Fluidic devices with reaction wells and constriction channels and uses thereof
AssigneeUnchained Labs
InventorDeepak Solomon
Life of this patent
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Abstract
The present disclosure provides fluidic devices and fluidic device assemblies, including microfluidic devices and cartridges comprising the same, that in illustrative embodiments, can be used to make particles or protein precipitates, or to monitor precipitate formation. The fluidic devices typically include channels that connect a reaction well to an inlet port and an outlet port, and a fluidic constriction channel that is configured to help retain fluids in the reaction well and/or promote mixing within the reaction well. In some aspect, fluidic devices are interconnected into fluidic assemblies that can be used in continuous process methods.
Claims15
A fluidic device assembly comprising at least two microfluidic devices in a disposable cartridge, wherein each fluidic device comprises:
- a) a first port;
- b) a first fluid transport channel in fluid connection with:
- i. the first port;
- ii. a reaction well;
- and
- iii. an overflow channel;
- c) a second fluid transport channel in direct fluid communication with the overflow channel;
- d) a fluidic constriction channel in direct fluid communication with the reaction well and the second fluid transport channel;
- and
- e) a second port in direct fluid communication with the second fluid transport channel.
A method for producing a reaction product using a fluidic device assembly, the fluidic device assembly comprising at least two microfluidic devices in a disposable cartridge, wherein each fluidic device comprises:
- a) a first port;
- b) a first fluid transport channel in fluid connection with:
- i. the first port;
- ii. a reaction well;
- and
- iii. an overflow channel;
- c) a second fluid transport channel in direct fluid communication with the overflow channel;
- d) a fluidic constriction channel in direct fluid communication with the reaction well and the second fluid transport channel;
- and
- e) a second port in direct fluid communication with the second fluid transport channel, and
- wherein the method comprises:
- a) introducing a first fluid into the first fluidic channel of each of the at least two fluidic devices;
- b) introducing a second fluid into the first fluidic channel of each of the at two fluidic devices;
- and
- c) producing a reaction product by mixing the first fluid and the second fluid in the reaction well of each of the at least two fluidic devices.
Dependencies are inferred from the claim text.