# US 11,998,754 B2 · Methods and devices for using pulsed radiofrequency electromagnetic field stimulation to reduce inflammation

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- Number: US 11,998,754 B2
- Document ID: US11998754B2
- Status: Granted
- Kind: B2
- Application number: 17/327,279
- Filed: 2021-05-21
- Published: 2022-11-24
- Granted: 2024-06-04
- Earliest claimed: 2021-05-21
- Assignees: Electro Cellular Healthcare Solutions LLC
- Applicants: Electro Cellular Healthcare Solutions LLC
- Inventors: Norton Herrick; Miles Herrick; Sean Hagberg; David Muehsam; David Saloff
- Web page: https://patentgrep.com/patent/US11998754B2

## CPC

- A61N 2/02: using magnetic fields produced by coils, including single turn loops or electromagnets (A61N2/12 takes precedence)
- A61H 23/0218: {with alternating magnetic fields producing a translating or oscillating movement}
- A61N 2/004: {specially adapted for a specific therapy}
- A61N 5/0613: {Apparatus adapted for a specific treatment}
- A61H 2201/5005: for controlling frequency distribution, modulation or interference of a driving signal
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- A61H: PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY (electrotherapy, magnetotherapy, radiation therapy or ultrasound therapy A61N)

## Abstract

Methods and devices for reducing inflammation, reducing pro-inflammatory cytokines molecules and increasing anti-inflammatory signaling molecules in a mammal is provided. In at least one embodiment, a device comprising, a power supply; an amplifier; an antenna and a waveform generator is provided and the one or more signals have an aperiodic continuous waveform function or an aperiodic pulse train that reduce inflammation, reduce pro-inflammatory cytokines molecules and/or increases anti-inflammatory signaling molecules in a mammal.

## Claims

### Claim 1

A method comprising providing one or more signals having an aperiodic continuous waveform to a mammal, wherein the one or more signals reduce inflammation in the mammal by reducing pro-inflammatory cytokines.

### Claim 2 (depends on 1)

The method of claim 1, wherein the one or more signals deliver at least three stimulation events that each have a different peak amplitude level.

### Claim 3 (depends on 1)

The method claim 1, wherein the one or more signals deliver at least two stimulation events that have peak amplitudes separated by 10 nanoseconds to one second.

### Claim 4 (depends on 1)

The method of claim 1, wherein the one or more signals deliver at least 400 stimulation events during a one second interval.

### Claim 5 (depends on 1)

The method of claim 1, wherein the one or more signals deliver at least eight stimulation events that each have a 2 msec pulse duration.

### Claim 6 (depends on 1)

The method of claim 1, wherein the one or more signals are provided to the mammal with a peak magnetic field level between 50 pT and 200 μT.

### Claim 7 (depends on 1)

The method of claim 1, wherein the one or more signals are provided to the mammal with two or more local peak magnetic field levels, wherein a local peak magnetic field level of the two or more local peak magnetic field levels is less than 10 μT.

### Claim 8 (depends on 1)

The method of claim 1, wherein a frequency of the one or more signals is between 1/100 Hz and 100 MHz.

### Claim 9 (depends on 1)

The method of claim 1, wherein the one or more signals are generated using one or more aperiodic continuous waveform functions.

### Claim 10 (depends on 1)

The method of claim 1, wherein the one or more signals deliver at least two stimulation events to the mammal within a time interval between 10 nanoseconds and 100 seconds.

### Claim 11 (depends on 1)

The method of claim 1, wherein the pro-inflammatory cytokines comprise IL-1a, IL-1b, IL-6, or TNF-a.