: Mirati Therapeutics, Inc.
- Inventors: Xiaolun Wang; Anthony Ivetac; Svitlana Kulyk; John David Lawson; Matthew Arnold Marx; Christopher Ronald Smith
- Web page: https://patentgrep.com/patent/US11999753B2

## CPC

- C07D 519/00: Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- A61P 35/00: Antineoplastic agents
- C07D 471/04: Ortho-condensed systems
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to compounds that inhibit at least one of KRas wild type, KRas G12A, KRas G12C, KRas G12D, KRas G12R, KRas G12S, KRas G12V, KRas G13D and KRas Q61H, pharmaceutical compositions comprising the compounds and methods of use therefor.

## Claims

### Claim 1

A compound selected from:
and a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

The compound of claim 1, wherein the compound is
or a pharmaceutically acceptable salt thereof.

### Claim 3 (depends on 1)

The compound of claim 1, wherein the compound is
or a pharmaceutically acceptable salt thereof.

### Claim 4 (depends on 1)

The compound of claim 1, wherein the compound is
or a pharmaceutically acceptable salt thereof.

### Claim 5 (depends on 1, 3, 4)

A pharmaceutical composition comprising a therapeutically effective amount of a compound of any one of claim 1, 3, 4, or 2 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.