# US 11,998,733 B1 · Self-expanding stent including a thin-film neural interface and method of delivering a thin-film neural interface using a self-expanding stent

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- Number: US 11,998,733 B1
- Document ID: US11998733B1
- Status: Granted
- Kind: B1
- Application number: 17/385,525
- Filed: 2021-07-26
- Granted: 2024-06-04
- Earliest claimed: 2020-07-30
- Assignees: Verily Life Sciences LLC
- Applicants: Verily Life Sciences LLC
- Inventors: Kenneth Rys; Bo Lu
- Web page: https://patentgrep.com/patent/US11998733B1

## CPC

- A61N 1/0558: {Anchoring or fixation means therefor}
- A61F 2/844: folded prior to deployment
- A61F 2/89: the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
- A61F 2230/0006: circular
- A61F 2230/0008: elliptical or oval
- A61N 1/37516: {Intravascular implants}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)

## Abstract

The present disclosure relates to a medical device, methods of making a medical device, and methods of delivering medical device. Particularly, aspects of the present disclosure are directed to a medical device having a self-expanding stent and a thin-film neural interface. The stent comprises a plurality of struts having a substantially elliptical or circular geometry arranged in series from a proximal end to a distal end of the stent, and a thin-film neural interface attached to the stent. Each strut of the self-expanding stent comprises a top portion and a base portion integrally connected with the top portion at a first connection point and a second connection point such that the top portion moves relative to the base portion. The self-expanding stent provides a retracted configuration to protect the thin-film neural interface during delivery, and an expanded configuration to deploy the thin-film neural interface.

## Claims

### Claim 1

A medical device comprising:
a stent comprising:
a plurality of struts arranged in series from a proximal end to a distal end of the stent, wherein each strut of the plurality of struts comprises: a top portion, a base portion integrally connected with the top portion at a first connection point and a second connection point, a first hinge disposed at the first connection point, and a second hinge disposed at the second connection point, wherein the first hinge and the second hinge allow the top portion to move at an angle from −30° to 90° relative to the base portion;
a first cross-bar attached to the first connection point of each strut of the plurality of struts;
a second cross-bar attached to the second connection point of each strut of the plurality of struts; and
a third cross-bar attached to the top portion of each strut of the plurality of struts; and
a thin-film neural interface comprising:
a supporting structure having a first surface and a second surface opposite of the first surface; and
one or more electrodes formed on the first surface of the supporting structure, wherein the second surface of the supporting structure is attached to the base portion of each strut of the plurality of struts.

### Claim 2 (depends on 1)

The medical device of claim 1, wherein each strut of the plurality of struts have an elliptical or circular geometry.

### Claim 3 (depends on 2)

The medical device of claim 2, wherein the base portion of each strut of the plurality of struts is an arc that is less than one half of a circumference of the elliptical or circular geometry, and wherein the top portion of each strut of the plurality of struts is an arc that is greater than one half of a circumference of the elliptical or circular geometry.

### Claim 4 (depends on 3)

The medical device of claim 3, wherein the stent comprises stainless steel, Nitinol, nickel, titanium, or any combinations thereof.

### Claim 5 (depends on 1)

The medical device of claim 1, wherein the stent is a monolithic structure.

### Claim 6 (depends on 1)

The medical device of claim 1, wherein each strut of the plurality of struts is spaced a predetermined distance from adjacent struts of the plurality of struts.

### Claim 7 (depends on 6)

The medical device of claim 6, wherein the predetermined distance is at least 0.5 mm.

### Claim 8 (depends on 1)

The medical device of claim 1, wherein the thin-film neural interface further comprises a wiring layer formed on the supporting structure, and the one or more electrodes are electrically connected to the wiring layer, and wherein the supporting structure comprises one or more layers of dielectric material.

### Claim 9 (depends on 8)

The medical device of claim 8, wherein the dielectric material is liquid crystal polymer.

### Claim 10 (depends on 8)

The medical device of claim 8, further comprising:
a cable comprising:
the supporting structure comprised of the dielectric material;
one or more conductive traces formed on the supporting structure and electrically connected with the wiring layer; and
one or more encapsulation layers encasing at least a portion of the supporting structure.

### Claim 11 (depends on 10)

The medical device of claim 10, wherein the cable further comprises a proximal end and a distal end, and the thin-film neural interface is disposed at the distal end of the cable.

### Claim 12 (depends on 11)

The medical device of claim 11, further comprising:
a connector disposed at the proximal end of the cable and electrically connected to the one or more conductive traces; and
a neurostimulator or computing device electrically connected with the one or more electrodes via the connector, the one or more conductive traces, and the wiring layer.

### Claim 13 (depends on 1)

The medical device of claim 1, wherein the second surface of the supporting structure is attached to the base portion of each strut of the plurality of struts via an adhesive.
