# US 11,999,711 B1 · 2-(benzo[b]thiophen-3-yl)-1-butyl-4,5-diphenyl-1H-imidazole as an anti-inflammatory and anti-microbial compound

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- Number: US 11,999,711 B1
- Document ID: US11999711B1
- Status: Granted
- Kind: B1
- Application number: 18/415,162
- Filed: 2024-01-17
- Granted: 2024-06-04
- Earliest claimed: 2023-09-05
- Assignees: King Faisal University
- Applicants: King Faisal University
- Inventors: Mai Mostafa Khalaf Ali; Hany Mohamed Abd El-Lateef Ahmed; Antar Ahmed Abdelhamid Ahmed; Adel A. Marzouk
- Web page: https://patentgrep.com/patent/US11999711B1

## CPC

- C07D 401/04: directly linked by a ring-member-to-ring-member bond
- A61P 31/04: Antibacterial agents
- A61P 31/10: Antimycotics
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A compound 2-(Benzo[b]thiophen-3-yl)-1-butyl-4.5-diphenyl-1H-imidazole compound, its synthesis, and its use as an anti-microbial and anti-inflammatory agent.

## Claims

### Claim 1

A method of treating a microbial infection in a patient comprising administering to a patient in need thereof a therapeutically effective amount of a 2-(Benzo[b]thiophen-3-yl)-1-butyl-4,5-diphenyl-1H-imidazole compound having the formula I:

### Claim 2 (depends on 1)

The method of treating the microbial infection of claim 1, wherein the microbial infection is caused by one or more bacteria or fungi.

### Claim 3 (depends on 2)

The method of treating the microbial infection of claim 2, wherein the microbial infection is caused by one or more Gram-negative bacterial strains selected from the group consisting of Escherichia coli and Pseudomonas aeruginosa; one or more Gram-positive bacterial strains that is Staphylococcus aureus; Candida albicans; or any combination thereof.

### Claim 4 (depends on 2)

The method of treating the microbial infection of claim 2, wherein the microbial infection is caused by Candida albicans.

### Claim 5 (depends on 2)

The method of treating the microbial infection of claim 2, wherein the microbial infection is caused by Escherichia coli or Pseudomonas aeruginosa.

### Claim 6 (depends on 2)

The method of treating the microbial infection of claim 2, wherein the microbial infection is caused by one or more Gram-positive bacterial strains Staphylococcus aureus.