# US 11,998,742 B1 · Antiviral digital device > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,998,742 B1 - Document ID: US11998742B1 - Status: Granted - Kind: B1 - Application number: 18/234,456 - Filed: 2023-08-16 - Granted: 2024-06-04 - Earliest claimed: 2020-04-29 - Applicants: S-Alpha Therapeutics, Inc. - Inventors: Seung Eun Choi; Yong Sun Lee; Ja Rang Hahm - Web page: https://patentgrep.com/patent/US11998742B1 ## CPC - G16H 20/30: relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising - A61B 5/4833: {Assessment of subject's compliance to treatment} - A61N 1/36053: {adapted for vagal stimulation (A61N1/36114 takes precedence)} - A61N 1/3606: {adapted for a particular treatment} - G16H 20/70: relating to mental therapies, e.g. psychological therapy or autogenous training - G16H 40/63: for local operation - G16H 50/20: for computer-aided diagnosis, e.g. based on medical expert systems - G16H 50/30: for calculating health indices; for individual health risk assessment - G16H 50/80: for detecting, monitoring or modelling epidemics or pandemics, e.g. flu - Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change - Y02A 90/10: Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE ## Abstract The present disclosure provides systems and methods for treating a virus disease in a subject in need thereof. ## Claims ### Claim 1 A method of treating a virus disease in a subject in need thereof, the method comprising: providing a first exercise module and a first vagal nerve stimulation module, the first exercise module comprising at least one first exercise instruction selected from the group consisting of moderate, aerobic and acute exercise instructions for the subject to follow, and the first vagal nerve stimulation module comprising at least one first stimulation instruction selected from the group consisting of a sense stimulation instruction for sight, a sense stimulation instruction for sound, a sense stimulation instruction for touch, a sense stimulation instruction for taste and a sense stimulation instruction for smell for the subject to follow, thereby stimulating at least one of sympathetic nerve system and autonomic nervous system of the subject, detecting the subject's adherence to the at least one first exercise instruction and the at least one first stimulation instruction using a sensor, and providing a second exercise module and a second vagal nerve stimulation module based on the adherence information, the second exercise module comprising at least one second exercise instruction selected from the group consisting of moderate, aerobic and acute exercise instructions, and the second vagal nerve stimulation module comprising at least one second stimulation instruction selected from the group consisting of a sense stimulation instruction for sight, a sense stimulation instruction for sound, a sense stimulation instruction for touch, a sense stimulation instruction for taste and a sense stimulation instruction for smell for the subject to follow, thereby stimulating at least one of sympathetic nerve system and autonomic nervous system of the subject. ### Claim 2 (depends on 1) The method according to claim 1, wherein the method activates or increases production of natural killer (NK) cells in the subject. ### Claim 3 (depends on 1) The method according to claim 1, wherein the method reduces a change in a number of central T cells in the subject. ### Claim 4 (depends on 1) The method according to claim 1, wherein the at least one first stimulation instruction stimulates the autonomic nervous system. ### Claim 5 (depends on 1) The method according to claim 1, wherein the virus disease includes at least one of SARS, MERS, COVID-19, influenza, respiratory tract infection, or gastrointestinal infection. ### Claim 6 (depends on 1) The method according to claim 1, wherein the first exercise module and the first vagal nerve stimulation module are provided with a first lag time therebetween. ### Claim 7 (depends on 6) The method according to claim 6, wherein the first lag time is at least 3 hours. ### Claim 8 (depends on 1) The method according to claim 1, wherein the second exercise module and the second vagal nerve stimulation module are provided with a second lag time therebetween. ### Claim 9 (depends on 8) The method according to claim 8, wherein the second lag time is at least 3 hours. ### Claim 10 (depends on 1) The method according to claim 1, wherein the first exercise module is configured to provide a first moderate exercise instruction corresponding to a target heart rate, the target heart rate predetermined based on an age of the subject. ### Claim 11 (depends on 10) The method according to claim 10, comprising: measuring an optical blood flow of the subject to measure a heart rate; and adjusting the target heart rate based on the measured heart rate and the age of the subject. ### Claim 12 (depends on 11) The method according to claim 11, wherein the second exercise module and the second vagal nerve stimulation model is provided based on the adjusted target heart rate. ### Claim 13 (depends on 12) The method according to claim 12, wherein the at least one first exercise instruction comprises instructions for benchmark exercise, the benchmark exercise comprises one or more exercises selected from the group consisting of jumping jacks, squats, and pushups. ### Claim 14 A digital system for treating a virus disease of a subject, the digital system comprising: a processor configured to: provide a first exercise module and a first vagal nerve stimulation module, the first exercise module comprising at least one first exercise instruction selected from the group consisting of moderate, aerobic, and acute exercise instructions for the subject to follow, and the first vagal nerve stimulation module comprising at least one first stimulation instruction selected from the group consisting of a sense stimulation instruction for sight, a sense stimulation instruction for sound, a sense stimulation instruction for touch, a sense stimulation instruction for taste and a sense stimulation instruction for smell for the subject to follow, thereby stimulating at least one of sympathetic nerve system and autonomic nervous system of the subject, detect the subject's adherence to the at least one first exercise instruction and the at least one first stimulation instruction using a sensor, and provide a second exercise module and a second vagal nerve stimulation module based on the adherence information, the second exercise module comprising at least one second exercise instruction selected from the group consisting of moderate, aerobic, and acute exercise instructions, and the second vagal nerve stimulation module comprising at least one second stimulation instruction selected from the group consisting of a sense stimulation instruction for sight, a sense stimulation instruction for sound, a sense stimulation instruction for touch, a sense stimulation instruction for taste and a sense stimulation instruction for smell for the subject to follow, thereby stimulating at least one of sympathetic nerve system and autonomic nervous system of the subject. ### Claim 15 (depends on 14) The digital system according to claim 14, wherein the first exercise module and the second exercise module activate or increase production of natural killer (NK) cells in the subject. ### Claim 16 (depends on 14) The digital system according to claim 14, wherein the first exercise module and the second exercise module reduce a change in a number of central T cells in the subject. ### Claim 17 (depends on 14) The digital system according to claim 14, wherein the at least one first stimulation instruction stimulates the autonomic nervous system. ### Claim 18 (depends on 14) The digital system according to claim 14, wherein the virus disease includes at least one of SARS, MERS, COVID-19, influenza, respiratory tract infection, or gastrointestinal infection. ### Claim 19 A non-transitory computer readable medium storage configured to store one or more programs which, when executed by a processor, cause the processor to perform operations comprising: providing a first exercise module and a first vagal nerve stimulation module, the first exercise module comprising at least one first exercise instruction selected from the group consisting of moderate, aerobic, or acute exercise instructions for the subject to follow, and the first vagal nerve stimulation module comprising at least one first stimulation instructions selected from the group consisting of a sense stimulation instruction for sight, a sense stimulation instruction for sound, a sense stimulation instruction for touch, a sense stimulation instruction for taste and a sense stimulation instruction for smell for the subject to follow, thereby stimulating at least one of sympathetic nerve system and autonomic nervous system of the subject, detecting the subject's adherence to the at least one first exercise instruction and the at least one first stimulation instruction using a sensor, and providing a second exercise module and a second vagal nerve stimulation module based on the adherence information, the second exercise module comprising at least one second exercise instruction selected from the group consisting of moderate, aerobic and acute exercise instructions, and the second vagal nerve stimulation module comprising at least one second stimulation instructions selected from the group consisting of a sense stimulation instruction for sight, a sense stimulation instruction for sound, a sense stimulation instruction for touch, a sense stimulation instruction for taste and a sense stimulation instruction for smell for the subject to follow, thereby stimulating at least one of sympathetic nerve system and autonomic nervous system of the subject. ### Claim 20 (depends on 19) The non-transitory computer readable medium storage according to claim 19, wherein the first exercise module and the second exercise module activate or increase production of natural killer (NK) cells in the subject. ### Claim 21 (depends on 19) The non-transitory computer readable medium storage according to claim 19, wherein the first exercise module and the second exercise module reduce a change in a number of central T cells in the subject.