# US 11,998,916 B2 · Dual balance electrodynamic trap with enhanced safety and modularity

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 11,998,916 B2
- Document ID: US11998916B2
- Status: Granted
- Kind: B2
- Application number: 18/136,829
- Filed: 2023-04-19
- Published: 2023-10-19
- Granted: 2024-06-04
- Earliest claimed: 2022-04-19
- Assignees: Microlev LLC
- Applicants: Microlev LLC
- Inventors: Josefina Hajek-Herrera; David Woolley; Ryan Davis
- Web page: https://patentgrep.com/patent/US11998916B2

## CPC

- B01L 3/502784: {specially adapted for droplet or plug flow, e.g. digital microfluidics}
- G01N 15/1425: {using an analyser being characterised by its control arrangement}
- B01L 3/561: {Tubes; Conduits}
- B01L 2200/0626: using levitated droplets
- B01L 2400/0415: electrical forces, e.g. electrokinetic
- G01N 2015/0026: {in gas, e.g. fog}
- G01N 2015/0046: {in gas, e.g. smoke}
- B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

A dual balance electrode trap having an outer chamber, a droplet dispenser holder removably coupled to the top surface of the outer chamber, and a rod holder having a central opening and four peripheral openings that are sized and shaped to allow four respective quadrupole metal rods to pass therethrough. The droplet dispenser holder has a top surface, a bottom surface, and a through hole that extends from the dispenser holder top surface to the droplet dispenser bottom surface. The through hole has a larger diameter portion adjacent to the top surface and a smaller diameter portion adjacent to the bottom surface, thereby preventing a droplet dispenser distal tip from extending entirely through the hole and contacting electrodes in the DBET. The rod holder is configured to be removably coupled to the quadrupole metal rods so that a location of the rod holder relative to the metal rods is adjustable.

## Claims

### Claim 1

An apparatus for use in a dual balance electrode trap, the apparatus comprising:
an outer chamber comprising a top surface, a bottom surface, at least one sidewall surface extending between the top surface and the bottom surface, at least one optical port in the sidewall surface, and a plurality of electrical feedthrough ports in the sidewall surface;
a droplet dispenser holder removably coupled to the top surface of the outer chamber, wherein the droplet dispenser holder comprises a top surface, a bottom surface, and a through hole that extends from the dispenser holder top surface to the droplet dispenser bottom surface, and wherein the through hole has a larger diameter portion adjacent to the droplet dispenser holder top surface and a smaller diameter portion adjacent to the droplet dispenser holder bottom surface; and
a rod holder comprising a central opening and four peripheral openings that are sized and shaped to allow four respective quadrupole metal rods to pass therethrough,
wherein the rod holder is configured to be removably coupled to the quadrupole metal rods so that a location of the rod holder relative to the metal rods is adjustable, and
wherein the droplet dispenser holder further comprises a threaded opening in communication with the larger diameter portion of the through hole, wherein the threaded opening is sized and shaped to allow a set screw to pass therethrough in order to hold a distal end of a droplet dispenser in place relative to the droplet dispenser holder.

### Claim 2 (depends on 1)

The apparatus of claim 1, wherein the outer chamber comprises four sidewall surfaces, each one of the sidewall surfaces having an optical port.

### Claim 3

An apparatus for use in a dual balance electrode trap, the apparatus comprising:
an outer chamber comprising a top surface, a bottom surface, at least one sidewall surface extending between the top surface and the bottom surface, at least one optical port in the sidewall surface, and a plurality of electrical feedthrough ports in the sidewall surface;
a droplet dispenser holder removably coupled to the top surface of the outer chamber, wherein the droplet dispenser holder comprises a top surface, a bottom surface, and a through hole that extends from the dispenser holder top surface to the droplet dispenser bottom surface, and wherein the through hole has a larger diameter portion adjacent to the droplet dispenser holder top surface and a smaller diameter portion adjacent to the droplet dispenser holder bottom surface; and
a rod holder comprising a central opening and four peripheral openings that are sized and shaped to allow four respective quadrupole metal rods to pass therethrough,
wherein the rod holder is configured to be removably coupled to the quadrupole metal rods so that a location of the rod holder relative to the metal rods is adjustable, and
wherein the rod holder further comprises four threaded openings, each one of the four threaded openings being in communication with a respective one of the four peripheral openings, and wherein the four threaded openings are sized and shaped to allow a set screw to pass therethrough in order to hold the four respective quadrupole metal rods in place relative to the rod holder.

### Claim 4

An apparatus for use in a dual balance electrode trap, the apparatus comprising:
an outer chamber comprising a top surface, a bottom surface, at least one sidewall surface extending between the top surface and the bottom surface, at least one optical port in the sidewall surface, and a plurality of electrical feedthrough ports in the sidewall surface;
a droplet dispenser holder removably coupled to the top surface of the outer chamber, wherein the droplet dispenser holder comprises a top surface, a bottom surface, and a through hole that extends from the dispenser holder top surface to the droplet dispenser bottom surface, and wherein the through hole has a larger diameter portion adjacent to the droplet dispenser holder top surface and a smaller diameter portion adjacent to the droplet dispenser holder bottom surface; and
a rod holder comprising a central opening and four peripheral openings that are sized and shaped to allow four respective quadrupole metal rods to pass therethrough,
wherein the rod holder is configured to be removably coupled to the quadrupole metal rods so that a location of the rod holder relative to the metal rods is adjustable, and
wherein the droplet dispenser holder is made of a non-conducting material.

### Claim 5 (depends on 1)

The apparatus of claim 1, wherein the rod holder is made of a non-conducting material.

### Claim 6

An apparatus for use in a dual balance electrode trap, the apparatus comprising:
an outer chamber comprising a top surface, a bottom surface, at least one sidewall surface extending between the top surface and the bottom surface, at least one optical port in the sidewall surface, and a plurality of electrical feedthrough ports in the sidewall surface;
a droplet dispenser holder removably coupled to the top surface of the outer chamber, wherein the droplet dispenser holder comprises a top surface, a bottom surface, and a through hole that extends from the dispenser holder top surface to the droplet dispenser bottom surface, and wherein the through hole has a larger diameter portion adjacent to the droplet dispenser holder top surface and a smaller diameter portion adjacent to the droplet dispenser holder bottom surface; and
a plurality of rod holders, each one of the rod holders comprising a central opening and four peripheral openings that are sized and shaped to allow four respective quadrupole metal rods to pass therethrough,
wherein the plurality of rod holders is configured to be removably coupled to the quadrupole metal rods at a respective plurality of locations along a length of the quadrupole metal rods so that locations of the rod holders relative to the metal rods is adjustable.

### Claim 7 (depends on 1)

The apparatus of claim 1, wherein the at least one sidewall surface of the outer chamber comprises two gas flow ports that are smaller than the at least one optical port.

### Claim 8 (depends on 1)

The apparatus of claim 1, wherein the at least one optical port comprises a transparent, airtight window for allowing a levitating droplet to be viewed from outside of the outer chamber.

### Claim 9 (depends on 3)

The apparatus of claim 3, wherein the outer chamber comprises four sidewall surfaces, each one of the sidewall surfaces having an optical port.

### Claim 10 (depends on 3)

The apparatus of claim 3, wherein the rod holder is made of a non-conducting material.

### Claim 11 (depends on 3)

The apparatus of claim 3, wherein the at least one sidewall surface of the outer chamber comprises two gas flow ports that are smaller than the at least one optical port.

### Claim 12 (depends on 3)

The apparatus of claim 3, wherein the at least one optical port comprises a transparent, airtight window for allowing a levitating droplet to be viewed from outside of the outer chamber.

### Claim 13 (depends on 4)

The apparatus of claim 4, wherein the outer chamber comprises four sidewall surfaces, each one of the sidewall surfaces having an optical port.

### Claim 14 (depends on 4)

The apparatus of claim 4, wherein the rod holder is made of a non-conducting material.

### Claim 15 (depends on 4)

The apparatus of claim 4, wherein the at least one sidewall surface of the outer chamber comprises two gas flow ports that are smaller than the at least one optical port.

### Claim 16 (depends on 4)

The apparatus of claim 4, wherein the at least one optical port comprises a transparent, airtight window for allowing a levitating droplet to be viewed from outside of the outer chamber.

### Claim 17 (depends on 6)

The apparatus of claim 6, wherein the outer chamber comprises four sidewall surfaces, each one of the sidewall surfaces having an optical port.

### Claim 18 (depends on 6)

The apparatus of claim 6, wherein each one of the rod holders is made of a non-conducting material.

### Claim 19 (depends on 6)

The apparatus of claim 6, wherein the at least one sidewall surface of the outer chamber comprises two gas flow ports that are smaller than the at least one optical port.

### Claim 20 (depends on 6)

The apparatus of claim 6, wherein the at least one optical port comprises a transparent, airtight window for allowing a levitating droplet to be viewed from outside of the outer chamber.
