# US 11,999,699 B2 · Substituted pyrazole amides > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,999,699 B2 - Document ID: US11999699B2 - Status: Granted - Kind: B2 - Application number: 17/840,712 - Filed: 2022-06-15 - Published: 2023-01-26 - Granted: 2024-06-04 - Earliest claimed: 2021-06-15 - Assignees: GrüNenthal GmbH - Applicants: Gruenenthal GmbH - Inventors: Sebastian Krueger; Sebastian Peil; Clemens Dialer; Marcel Muelbaier; Markus Wagener; Ingo Konetzki; Nikolay Sitnikov; Jo Alen; Martin Pettersson - Web page: https://patentgrep.com/patent/US11999699B2 ## CPC - C07D 231/14: with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms - A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] - C07D 231/20: One oxygen atom attached in position 3 or 5 - C07D 401/12: linked by a chain containing hetero atoms as chain links - C07D 403/12: linked by a chain containing hetero atoms as chain links - C07D 405/06: linked by a carbon chain containing only aliphatic carbon atoms - C07D 405/14: containing three or more hetero rings - C07D 413/12: linked by a chain containing hetero atoms as chain links - C07D 493/08: Bridged systems - C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract The present invention relates to compounds according to general formula (I) which act as inhibitors of NaV1.8 and can be used in the treatment of pain. ## Claims ### Claim 1 A compound according to general formula (I) wherein L represents CH2, CH(CH3) or CH(CH2CH3); R1 represents C3-10-cycloalkyl, or 4 to 10-membered heterocycloalkyl, R2 represents H or C1-6-alkyl; X represents phenyl, or 5 to 10-membered heteroaryl; R3 represents S(O)2—C1-6-alkyl, S(O)2—(C3-6-cycloalkyl), S(O)2-(4 to 6-membered heterocycloalkyl), S(O)2-phenyl, S(O)2-(5 or 6-membered heteroaryl), S(O)—NH2, S(O)—N(H)(C1-6-alkyl), S(O)—N(C1-6-alkyl)2, S(O)2—NH2, S(O)2—N(H)(C1-6-alkyl), S(O)2—N(H)(C3-6-cycloalkyl), S(O)2—N(C1-6-alkyl)2, C(O)—NH2, C(O)—N(H)(C1-6-alkyl), C(O)—N(H)(C3-6-cycloalkyl), C(O)—N(C1-6-alkyl)2, C(O)—N(C1-6-alkyl)(C3-6-cycloalkyl), OCF3, OCF2H, CN, OH, O—C3-6-cycloalkyl, O-(4 to 6-membered heterocycloalkyl), S(O)—C1-6-alkyl, S(O)—(C3-6-cycloalkyl), S(O)-(4 to 6-membered heterocycloalkyl), S(O)-phenyl, or S(O)-(5 or 6-membered heteroaryl); R4 and R5 independently from one another represent H, F, Cl, Br, CN, CHF2, CH2F, CF3, C1-6-alkyl, C3-10-cycloalkyl, C1-6-alkylene-C3-10-cycloalkyl, 4 to 10-membered heterocycloalkyl, C1-6-alkylene-(4 to 10-membered heterocycloalkyl), NH2, N(H)(C1-6-alkyl), N(C1-6-alkyl)2, O—C1-6-alkyl, O—C3-10-cycloalkyl, O—C1-6-alkylene-C3-10-cycloalkyl, O-(4 to 6-membered heterocycloalkyl), or O—C1-6-alkylene-(4 to 6-membered heterocycloalkyl), provided that at least one of R4 and R5 does not represent H; wherein C1-6-alkyl and C1-6-alkylene in each case independently from one another is linear or branched; wherein C1-6-alkyl, C1-6-alkylene, C3-10-cycloalkyl, C3-6-cycloalkyl, 4 to 10-membered heterocycloalkyl and 4 to 6-membered heterocycloalkyl in each case independently from one another are unsubstituted or mono- or polysubstituted with F; and/or are unsubstituted or monosubstituted with one substituent selected from the group consisting of Cl, CN, C1-6-alkyl, C1-6-alkylene-OH, C1-6-alkylene-OCH3, CF3, CF2H, CFH2, C(O)—C1-6-alkyl, OH, ═O, OCF3, OCF2H, OCFH2, O—C1-6-alkyl, C1-4-alkylene-O—C1-4-alkylene-O—CH3, and C0-4-alkylene-O—(C1-4-alkylene-O)1-4—CH3; wherein phenyl, 5 to 10-membered heteroaryl and 5 or 6-membered heteroaryl in each case independently from one another are unsubstituted or mono- or polysubstituted with one or more substituents selected from the group consisting of F, Cl, Br, CN, C1-6-alkyl, C3-6-cycloalkyl, CF3, CF2H, CFH2, C1-6-alkylene-CF3, C1-6-alkylene-CF2H, C1-6-alkylene-CFH2, C1-6-alkylene-OH, C1-6-alkylene-OCH3, C(O)—C1-6-alkyl, OCF3, OCF2H, OCFH2, and O—C1-6-alkyl; in the form of the free compound or a physiologically acceptable salt thereof. ### Claim 2 (depends on 1) The compound according to claim 1, wherein R3 represents S(O)2—C1-6-alkyl, S(O)2—(C3-6-cycloalkyl), S(O)2-(4 to 6-membered heterocycloalkyl), S(O)2-phenyl, S(O)2-(5 or 6-membered heteroaryl), S(O)—NH2, S(O)—N(H)(C1-6-alkyl), S(O)—N(C1-6-alkyl)2, C(O)—NH2, C(O)—N(H)(C1-6-alkyl), C(O)—N(H)(C3-6-cycloalkyl), C(O)—N(C1-6-alkyl)2, C(O)—N(C1-6-alkyl)(C3-6-cycloalkyl), OCF3, OCF2H, CN, OH, O—C3-6-cycloalkyl, O-(4 to 6-membered heterocycloalkyl), S(O)—C1-6-alkyl, S(O)—(C3-6-cycloalkyl), S(O)-(4 to 6-membered heterocycloalkyl), S(O)-phenyl, or S(O)-(5 or 6-membered heteroaryl). ### Claim 3 (depends on 1) The compound according claim 1, wherein R4 and R5 independently from one another represent H, F, Cl, Br, CN, CHF2, CH2F, CF3, C1-6-alkyl, C1-6-alkylene-C3-10-cycloalkyl, C1-6-alkylene-(4 to 10-membered heterocycloalkyl), NH2, N(H)(C1-6-alkyl), N(C1-6-alkyl)2, O—C1-6-alkyl, O—C3-10-cycloalkyl, O—C1-6-alkylene-C3-10-cycloalkyl, O-(4 to 6-membered heterocycloalkyl), or O—C1-6-alkylene-(4 to 6-membered heterocycloalkyl). ### Claim 4 (depends on 1) The compound according to claim 1, wherein R2 represents H. ### Claim 5 (depends on 1) The compound according to claim 1, wherein R4 and R5 independently from one another represent H, F, Cl, CN, CHF2, CH2F, CF3, CH2CHF2, CH2CH2F, CH2CF3, CF2CH3, CHFCH3, CF2CF3, CHFCF3, CH(CHF2)(CH3), CH(CH2F)(CH3), CH(CF3)(CH3), CH3, CH2CH3, CH(CH3)2, cyclopropyl, CH2-cyclopropyl, CF2-cyclopropyl, O—CHF2, O—CH2F, O—CF3, O—CH2CHF2, O—CH2CH2F, O—CH2CF3, O—CF2CH3, O—CHFCH3, O—CF2CF3, O—CHFCF3, O—CH3, O—CH2CH3, O—CH(CH3)2, O-cyclopropyl, or O—CH2-cyclopropyl, provided that at least one of R4 and R5 does not represent H. ### Claim 6 (depends on 1) The compound according to claim 1, wherein R1 represents C3-10-cycloalkyl selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl; wherein the C3-10-cycloalkyl is unsubstituted or mono- or polysubstituted with F; and/or is unsubstituted or monosubstituted with one substituent selected from the group consisting of Cl, CN, CH3, CF3, CHF2, CH2FOH, OCH3, OCF3, OCF2H, OCFH2, and CH2—O—CH2CH2—O—CH3; or 4 to 10-membered heterocycloalkyl selected from the group consisting of oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, morpholinyl, thiomorpholinyl, tetrahydrothiopyranyl, tetrahydrothiopyranyl 1,1-dioxide, oxepanyl, piperidinyl, piperidinonyl, azetidinyl, pyrrolidinyl, pyrrolidinonyl, 4-methylpiperazinyl, morpholinonyl, dioxanyl, piperazinyl, and tetrahydropyrrolyl; wherein the 4 to 10-membered heterocycloalkyl is unsubstituted or mono- or polysubstituted with F; and/or is unsubstituted or monosubstituted with one substituent selected from the group consisting of Cl, CN, CH3, CF3, CHF2, CH2F, OH, OCH3, OCF3, OCF2H, and OCFH2. ### Claim 7 (depends on 6) The compound according to claim 6, wherein R1 represents cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, tetrahydrofuranyl, or tetrahydropyranyl; wherein said cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, tetrahydrofuranyl, or tetrahydropyranyl is unsubstituted or mono- or polysubstituted with F; and/or is unsubstituted or monosubstituted with CH3 or CF3. ### Claim 8 (depends on 1) The compound according to claim 1, wherein X represents phenyl, wherein phenyl is unsubstituted or mono- or polysubstituted with one or more substituents selected from the group consisting of F, Cl, Br, CN, CH3, CF3, CHF2, CH2F, OH, OCH3, OCF3, OCF2H, and OCFH2; or 5 to 10-membered heteroaryl selected from the group consisting of pyridyl, pyrazolyl, pyrrolo[2,3-b]pyridyl, pyridonyl, thienyl, thiazolyl, 2,3-dihydrobenzo[d]isothiazolyl 1,1-dioxide, isoindolinonyl, pyrimidinyl, pyrazinyl, pyridazinyl, isoxazolyl, triazolyl, oxazolyl, oxadiazolyl, indazolyl, pyrazolopyridyl, pyrrolyl, imidazolyl, isothiazolyl, furanyl, and thiadiazolyl; wherein said 5 to 10-membered heteroaryl is unsubstituted or mono- or polysubstituted with one or more substituents selected from the group consisting of F, Cl, Br, CN, CH3, CF3, CHF2, CH2F, OH, OCH3, OCF3, OCF2H, and OCFH2. ### Claim 9 (depends on 8) The compound according to claim 8, wherein X represents phenyl, pyridyl, pyrazolyl, or pyrrolo[2,3-b]pyridyl; wherein said phenyl, pyridyl, pyrazolyl, or pyrrolo[2,3-b]pyridyl is unsubstituted or mono- or polysubstituted with F. ### Claim 10 (depends on 1) The compound according to claim 1, wherein R3 represents S(O)2—NH2, S(O)2—CH3, S(O)2-(cyclopropyl), S(O)2-(oxetanyl), S(O)2-phenyl, S(O)2-(pyridyl), S(O)—NH2, S(O)—N(H)(CH3), S(O)—N(CH3)2, C(O)—NH2, C(O)—N(H)(CH3), C(O)—N(H)(cyclopropyl), C(O)—N(CH3)2, C(O)—N(CH3)(cyclopropyl), OCF3, OCF2H, CN, OH, O-cyclopropyl, O-(oxetanyl), S(O)—CH3, S(O)-(cyclopropyl), S(O)-(oxetanyl), S(O)-phenyl, or S(O)-(pyridyl). ### Claim 11 (depends on 10) The compound according to claim 10, wherein R3 represents S(O)2—CH3, C(O)NH2, OH, S(O)—CH3, or S(O)2—NH2. ### Claim 12 A compound selected from the group consisting of: SC-01 2-(cyclohexylmethyl)-N-(3-methylsulfonylphenyl)-5-(trifluoromethyl)pyrazole-3- carboxamide SC-02 2-[ (4,4-difluorocyclohexyl)methyl] -N-(3-methylsulfonylphenyl)-5-(trifluoromethyl)pyrazole- 3-carboxamide; SC-03 2-(cyclopentylmethyl)-N-(3-methylsulfonylphenyl)-5-(trifluoromethyl)pyrazole-3- carboxamide; SC-04 N-(3-methylsulfonylphenyl)-2-(oxan-4-ylmethyl)-5-(trifluoromethyl)pyrazole-3-carboxamide; SC-05 2-[ (4,4-difluorocyclohexyl)methyl] -N-(3-methylsulfonylphenyl)-4-(trifluoromethyl)pyrazole- 3-carboxamide; SC-06 2-(cyclohexylmethyl)-4,5-dimethyl-N-(3-methylsulfonylphenyl)pyrazole-3-carboxamide; SC-07 1-(cyclohexylmethyl)-3,4-dimethyl-N-(2-oxo-1,2-dihydropyridin-4-yl)-1H-pyrazole-5- carboxamide; SC-08 2-(cyclohexylmethyl)-4-fluoro-N-(3-methylsulfonylphenyl)pyrazole-3-carboxamide; SC-09 1-(cyclohexylmethyl)-3-(difluoromethyl)-N-(3-(methylsulfonyl)phenyl)-1H-pyrazole-5- carboxamide; SC-10 4-cyano-2-(cyclohexylmethyl)-N-(3-methylsulfonylphenyl)pyrazole-3-carboxamide; SC-11 2-(cyclohexylmethyl)-5-methyl-N-(3-methylsulfonylphenyl)pyrazole-3-carboxamide; SC-12 2-(cyclohexylmethyl)-5-cyclopropyl-N-(3-methylsulfonylphenyl)pyrazole-3-carboxamide; SC-13 2-[ (4,4-difluorocyclohexyl)methyl] -N-(4-fluoro-3-methylsulfonylphenyl)-4- (trifluoromethyl)pyrazole-3-carboxamide; SC-14 2-[ (4,4-difluorocyclohexyl)methyl] -N-(2-methylsulfonylpyridin-4-yl)-4- (trifluoromethyl)pyrazole-3-carboxamide; SC-15 2-[ (4,4-difluorocyclohexyl)methyl] -N-(5-methylsulfonylpyridin-3-yl)-4- (trifluoromethyl)pyrazole-3-carboxamide; SC-16 2-[ (4,4-difluorocyclohexyl)methyl] -N-(2-fluoro-3-methylsulfonylphenyl)-4- (trifluoromethyl)pyrazole-3-carboxamide; SC-17 2-(cyclohexylmethyl)-5-methoxy-N-(3-methylsulfonylphenyl)pyrazole-3-carboxamide; SC-18 2-(cyclohexylmethyl)-N-(3-methylsulfonylphenyl)-4-propan-2-ylpyrazole-3-carboxamide; SC-19 2-(cyclohexylmethyl)-4-cyclopropyl-N-(3-methylsulfonylphenyl)pyrazole-3-carboxamide; SC-21 N-(4-carbamoyl-3-fluorophenyl)-1-[ (4,4-difluorocyclohexyl)methyl] -4-(trifluoromethyl)-1H- pyrazole-5-carboxamide; SC-22 2-[ (4,4-difluorocyclohexyl)methyl] -N-(2-fluoro-5-methylsulfonylphenyl)-4- (trifluoromethyl)pyrazole-3-carboxamide; SC-23 2-[ (3,3-difluorocyclohexyl)methyl] -N-(3-methylsulfonylphenyl)-4-(trifluoromethyl)pyrazole- 3-carboxamide; SC-24 2-(cyclobutylmethyl)-N-(3-methylsulfonylphenyl)-4-(trifluoromethyl)pyrazole-3-carboxamide; SC-25 2-(cyclopentylmethyl)-N-(3-methylsulfonylphenyl)-4-(trifluoromethyl)pyrazole-3- carboxamide; SC-26 2-(cyclohexylmethyl)-N-(3-methylsulfonylphenyl)-4-(trifluoromethyl)pyrazole-3- carboxamide; SC-27 2-(cycloheptylmethyl)-N-(3-methylsulfonylphenyl)-4-(trifluoromethyl)pyrazole-3- carboxamide; SC-28 N-(3-methylsulfonylphenyl)-2-(oxan-4-ylmethyl)-4-(trifluoromethyl)pyrazole-3-carboxamide; SC-29 2-(1-cyclohexylethyl)-N-(3-methylsulfonylphenyl)-4-(trifluoromethyl)pyrazole-3- carboxamide; SC-30 1-(cyclohexylmethyl)-N-(2-oxo-l,2-dihydropyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5- carboxamide; SC-31 2-(cycloheptylmethyl)-N-(2-hydroxypyridin-4-yl)-4-(trifluoromethyl)pyrazole-3-carboxamide; SC-32 2-(1-cyclohexylethyl)-N-(2-hydroxypyridin-4-yl)-4-(trifluoromethyl)pyrazole-3-carboxamide; SC-33 2-(cyclohexylmethyl)-N-(3-sulfamoylphenyl)-4-(trifluoromethyl)pyrazole-3-carboxamide; SC-35 N-(3-carbamoyl-4-fluorophenyl)-1-(cyclohexylmethyl)-4-(trifluoromethyl)-1H-pyrazole-5- carboxamide; SC-36 2-(cyclohexylmethyl)-N-(1-methylsulfonylpyrazol-4-yl)-4-(trifluoromethyl)pyrazole-3- carboxamide; SC-37 2-(cyclohexylmethyl)-4-methyl-N-(3-methylsulfonylphenyl)pyrazole-3-carboxamide; SC-38 5-cyano-2-(cyclohexylmethyl)-N-(3-methylsulfonylphenyl)pyrazole-3-carboxamide; SC-39 N-(3-carbamoyl-4-fluorophenyl)-2-[ (4,4-difluorocyclohexyl)methyl] -4- (trifluoromethyl)pyrazole-3-carboxamide; SC-41 N-(3-carbamoylphenyl)-2-[ (4,4-difluorocyclohexyl)methyl] -4-(trifluoromethyl)pyrazole-3- carboxamide; SC-42 2-[ (4,4-difluorocyclohexyl)methyl] -N-(3-fluoro-5-methylsulfonylphenyl)-4- (trifluoromethyl)pyrazole-3-carboxamide; SC-43 2-[ (4,4-difluorocyclohexyl)methyl] -N-(3-sulfamoylphenyl)-4-(trifluoromethyl)pyrazole-3- carboxamide; SC-44 2-[ (4,4-difluorocyclohexyl)methyl] -4,5-dimethyl-N-(3-methylsulfonylphenyl)pyrazole-3- carboxamide; SC-45 3,4-dimethyl-N-(3-sulfamoylphenyl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-pyrazole-5- carboxamide; SC-46 2-(cyclohexylmethyl)-5-methyl-N-(3-methylsulfonylphenyl)-4-(trifluoromethyl)pyrazole-3- carboxamide; SC-47 N-(3-carbamoyl-4-fluorophenyl)-2-[ (4,4-difluorocyclohexyl)methyl] -5-methyl-4- (trifluoromethyl)pyrazole-3-carboxamide; SC-48 2-[ (4,4-difluorocyclohexyl)methyl] -N-(4-fluoro-3-sulfamoylphenyl)-4,5-dimethylpyrazole-3- carboxamide; SC-49 2-[ (4,4-difluorocyclohexyl)methyl] -N-(4-fluoro-3-sulfamoylphenyl)-4- (trifluoromethyl)pyrazole-3-carboxamide; SC-50 4-[ [ 2-[ (4,4-difluorocyclohexyl)methyl] -4-(trifluoromethyl)pyrazole-3- carbonyl] amino] pyridine-2-carboxamide; SC-51 2-[ (4,4-difluorocyclohexyl)methyl] -4,5-dimethyl-N-(3-sulfamoylphenyl)pyrazole-3- carboxamide; SC-52 N-(3-(methylsulfonyl)phenyl)-1-((tetrahydro-2H-pyran-3-yl)methyl)-4-(trifluoromethyl)-1H- pyrazole-5-carboxamide; SC-53 2-(cyclohexylmethyl)-N-(1-methylsulfonylpyrrolo[ 2,3-b] pyridin-3-yl)-4- (trifluoromethyl)pyrazole-3-carboxamide; SC-54 5-methyl-N-(3-methylsulfonylphenyl)-2-(oxan-3-ylmethyl)-4-(trifluoromethyl)pyrazole-3- carboxamide; SC-55 5-methyl-N-(3-methylsulfonylphenyl)-2-(oxan-2-ylmethyl)-4-(trifluoromethyl)pyrazole-3- carboxamide; SC-56 5-methyl-N-(3-methylsulfonylphenyl)-2-(oxolan-2-ylmethyl)-4-(trifluoromethyl)pyrazole-3- carboxamide; SC-57 2-[ (4,4-difluorocyclohexyl)methyl] -5-methyl-N-(3-sulfamoylphenyl)-4- (trifluoromethyl)pyrazole-3-carboxamide; SC-60 2-[ (3,3-difluorocyclopentyl)methyl] -N-(3-sulfamoylphenyl)-4-(trifluoromethyl)pyrazole-3- carboxamide; SC-61 N-(3-carbamoylphenyl)-2-[ (4,4-difluorocyclohexyl)methyl] -5-methyl-4- (trifluoromethyl)pyrazole-3-carboxamide; SC-62 2-[ (4,4-difluorocyclohexyl)methyl] -5-methyl-N-(3-methylsulfonylphenyl)-4- (trifluoromethyl)pyrazole-3-carboxamide; SC-63 3-methyl-N-(3-(methylsulfonyl)phenyl)-1-((tetrahydrofuran-3-yl)methyl)-4-(trifluoromethyl)- lH-pyrazole-5-carboxamide; SC-64 2-(cyclohexylmethyl)-N-(2-hydroxypyridin-4-yl)-5-methyl-4-(trifluoromethyl)pyrazole-3- carboxamide; SC-65 N-(3-carbamoyl-4-fluorophenyl)-2-[ (4,4-difluorocyclohexyl)methyl] -4,5-dimethylpyrazole-3- carboxamide; SC-66 N-(2-hydroxypyridin-4-yl)-5-methyl-2-(oxan-4-ylmethyl)-4-(trifluoromethyl)pyrazole-3- carboxamide; SC-67 N-(2-hydroxypyridin-4-yl)-3-methyl-1-((tetrahydro-2H-pyran-3-yl)methyl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-68 N-(2-hydroxypyridin-4-yl)-3-methyl-1-((tetrahydro-2H-pyran-2-yl)methyl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-69 2-[ (4,4-difluorocyclohexyl)methyl] -N-(2-sulfamoylpyridin-4-yl)-4-(trifluoromethyl)pyrazole- 3-carboxamide; SC-73 N-(3-carbamoyl-4-fluorophenyl)-2-[ (3,3-difluorocyclopentyl)methyl] -4- (trifluoromethyl)pyrazole-3-carboxamide; SC-77 4-[ [ 2-[ (4,4-difluorocyclohexyl)methyl] -4,5-dimethylpyrazole-3-carbonyl] amino] pyridine-2- carboxamide; SC-78 (1-((3,3-difluorocyclopentyl)methyl)-N-(3-sulfamoylphenyl)-4-(trifluoromethyl)-1H- pyrazole-5-carboxamide; SC-80 1-((3,3-difluorocyclopentyl)methyl)-N-(2-sulfamoylpyridin-4-yl)-4-(trifluoromethyl)-1H- pyrazole-5-carboxamide; SC-82 1-((3,3-difluorocyclopentyl)methyl)-N-(2-(methylsulfonyl)pyridin-4-yl)-4-(trifluoromethyl)- 1H-pyrazole-5-carboxamide; SC-84 4-(1-((4,4-difluorocyclohexyl)methyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-85 1-((4,4-difluorocyclohexyl)methyl)-3-methyl-N-(2-(methylsulfonyl)pyridin-4-yl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-86 4-(1-((4,4-difluorocyclohexyl)methyl)-4-(difluoromethyl)-3-methyl-1H-pyrazole-5- carboxamido)picolinamide; SC-87 1-((4,4-difluorocyclohexyl)methyl)-4-(difluoromethyl)-3-methyl-N-(2- (methylsulfonyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide; SC-88 N-(3-carbamoyl-4-fluorophenyl)-1-((4,4-difluorocyclohexyl)methyl)-4-(difluoromethyl)-3- methyl-1H-pyrazole-5-carboxamide; SC-89 1-((4,4-difluorocyclohexyl)methyl)-4-(difluoromethyl)-3-methyl-N-(3-sulfamoylphenyl)-1H- pyrazole-5-carboxamide; SC-90 4-(3-chloro-1-((4,4-difluorocyclohexyl)methyl)-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-91 3-chloro-1-((4,4-difluorocyclohexyl)methyl)-N-(2-(methylsulfonyl)pyridin-4-yl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-92 N-(3-carbamoyl-4-fluorophenyl)-3-chloro-1-((4,4-difluorocyclohexyl)methyl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-93 3-chloro-1-((4,4-difluorocyclohexyl)methyl)-N-(3-sulfamoylphenyl)-4-(trifluoromethyl)-1H- pyrazole-5-carboxamide; SC-94 4-(1-((4,4-difluorocyclohexyl)methyl)-4-methyl-3-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-95 1-((4,4-difluorocyclohexyl)methyl)-4-methyl-N-(2-(methylsulfonyl)pyridin-4-yl)-3- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-96 N-(3-carbamoyl-4-fluorophenyl)-1-((4,4-difluorocyclohexyl)methyl)-4-methyl-3- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-97 1-((4,4-difluorocyclohexyl)methyl)-4-methyl-N-(3-sulfamoylphenyl)-3-(trifluoromethyl)-1H- pyrazole-5-carboxamide; SC-98 4-(1-((4,4-difluorocyclohexyl)methyl)-3-(difluoromethyl)-4-methyl-1H-pyrazole-5- carboxamido)picolinamide; SC-99 1-((4,4-difluorocyclohexyl)methyl)-3-(difluoromethyl)-4-methyl-N-(2- (methylsulfonyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide; SC-100 N-(3-carbamoyl-4-fluorophenyl)-1-((4,4-difluorocyclohexyl)methyl)-3-(difluoromethyl)-4- methyl-lH-pyrazole-5-carboxamide; SC-101 1-((4,4-difluorocyclohexyl)methyl)-3-(difluoromethyl)-4-methyl-N-(3-sulfamoylphenyl)-1H- pyrazole-5-carboxamide; SC-102 4-(4-chloro-1-((4,4-difluorocyclohexyl)methyl)-3-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-103 4-chloro-1-((4,4-difluorocyclohexyl)methyl)-N-(2-(methylsulfonyl)pyridin-4-yl)-3- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-104 N-(3-carbamoyl-4-fluorophenyl)-4-chloro-1-((4,4-difluorocyclohexyl)methyl)-3- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-105 4-chloro-1-((4,4-difluorocyclohexyl)methyl)-N-(3-sulfamoylphenyl)-3-(trifluoromethyl)-1H- pyrazole-5-carboxamide; SC-106 1-((3,3-difluorocyclopentyl)methyl)-3-methyl-N-(3-sulfamoylphenyl)-4-(trifluoromethyl)-1H- pyrazole-5-carboxamide; SC-108 1-((3,3-difluorocyclopentyl)methyl)-3-methyl-N-(2-(methylsulfonyl)pyridin-4-yl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-110 4-(1-((3,3-difluorocyclopentyl)methyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-112 N-(3-carbamoyl-4-fluorophenyl)-1-((3,3-difluorocyclopentyl)methyl)-3-methyl-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-114 1-((3,3-difluorocyclopentyl)methyl)-4-methyl-N-(3-sulfamoylphenyl)-3-(trifluoromethyl)-1H- pyrazole-5-carboxamide; SC-116 1-((3,3-difluorocyclopentyl)methyl)-4-methyl-N-(2-(methylsulfonyl)pyridin-4-yl)-3- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-118 4-(1-((3,3-difluorocyclopentyl)methyl)-4-methyl-3-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-120 N-(3-carbamoyl-4-fluorophenyl)-1-((3,3-difluorocyclopentyl)methyl)-4-methyl-3- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-122 4-(3-methyl-1-((3,3,4,4-tetrafluorocyclopentyl)methyl)-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-123 3-methyl-N-(2-(methylsulfonyl)pyridin-4-yl)-1-((3,3,4,4-tetrafluorocyclopentyl)methyl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-124 4-(1-((4,4-difluorocyclohexyl)methyl)-3-(difluoromethyl)-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-125 1-((4,4-difluorocyclohexyl)methyl)-3-(difluoromethyl)-N-(2-(methylsulfonyl)pyridin-4-yl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-126 N-(3-carbamoyl-4-fluorophenyl)-1-((4,4-difluorocyclohexyl)methyl)-3-(difluoromethyl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-127 1-((4,4-difluorocyclohexyl)methyl)-3-(difluoromethyl)-N-(3-sulfamoylphenyl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-128 4-(3-cyclopropyl-1-((4,4-difluorocyclohexyl)methyl)-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-129 4-(3-cyclopropyl-1-((3,3-difluorocyclopentyl)methyl)-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-131 4-(3-cyclopropyl-1-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-132 3-cyclopropyl-N-(2-(methylsulfonyl)pyridin-4-yl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-133 4-(3-cyclopropyl-1-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethoxy)-1H-pyrazole-5- carboxamido)picolinamide; SC-134 4-(3-methoxy-1-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-135 4-(3-cyclopropyl-1-((2-methyltetraliydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)-1H- pyrazole-5-carboxamido)picolinamide; SC-138 4-(3-cyclopropyl-1-((5-methyltetraliydrofuran-3-yl)methyl)-4-(trifluoromethyl)-1H-pyrazole- 5-carboxamido)picolinamide; SC-139 4-(3-cyclopropyl-1-((5-methyltetrahydrofuran-2-yl)methyl)-4-(trifluoromethyl)-1H-pyrazole- 5-carboxamido)picolinamide; SC-140 N-(3-carbamoyl-4-fluorophenyl)-3-cyclopropyl-1-((tetrahydro-2H-pyran-2-yl)methyl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-141 N-(3-carbamoyl-4-fluorophenyl)-1-((3,3-difluorocyclobutyl)methyl)-3-(difluoromethyl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-143 4-(3-cyclopropyl-1-((6-methyltetrahydro-2H-pyran-2-yl)methyl)-4-(trifluoromethyl)-1H- pyrazole-5-carboxamido)picolinamide; SC-144 4-(3-cyclopropyl-1-((3,3-difluorocyclobutyl)methyl)-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-145 4-(3-cyclopropyl-1-((tetraliydro-2H-pyran-3-yl)methyl)-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-147 4-(3-cyclopropyl-4-(trifluoromethyl)-1-((2-(trifluoromethyl)tetrahydrofuran-3-yl)methyl)-1H- pyrazole-5-carboxamido)picolinamide; SC-148 4-(3-cyclopropyl-4-(trifluoromethyl)-1-((5-(trifluoromethyl)tetrahydrofuran-3-yl)methyl)-1H- pyrazole-5-carboxamido)picolinamide; SC-149 4-(4-chloro-1-((3,3-difluorocyclopentyl)methyl)-3-(1,1-difluoroethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-150 3-cyclopropyl-N-(2-(methylsulfonyl)pyridin-4-yl)-4-(trifluoromethyl)-1-((2- (trifluoromethyl)tetrahydrofuran-3-yl)methyl)-1H-pyrazole-5-carboxamide; SC-151 3-cyclopropyl-1-((3,3-difluorocyclobutyl)methyl)-N-(2-(methylsulfonyl)pyridin-4-yl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-153 3-cyclopropyl-4-(difluoromethyl)-N-(2-(methylsulfonyl)pyridin-4-yl)-1-((tetrahydro-2H- pyran-4-yl)methyl)-1H-pyrazole-5-carboxamide; SC-154 4-(3-cyclopropyl-1-((2,2-difluorocyclobutyl)methyl)-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-155 4-(1-((3,3-difluorocyclopentyl)methyl)-3-isopropoxy-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-156 4-(1-((3,3-difluorocyclopentyl)methyl)-3-ethoxy-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-157 4-(3-(cyclopropylmethoxy)-1-((3,3-difluorocyclopentyl)methyl)-4-(trifluoromethyl)-1H- pyrazole-5-carboxamido)picolinamide; SC-158 4-(1-((3,3-difluorocyclopentyl)methyl)-3-(difluoromethoxy)-4-(trifluoromethyl)-1H-pyrazole- 5-carboxamido)picolinamide; SC-159 4-(1-(cyclobutylmethyl)-3-cyclopropyl-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-160 4-(4-chloro-1-((3,3-difluorocyclopentyl)methyl)-3-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-161 4-(1-((3,3-difluorocyclobutyl)methyl)-3-(1,1-difluoroethyl)-4-methyl-1H-pyrazole-5- carboxamido)picolinamide; SC-163 4-(1-((4,4-difluorocyclohexyl)methyl)-3-(difluoromethyl)-4-methyl-1H-pyrazole-5- carboxamido)picolinamide; SC-165 1-((3,3-difluorocyclopentyl)methyl)-3-(1,1-difluoroethyl)-4-methyl-N-(2- (methylsulfonyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide; SC-166 3-(1,1-difluoroethyl)-4-methyl-N-(2-(methylsulfonyl)pyridin-4-yl)-1-((3,3,4,4- tetrafluorocyclopentyl)methyl)-1H-pyrazole-5-carboxamide; SC-167 4-(1-((3,3-difluorocyclopentyl)methyl)-3-(1,1-difluoroethyl)-4-methyl-1H-pyrazole-5- carboxamido)picolinamide; SC-168 4-(3-(1,1-difluoroethyl)-4-methyl-1-((3,3,4,4-tetrafluorocyclopentyl)methyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-169 1-((3,3-difluorocyclobutyl)methyl)-3-isopropyl-N-(2-(methylsulfonyl)pyridin-4-yl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-170 4-(1-((3,3-difluorocyclobutyl)methyl)-3-isopropyl-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-171 1-((3,3-difluorocyclobutyl)methyl)-3-ethyl-N-(2-(methylsulfonyl)pyridin-4-yl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-172 4-(1-((3,3-difluorocyclobutyl)methyl)-3-ethyl-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-173 1-((3,3-difluorocyclobutyl)methyl)-N-(2-(methylsulfonyl)pyridin-4-yl)-4-(trifluoromethyl)-3- (1,1,1-trifluoropropan-2-yl)-1H-pyrazole-5-carboxamide; SC-174 4-(1-((3,3-difluorocyclobutyl)methyl)-4-(trifluoromethyl)-3-(1,1,1-trifluoropropan-2-yl)-1H- pyrazole-5-carboxamido)picolinamide; SC-175 1-((3,3-difluorocyclobutyl)methyl)-3-(1,1-difluoropropan-2-yl)-N-(2-(methylsulfonyl)pyridin- 4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-176 4-(1-((3,3-difluorocyclobutyl)methyl)-3-(1,1-difluoropropan-2-yl)-4-(trifluoromethyl)-1H- pyrazole-5-carboxamido)picolinamide; SC-177 4-(4-chloro-1-((3,3-difluorocyclobutyl)methyl)-3-(1,1-difluoroethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-178 4-chloro-1-((3,3-difluorocyclopentyl)methyl)-3-(1,1-difluoroethyl)-N-(2- (methylsulfonyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide; SC-179 1-((3,3-difluorocyclobutyl)methyl)-3-(1,1-difluoroethyl)-N-(2-(methylsulfonyl)pyridin-4-yl)- 4-(trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-180 4-(1-((3,3-difluorocyclobutyl)methyl)-3-(1,1-difluoroethyl)-4-(trifluoromethyl)-1H-pyrazole- 5-carboxamido)picolinamide; SC-181 1-((3,3-difluorocyclopentyl)methyl)-3-(1,1-difluoroethyl)-N-(2-(methylsulfonyl)pyridin-4-yl)- 4-(trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-182 4-(1-((3,3-difluorocyclopentyl)methyl)-3-(1,1-difluoroethyl)-4-(trifluoromethyl)-1H-pyrazole- 5-carboxamido)picolinamide; SC-183 1-((3,3-difluorocyclobutyl)methyl)-4-methyl-N-(2-(methylsulfonyl)pyridin-4-yl)-3- (perfluoroethyl)-1H-pyrazole-5-carboxamide; SC-184 4-(1-((3,3-difluorocyclobutyl)methyl)-4-methyl-3-(perfluoroethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-185 1-((3,3-difluorocyclopentyl)methyl)-4-methyl-N-(2-(methylsulfonyl)pyridin-4-yl)-3- (perfluoroethyl)-1H-pyrazole-5-carboxamide; SC-186 4-(1-((3,3-difluorocyclopentyl)methyl)-4-methyl-3-(perfluoroethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-187 1-((3,3-difluorocyclobutyl)methyl)-4-methyl-N-(2-(methylsulfonyl)pyridin-4-yl)-3-(1,1,1- trifluoropropan-2-yl)-1H-pyrazole-5-carboxamide; SC-188 4-(1-((3,3-difluorocyclobutyl)methyl)-4-methyl-3-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-5- carboxamido)picolinamide; SC-189 1-((3,3-difluorocyclopentyl)methyl)-4-methyl-N-(2-(methylsulfonyl)pyridin-4-yl)-3-(1,1,1- trifluoropropan-2-yl)-1H-pyrazole-5-carboxamide; SC-190 4-(1-((3,3-difluorocyclopentyl)methyl)-4-methyl-3-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole- 5-carboxamido)picolinamide; SC-191 1-((3,3-difluorocyclobutyl)methyl)-3-(1,1-difluoropropan-2-yl)-4-methyl-N-(2- (methylsulfonyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide; SC-192 4-(1-((3,3-difluorocyclobutyl)methyl)-3-(1,1-difluoropropan-2-yl)-4-methyl-1H-pyrazole-5- carboxamido)picolinamide; SC-193 1-((3,3-difluorocyclopentyl)methyl)-3-(1,1-difluoropropan-2-yl)-4-methyl-N-(2- (methylsulfonyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide; SC-194 4-(1-((3,3-difluorocyclopentyl)methyl)-3-(1,1-difluoropropan-2-yl)-4-methyl-1H-pyrazole-5- carboxamido)picolinamide; SC-195 1-((3,3-difluorocyclopentyl)methyl)-3-(difluoromethoxy)-N-(2-(methylsulfonyl)pyridin-4-yl)- 4-(trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-196 4-(1-((3,3-difluorocyclopentyl)methyl)-3-(difluoromethoxy)-4-methyl-1H-pyrazole-5- carboxamido)picolinamide; SC-197 1-((3,3-difluorocyclopentyl)methyl)-3-(difluoromethoxy)-4-methyl-N-(2- (methylsulfonyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide; SC-198 4-(1-((3,3-difluorocyclopentyl)methyl)-4-methyl-3-(trifluoromethoxy)-1H-pyrazole-5- carboxamido)picolinamide; SC-199 1-((3,3-difluorocyclopentyl)methyl)-4-methyl-N-(2-(methylsulfonyl)pyridin-4-yl)-3- (trifluoromethoxy)-1H-pyrazole-5-carboxamide; SC-200 4-(1-((3,3-difluorocyclopentyl)methyl)-3-(1,1-difluoroethoxy)-4-methyl-1H-pyrazole-5- carboxamido)picolinamide; SC-201 1-((3,3-difluorocyclopentyl)methyl)-3-(1,1-difluoroethoxy)-4-methyl-N-(2- (methylsulfonyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide; SC-202 3-(cyclopropyldifluoromethyl)-1-((3,3-difluorocyclobutyl)methyl)-4-methyl-N-(2- (methylsulfonyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide; SC-203 4-(3-(cyclopropyldifluoromethyl)-1-((3,3-difluorocyclobutyl)methyl)-4-methyl-1H-pyrazole- 5-carboxamido)picolinamide; SC-204 4-(3-(1,1-difluoroethyl)-4-methyl-1-((2-(trifluoromethyl)cyclopropyl)methyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-205 3-(1,1-difluoroethyl)-4-methyl-N-(2-(methylsulfonyl)pyridin-4-yl)-1-((2- (trifluoromethyl)cyclopropyl)methyl)-1H-pyrazole-5-carboxamide; SC-206 4-(3-(1,1-difluoroethyl)-1-((2-(difluoromethyl)cyclopropyl)methyl)-4-methyl-1H-pyrazole-5- carboxamido)picolinamide; SC-207 3-(1,1-difluoroethyl)-1-((2-(difluoromethyl)cyclopropyl)methyl)-4-methyl-N-(2- (methylsulfonyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide; SC-208 4-(1-((3,3-difluoro-1-methyleyclobutyl)methyl)-3-(1,1-difluoroethyl)-4-methyl-1H-pyrazole- 5-carboxamido)picolinamide; SC-209 1-((3,3-difluoro-1-methyleyclobutyl)methyl)-3-(1,1-difluoroethyl)-4-methyl-N-(2- sulfamoylpyridin-4-yl)-1H-pyrazole-5-caiboxamide; SC-210 1-((3,3-difluoro-1-methyleyclobutyl)methyl)-3-(1,1-difluoroethyl)-4-methyl-N-(2- (methylsulfonyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide; SC-211 1-((3,3-difluorocyclopentyl)methyl)-3-(1,1-difluoroethyl)-4-methyl-N-(2-sulfamoylpyridin-4- yl)-1H-pyrazole-5-ca±oxamide; SC-212 1-((3,3-difluoro-1-methylcyclopentyl)methyl)-3-(1,1-difluoroethyl)-4-methyl-N-(2- sulfamoylpyridin-4-yl)-1H-pyrazole-5-caiboxamide; SC-213 1-((3,3-difluoro-1-methylcyclopentyl)methyl)-3-(1,1-difluoroethyl)-4-methyl-N-(2- (methylsulfonyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide; SC-214 4-(1-((3,3-difluoro-1-methyleyclopentyl)methyl)-3-(1,1-difluoroethyl)-4-methyl-1H-pyrazole- 5-carboxamido)picolinamide; SC-215 1-((3,3-difluorocyclobutyl)methyl)-3-(l,1-difluoroethyl)-4-methyl-N-(2-sulfamoylpyridin-4- yl)-1H-pyrazole-5-ca±oxamide; SC-216 4-(3-cyclopropyl-1-((3,3-difluorocyclopentyl)methyl)-4-(difluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-217 4-(1-((4,4-difluoro-2-(trifluoromethyl)cyclopentyl)methyl)-3-(1,1-difluoroethyl)-4-methyl- lH-pyrazole-5-carboxamido)picolinamide; SC-218 4-(1-((3,3-difluorocyclopentyl)methyl)-3-ethyl-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-219 4-(3-cyclopropyl-1-((3-(trifluoromethoxy)cyclobutyl)methyl)-4-(trifluoromethyl)-1H- pyrazole-5-carboxamido)picolinamide; SC-220 1-((3,3-difluoro-1-(trifluoromethyl)cyclobutyl)methyl)-3-(l,l-difluoroethyl)-4-methyl-N-(2- (methylsulfonyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide; SC-221 4-(3-cyclopropyl-1-((3-(difluoromethyl)cyclobutyl)methyl)-4-(trifluoromethyl)-1H-pyrazole- 5-carboxamido)picolinamide; SC-222 1-(1-(3,3-difluorocyclobutyl)ethyl)-3-(1,1-difluoroethyl)-4-methyl-N-(2- (methylsulfonyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide; SC-223 4-(3-(1,1-difluoroethyl)-1-((2-((2-methoxyethoxy)methyl)cyclohexyl)methyl)-4-methyl-1H- pyrazole-5-carboxamido)picolinamide; SC-224 1-((3,4-difluorocyclopentyl)methyl)-3-(1,1-difluoroethyl)-4-methyl-N-(2- (methylsulfonyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide; SC-225 1-((3,3-difluorocyclopentyl)methyl)-3-methoxy-N-(2-(methylsulfonyl)pyridin-4-yl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-226 1-(cyclohexylmethyl)-N-(3-(methylsulfonyl)phenyl)-1H-pyrazole-5-carboxamide; SC-229 1-(cyclohexylmethyl)-4-(difluoromethyl)-N-(3-(methylsulfonyl)phenyl)-1H-pyrazole-5- carboxamide; SC-230 3-cyclopropyl-1-((4,4-difluorocyclohexyl)methyl)-N-(3-sulfamoylphenyl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-231 N-(2-cyanopyridin-4-yl)-1-((4,4-difluorocyclohexyl)methyl)-3,4-dimethyl-1H-pyrazole-5- carboxamide; SC-232 1-((1-methylcyclohexyl)methyl)-N-(3-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-1H- pyrazole-5-carboxamide; SC-233 1-((1-fluorocyclohexyl)methyl)-N-(3-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-1H- pyrazole-5-carboxamide; SC-234 3-methyl-N-(3-(methylsulfonyl)phenyl)-1-(oxetan-3-yimethyl)-4-(trifluoromethyl)-1H- pyrazole-5-carboxamide; SC-235 1-((2,2-difluorocyclopentyl)methyl)-N-(3-sulfamoylphenyl)-4-(trifluoromethyl)-1H-pyrazole- 5-carboxamide; SC-236 4-chloro-1-((4,4-difluorocyclohexyl)methyl)-3-methyl-N-(3-sulfamoylphenyl)-1H-pyrazole- 5-carboxamide; SC-237 3-methyl-N-(3-(methylsulfonyl)phenyl)-1-(oxetan-2-ylmethyl)-4-(trifluoromethyl)-1H- pyrazole-5-carboxamide; SC-238 1-(cyclohexylmethyl)-N-(4-fluoro-3-sulfamoyiphenyl)-3-methyl-4-(trifluoromethyl)-1H- pyrazole-5-carboxamide; SC-239 4-(3-chloro-1-((4,4-difluorocyclohexyl)methyl)-4-methyl-1H-pyrazole-5- carboxamido)picolinamide; SC-241 1-((4,4-difluorocyclohexyl)methyl)-3-methyl-N-(5-(methylsulfonyl)pyridin-3-yl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-242 1-((4,4-difluorocyclohexyl)methyl)-4-methyl-N-(5-sulfamoylpyridin-3-yl)-3- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-243 1-((4,4-difluorocyclohexyl)methyl)-4-methyl-N-(6-sulfamoylpyridin-2-yl)-3- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-244 1-(cyclohexylmethyl)-3-methyl-N-(3-sulfamoylphenyl)-4-(trifluoromethyl)-1H-pyrazole-5- carboxamide; SC-246 3-cyclopropyl-1-((4,4-difluorocyclohexyl)methyl)-N-(2-sulfamoylpyridin-4-yl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-247 5-(1-((3,3-difluorocyclopentyl)methyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)nicotinamide; SC-248 4-(1-((3,3-difluorocyclopentyl)methyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)pyrimidine-2-carboxamide; SC-249 4-(1-((4,4-difluorocyclohexyl)methyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)-5-methylpicolinamide; SC-250 3-cyclopropyl-1-((4,4-difluorocyclohexyl)methyl)-N-(2-(methylsulfonyl)pyridin-4-yl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-251 5-(1-((4,4-difluorocyclohexyl)methyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)-2-methylnicotinamide; SC-252 1-((4,4-difluorocyclohexyl)methyl)-3-methyl-N-(2-methylpyridin-4-yl)-4-(trifluoromethyl)- lH-pyrazole-5-carboxamide; SC-253 6-(1-((4,4-difluorocyclohexyl)methyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-254 1-((3,3-difluorocyclopentyl)methyl)-4-methyl-N-(2-sulfamoylpyridin-4-yl)-3- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-255 1-((1-hydroxycyclohexyl)methyl)-N-(3-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-1H- pyrazole-5-carboxamide; SC-256 2-(1-((4,4-difluorocyclohexyl)methyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)oxazole-5-carboxamide; SC-257 5-(1-((4,4-difluorocyclohexyl)methyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-258 4-(3-cyclopropyl-1-((tetrahydro-2H-pyran-2-yl)methyl)-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-259 3-cyclopropyl-N-(2-(methylsulfonyl)pyridin-4-yl)-1-((tetrahydro-2H-pyran-2-yl)methyl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-260 4-(1-((4,4-difluorocyclohexyl)methyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)-N-methylpicolinamide; SC-261 4-(4-chloro-3-cyclopropyl-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-262 1-((3,3-difluorocyclopentyl)methyl)-3-(difluoromethyl)-N-(3-sulfamoylphenyl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-263 3-cyclopropyl-N-(2-(methylsulfonyl)pyridin-4-yl)-1-((tetrahydrofuran-2-yl)methyl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-264 3-cyclopropyl-N-(3-sulfamoylphenyl)-1-((tetrahydro-2H-pyran-2-yl)methyl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-265 1-((3,3-difluorocyclopentyl)methyl)-3-methoxy-N-(3-sulfamoylphenyl)-4-(trifluoromethyl)- 1H-pyrazole-5-carboxamide; SC-266 4-(3-cyclopropyl-1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-267 4-(1-((4,4-difluorocyclohexyl)methyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)-6-methylpicolinamide; SC-268 2-(1-((4,4-difluorocyclohexyl)methyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)-5-fluoroisonicotinamide; SC-269 4-(1-((3,3-difluorocyclopentyl)methyl)-4-methoxy-3-(trifluoromethyl)-lH-pyrazole-5- carboxamido)picolinamide; SC-271 4-(1-((3,3-difluorocyclopentyl)methyl)-3-(1,1-difluoroethyl)-4-methoxy-1H-pyrazole-5- carboxamido)picolinamide; SC-273 4-(1-((3,3-difluorocyclopentyl)methyl)-3-methoxy-4-(trifluoromethyl)-lH-pyrazole-5- carboxamido)picolinamide; SC-274 N-(3-carbamoyl-4-fluorophenyl)-3-cyclopropyl-1-((3,3-difluorocyclobutyl)methyl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-275 3-cyclopropyl-1-((3,3-difluorocyclopentyl)methyl)-4-(difluoromethyl)-N-(2- (methylsulfonyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide; SC-276 3-cyclopropyl-1-((3,3-difluorocyclobutyl)methyl)-N-(3-sulfamoylphenyl)-4-(trifluoromethyl)- lH-pyrazole-5-carboxamide; SC-277 3-cyclopropyl-1-((3,3-difluorocyclopentyl)methyl)-N-(2-(methylsulfonyl)pyridin-4-yl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-278 4-(1-((2,2-difluorocyclobutyl)methyl)-4-methyl-3-(perfluoroethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-279 4-(3-cyclopropyl-1-((2,2-difluorocyclopropyl)methyl)-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-280 1-((4,4-difluorocyclohexyl)methyl)-3-methyl-N-(6-(methylsulfonyl)pyridazin-4-yl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-281 4-(3-cyclopropyl-1-((3-methoxycyclobutyl)methyl)-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-282 3-cyclopropyl-1-((3,3-difluorocyclobutyl)methyl)-N-(2-sulfamoylpyridin-4-yl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-283 4-(3-(3,3-difluorocyclobutoxy)-1-((3,3-difluorocyclopentyl)methyl)-4-(trifluoromethyl)-1H- pyrazole-5-carboxamido)picolinamide; SC-284 4-(3-cyclopropyl-4-(trifluoromethyl)-1-((5-(trifluoromethyl)tetrahydrofuran-2-yl)methyl)-1H- pyrazole-5-carboxamido)picolinamide; SC-286 3-cyclopropyl-N-(2-(methylsulfonyl)pyridin-4-yl)-1-((5-methyltetrahydrofuran-2-yl)methyl)- 4-(trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-289 4-(1-((4,4-difluorocyclohexyl)methyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)-3-fluoropicolinamide; SC-290 3-cyclopropyl-1-((3-(difluoromethoxy)cyclobutyl)methyl)-N-(2-(methyIsulfonyl)pyridin-4- yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-291 4-(3-cyclopropyl-1-((2,2,3,3-tetrafluorocyclobutyl)methyl)-4-(trifluoromethyl)-1H-pyrazole- 5-carboxamido)picolinamide; SC-293 1-((3,3-difluorocyclopentyl)methyl)-3-(difluoromethoxy)-N-(2-(methylsulfonyl)pyridin-4-yl)- 4-(trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-294 4-(1-((4,4-difluorocyclohexyl)methyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)-3-methylpicolinamide; SC-295 1-((3,3-difluorocyclobutyl)methyl)-3-(l,1-difluoroethyl)-4-methyl-N-(3-sulfamoylphenyl)- lH-pyrazole-5-carboxamide; SC-296 1-((3,3-difluorocyclopentyl)methyl)-3-(1,1-difluoroethyl)-4-methyl-N-(3-sulfamoylphenyl)- lH-pyrazole-5-carboxamide; SC-297 1-((3,3-difluorocyclopentyl)methyl)-3-ethyl-N-(2-(methylsulfonyl)pyridin-4-yl)-4- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-298 4-(3-cyclopropyl-1-((3,3-difluorocyclopentyl)methyl)-4-(2,2,2-trifluoroethoxy)-1H-pyrazole- 5-carboxamido)picolinamide; SC-299 4-(1-((3,3-difluoro-1-(trifluoromethyl)cyclobutyl)methyl)-3-(1,1-difluoroethyl)-4-methyl-1H- pyrazole-5-carboxamido)picolinamide; SC-301 4-(3-(1,1-difluoroethyl)-1-((3-fluorocyclobutyl)methyl)-4-methyl-1H-pyrazole-5- carboxamido)picolinamide; SC-302 1-((3,3-difluorocyclobutyl)methyl)-3-ethyl-4-methyl-N-(2-(methylsulfonyl)pyridin-4-yl)-1H- pyrazole-5-carboxamide; SC-303 1-((3,3-difluorocyclobutyl)methyl)-3-(l,1-difluoroethyl)-N-(2-(methylsulfinyl)pyridin-4-yl)- 4-(trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-304 1-((3,3-difluorocyclopentyl)methyl)-3-methyl-N-(3-sulfamoylphenyl)-4-(trifluoromethoxy)- lH-pyrazole-5-carboxamide; SC-305 3-cyclopropyl-N-(2-(methylsulfonyl)pyridin-4-yl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-4- (2,2,2-trifluoroethyl)-1H-pyrazole-5-carboxamide; SC-308 3-(1,1-difluoroethyl)-1-((1-methoxycyclopropyl)methyl)-4-methyl-N-(2-sulfamoylpyridin-4- yl)-1H-pyrazole-5-carboxamide; SC-309 4-(1-((3,3-difluorocyclobutyl)methyl)-3-(1,1-difluoroethoxy)-4-methyl-1H-pyrazole-5- carboxamido)picolinamide; SC-310 3-(1,1-difluoroethyl)-1-((1-fluorocyclopropyl)methyl)-4-methyl-N-(2-sulfamoylpyridin-4-yl)- lH-pyrazole-5-carboxamide; SC-311 4-(3-(1,l-difluoroethyl)-1-((1-(difluoromethyl)-3,3-difluorocyclobutyl)methyl)-4-methyl-1H- pyrazole-5-carboxamido)picolinamide; SC-312 3-(1,1-difluoroethyl)-4-methyl-1-((2-methyltetrahydro-2H-pyran-2-yl)methyl)-N-(2- sulfamoylpyridin-4-yl)-1H-pyrazole-5-caiboxamide; SC-313 3-(1,1-difluoroethyl)-4-methyl-1-((1-methylcyclopropyl)methyl)-N-(2-sulfamoylpyridin-4- yl)-1H-pyrazole-5-carboxamide; SC-314 3-(1,1-difluoroethyl)-4-methyl-1-((2-methylcyclopropyl)methyl)-N-(2-sulfamoylpyridin-4- yl)-1H-pyrazole-5-carboxamide; SC-315 4-(3-(1,1-difluoroethyl)-4-methyl-1-((2-(trifluoromethyl)cyclobutyl)methyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-316 3-(1,1-difluoroethyl)-1-((1-(difluoromethyl)-3,3-difluorocyclobutyl)methyl)-4-methyl-N-(2- sulfamoylpyridin-4-yl)-1H-pyrazole-5-carboxamide; SC-317 3-(1,1-difluoroethyl)-4-methyl-1-((2-methyloxetan-2-yl)methyl)-N-(2-sulfamoylpyridin-4-yl)- lH-pyrazole-5-carboxamide; SC-318 4-(1-((3,3-difluorocyclobutyl)methyl)-4-methyl-3-(trifluoromethoxy)-1H-pyrazole-5- carboxamido)picolinamide; SC-319 3-(1,1-difluoroethyl)-4-methyl-1-((2-methyltetrahydrofuran-2-yl)methyl)-N-(2- sulfamoylpyridin-4-yl)-1H-pyrazole-5-caiboxamide; SC-320 1-((4,4-difluorocyclohexyl)methyl)-4-methyl-N-(2-sulfamoylpyridin-4-yl)-3- (trifluoromethyl)-1H-pyrazole-5-carboxamide; SC-321 5-(1-((4,4-difluorocyclohexyl)methyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)pyridazine-3-carboxamide; SC-322 3-cyclopropyl-4-(difluoromethoxy)-N-(2-(methylsulfonyl)pyridin-4-yl)-1-((tetrahydro-2H- pyran-4-yl)methyl)-1H-pyrazole-5-carboxamide; SC-323 1-((3,3-difluorocyclobutyl)methyl)-3-(difluoromethoxy)-4-methyl-N-(2- (methylsulfonyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide; SC-324 4-(1-((3,3-difluorocyclobutyl)methyl)-3-(difluoromethyl)-4-(trifluoromethyl)-1H-pyrazole-5- carboxamido)picolinamide; SC-325 4-(1-((3,3-difluorocyclopentyl)methyl)-3-(difluoromethyl)-4-(trifluoromethyl)-lH-pyrazole-5- carboxamido)picolinamide; in the form of the free compound or a physiologically acceptable salt thereof. ### Claim 13 (depends on 1) A pharmaceutical dosage form comprising a compound according to claim 1. ### Claim 14 (depends on 12) A pharmaceutical dosage form comprising a compound according to claim 12. ### Claim 15 (depends on 1) A method of treating pain comprising administering to a subject in need thereof an effective amount therefor of a compound according to claim 1. ### Claim 16 (depends on 12) A method of treating pain comprising administering to a subject in need thereof an effective amount therefor of a compound according to claim 12.