# US 11,998,921 B2 · Immuno histo chemistry tissue processing system > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,998,921 B2 - Document ID: US11998921B2 - Status: Granted - Kind: B2 - Application number: 17/340,595 - Filed: 2021-06-07 - Published: 2021-09-23 - Granted: 2024-06-04 - Earliest claimed: 2019-09-06 - Assignees: Rushabh Instruments, LLC - Applicants: Rushabh Instruments, LLC - Inventors: Preyas Shah; Sahil Shah - Web page: https://patentgrep.com/patent/US11998921B2 ## CPC - B01L 9/52: {Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips} - B01L 3/502: {with fluid transport, e.g. in multi-compartment structures} - G01N 1/312: {for samples mounted on planar substrates} - B01L 2200/025: Align devices or objects to ensure defined positions relative to each other - B01L 2200/026: Fluid interfacing between devices or objects, e.g. connectors, inlet details - B01L 2200/04: Exchange or ejection of cartridges, containers or reservoirs - B01L 2200/082: Handling hazardous material - B01L 2200/087: Ergonomic aspects - B01L 2200/143: Quality control, feedback systems - B01L 2200/147: Employing temperature sensors - B01L 2200/16: Reagents, handling or storing thereof - B01L 2200/18: Transport of container or devices - B01L 2300/021: Identification, e.g. bar codes - B01L 2300/0609: Holders integrated in container to position an object - B01L 2300/0627: Sensor or part of a sensor is integrated - B01L 2300/069: Absorbents; Gels to retain a fluid - B01L 2300/0822: Slides - B01L 2300/0877: Flow chambers - B01L 2400/0457: passive flow or gravitation - B01L 2400/0478: pistons - B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) ## Abstract A tissue processing system for processing a laboratory slide includes a slide holder for holding the slide, an outlet port positioned to direct a fluid stream onto the slide, and a device for moving the slide holder relative to the outlet port, or vice versa, to adjust a point on the slide at which the fluid stream is delivered onto the laboratory slide. The slide holder includes an absorbent pad configured to be positioned between one wall of the plurality of walls and a free edge of the slide for absorbing fluid travelling along the slide. A manifold of the system includes a first outlet port that directs a first fluid stream from a first fluid passageway onto the slide, and a second outlet port that directs a second fluid stream from a second fluid passageway onto a location of the slide that differs from the first fluid stream. ## Claims ### Claim 1 A slide holder assembly for holding a laboratory slide, said slide holder assembly comprising: (a) a body having a plurality of walls including a bottom wall and a plurality of sidewalls extending vertically with respect to the bottom wall; wherein one wall of said plurality of sidewalls forms a vertically oriented sidewall against which a horizontally oriented laboratory slide can abut, and said one wall includes (i) an exit port which is integrated within said one wall and disposed at an elevation beneath the slide and (ii) a channel, in the form of an indented portion that is integrally formed on said one wall and intersects the exit port, that is configured to transfer waste fluid from the slide to the exit port, wherein the indented portion on said one wall extends to an elevation above the exit port on said one wall for channeling the waste fluid under gravity toward the exit port, and, wherein the indented portion and the exit port are disposed at an elevation above the bottom wall, wherein the body has an open and uncovered top side that is opposite the bottom wall and through which open and uncovered top side fluid can be delivered onto the slide, and (b) an absorbent pad configured to be positioned between said one wall and a free edge of the laboratory slide, wherein the indented portion is configured to prevent the absorbent pad from entering therewithin. ### Claim 2 (depends on 1) The slide holder assembly of claim 1, further comprising a handle extending from said body for grasping by a user. ### Claim 3 (depends on 1) The slide holder assembly of claim 1, wherein said exit port is formed at least partially in said indented portion. ### Claim 4 (depends on 1) The slide holder assembly of claim 1, wherein said body, at an area including said one wall, extends to an elevation above a remaining portion of the body in order to limit the waste fluid from escaping from the body. ### Claim 5 (depends on 1) The slide holder assembly of claim 1, wherein the bottom wall of the plurality of walls of the body includes a cutout for accommodating a heater for the laboratory slide. ### Claim 6 (depends on 5) The slide holder assembly of claim 5, further comprising a wall or a seal that extends about a perimeter of the cutout to prevent the passage of fluid residing on the lower wall onto the heater. ### Claim 7 (depends on 1) The slide holder assembly of claim 1, wherein the indented portion comprises a series of interconnected indents extending in different directions. ### Claim 8 (depends on 1) The slide holder assembly of claim 1, wherein the indented portion comprises a series of interconnected indents having a ladder shape. ### Claim 9 (depends on 1) The slide holder assembly of claim 1, wherein the indented portion is disposed on one side of said one wall, and a separate port is connected to the exit port on an opposing side of said one wall. ### Claim 10 (depends on 1) The slide holder assembly of claim 1, further comprising a protruding shelf integrated on said one wall at an elevation above said indented portion. ### Claim 11 (depends on 10) The slide holder assembly of claim 10, wherein the slide is positionable between the indented portion and the shelf. ### Claim 12 (depends on 1) The slide holder assembly of claim 1, wherein the indented portion is a semi-circular depression formed on a surface of said one wall. ### Claim 13 (depends on 1) The slide holder assembly of claim 1, wherein the indented portion has a triangular shape and multiple protrusions disposed within the indented portion. ### Claim 14 (depends on 1) The slide holder assembly of claim 1, wherein the exit port is disposed at a lowermost elevation of the indented portion. ### Claim 15 (depends on 1) The slide holder assembly of claim 1, wherein the exit port extends orthogonally to the indented portion. ### Claim 16 (depends on 1) The slide holder assembly of claim 1, wherein the exit port is oriented horizontally through said one wall. ### Claim 17 (depends on 1) The slide holder assembly of claim 1, wherein the indented portion extends only partially through said one wall and the exit port extends fully through said one wall. ### Claim 18 (depends on 6) A slide carriage comprising (i) a body for receiving the slide holder assembly of claim 6, and (ii) a heating element connected to the body for heating the slide within the slide holder assembly, wherein the heating element is positionable at an elevation beneath the slide.