# US 11,998,747 B2 · Customizable titration for an implantable neurostimulator > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,998,747 B2 - Document ID: US11998747B2 - Status: Granted - Kind: B2 - Application number: 17/521,496 - Filed: 2021-11-08 - Published: 2022-03-03 - Granted: 2024-06-04 - Earliest claimed: 2017-09-14 - Assignees: LivaNova USA, Inc. - Applicants: LivaNova USA, Inc. - Inventors: Scott Stubbs; Imad Libbus; Scott Mazar; Bruce KenKnight; Badri Amurthur - Web page: https://patentgrep.com/patent/US11998747B2 ## CPC - A61N 1/36139: {with automatic adjustment} - A61N 1/37235: {Aspects of the external programmer} - G16H 20/30: relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising - A61N 1/36114: {Cardiac control, e.g. by vagal stimulation (stimulating the heart A61N1/362)} - A61N 1/36132: {using patient feedback} - A61N 1/36157: {Current (A61N1/3616 takes precedence)} - A61N 1/36171: {Frequency} - A61N 1/36175: {Pulse width or duty cycle} - A61N 1/365: controlled by a physiological parameter, e.g. heart potential {(evoked response A61N1/371)} - A61N 1/37223: {Circuits for electromagnetic coupling} - A61N 1/37247: {User interfaces, e.g. input or presentation means} - G16H 40/63: for local operation - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract A programmer configured to collect data from an implantable pulse generator about ongoing neurostimulation being applied during a stimulation titration process by the implantable pulse generator while in communication with the communication circuitry; display, via a user interface, an indication relating to a timing of neurostimulation bursts applied by the implantable pulse generator while in communication with the communication circuitry based on the collected data, the indication being displayed according to a time delay that accounts for a transport delay between the implantable pulse generator and the programmer such that the indication displayed coincides with an actual application of each stimulation burst by the implantable pulse generator; and adjust at least one stimulation parameter applied during the stimulation titration process by the implantable pulse generator. ## Claims ### Claim 1 A programmer configured to communicate with an implantable pulse generator that provides neurostimulation, the programmer comprising: communication circuitry; a user interface; a processor; and a memory having instructions stored thereon that, when executed by the processor, cause the processor to: collect, via the communication circuitry, data from the implantable pulse generator about ongoing neurostimulation being applied during a stimulation titration process by the implantable pulse generator while in communication with the communication circuitry; display, via the user interface, an indication relating to a timing of neurostimulation bursts applied by the implantable pulse generator while in communication with the communication circuitry based on the collected data, the indication being displayed according to a time delay that accounts for a transport delay between the implantable pulse generator and the programmer such that the indication displayed coincides with an actual application of each stimulation burst by the implantable pulse generator; and adjust, via the communication circuitry, at least one stimulation parameter applied by the implantable pulse generator during the stimulation titration process. ### Claim 2 (depends on 1) The programmer of claim 1, wherein the indication comprises a countdown time until a subsequent neurostimulation burst. ### Claim 3 (depends on 1) The programmer of claim 1, wherein the indication comprises at least one of a therapy on indication or a therapy off indication. ### Claim 4 (depends on 1) The programmer of claim 1, wherein the instructions further cause the processor to display the indication in real time. ### Claim 5 (depends on 1) The programmer of claim 1, wherein the collected data includes timing data for future neurostimulation bursts to be applied by the implantable pulse generator, and wherein the instructions further cause the processor to synchronously display, via the user interface, an indication relating to a timing of the future neurostimulation bursts as the future neurostimulation bursts are applied by the implantable pulse generator. ### Claim 6 (depends on 1) The programmer of claim 1, wherein the instructions further cause the processor to: query, via the communication circuitry, the implantable pulse generator to receive a block of timing data; receive, via the communication circuitry, the block of timing data from the implantable pulse generator; and continue to display, via the user interface, the indication relating to the timing of neurostimulation bursts applied by the implantable pulse generator based on the block of timing data after ceasing communication between the communication circuitry and the implantable pulse generator. ### Claim 7 A method of delivering neurostimulation to a patient from an implantable pulse generator, the method comprising: collecting, via communication circuitry of a programmer, data from the implantable pulse generator about ongoing neurostimulation being applied during a stimulation titration process by the implantable pulse generator while in communication with the communication circuitry; displaying, via a user interface of the programmer, an indication relating to a timing of neurostimulation bursts applied by the implantable pulse generator while in communication with the communication circuitry based on the collected data, the indication being displayed according to a time delay that accounts for a transport delay between the implantable pulse generator and the programmer such that the indication displayed coincides with an actual application of each stimulation burst by the implantable pulse generator; and adjusting, via the communication circuitry, at least one stimulation parameter applied by the implantable pulse generator during the stimulation titration process. ### Claim 8 (depends on 7) The method of claim 7, wherein the indication comprises a countdown time until a subsequent neurostimulation burst. ### Claim 9 (depends on 7) The method of claim 7, wherein the indication comprises at least one of a therapy on indication or a therapy off indication. ### Claim 10 (depends on 7) The method of claim 7, wherein the indication is displayed in real time. ### Claim 11 (depends on 7) The method of claim 7, wherein the collected data includes timing data for future neurostimulation bursts to be applied by the implantable pulse generator, and the method further comprises: synchronously displaying, via the user interface of the programmer, an indication relating to a timing of the future neurostimulation bursts as the future neurostimulation bursts are applied by the implantable pulse generator. ### Claim 12 (depends on 7) The method of claim 7, wherein the method further comprises: querying, via the communication circuitry of the programmer, the implantable pulse generator to receive a block of timing data; receiving, via the communication circuitry of the programmer, the block of timing data from the implantable pulse generator; and continuing to display, via the user interface of the programmer, the indication relating to the timing of neurostimulation bursts applied by the implantable pulse generator based on the block of timing data after ceasing communication between the programmer and the implantable pulse generator. ### Claim 13 A neurostimulation system configured to deliver neurostimulation to a patient, the neurostimulation system comprising: an implantable pulse generator configured to deliver the neurostimulation to the patient; a programmer configured to: collect, via communication circuitry of the programmer, data from the implantable pulse generator about ongoing neurostimulation being applied during a stimulation titration process by the implantable pulse generator while in communication with the communication circuitry; and display, via a user interface of the programmer, an indication relating to a timing of neurostimulation bursts applied by the implantable pulse generator while in communication with the communication circuitry based on the collected data, the indication being displayed according to a time delay that accounts for a transport delay between the implantable pulse generator and the programmer such that the indication displayed coincides with an actual application of each stimulation burst by the implantable pulse generator; and adjust, via the communication circuitry, at least one stimulation parameter applied by the implantable pulse generator during the stimulation titration process. ### Claim 14 (depends on 13) The neurostimulation system of claim 13, wherein the indication comprises a countdown time until a subsequent neurostimulation burst.