# US 11,998,659 B2 · Bioimplant with evanescent coating film > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,998,659 B2 - Document ID: US11998659B2 - Status: Granted - Kind: B2 - Application number: 17/673,651 - Filed: 2022-02-16 - Published: 2022-08-04 - Granted: 2024-06-04 - Earliest claimed: 2006-09-08 - Assignees: KYOCERA Corporation - Applicants: Kyocera Corporation; Takao Hotokebuchi - Inventors: Takao Hotokebuchi; Iwao Noda - Web page: https://patentgrep.com/patent/US11998659B2 ## CPC - A61L 27/32: Phosphorus-containing materials, e.g. apatite - A61L 27/06: Titanium or titanium alloys - A61L 27/306: {Other specific inorganic materials not covered by A61L27/303 - A61L27/32} - A61L 27/425: {of phosphorus containing material, e.g. apatite} - A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} - A61L 2300/104: Silver, e.g. silver sulfadiazine - A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents - A61L 2300/606: Coatings - A61L 2420/02: Methods for coating medical devices - A61L 2420/04: Coatings containing a composite material such as inorganic/organic, i.e. material comprising different phases - A61L 2430/02: for reconstruction of bones; weight-bearing implants - A61L 2430/24: for joint reconstruction - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) ## Abstract To provide a bioimplant capable of controlling a rate of an antibacterial agent and an antibiotic to be eluted from the coating film. An evanescent coating film made of a calcium phosphate-based material having crystallinity of 10% to 90% is formed at a predetermined area of the bioimplant and an antibacterial agent or an antibiotic is contained in the coating film to suppress adhesion of bacteria. ## Claims ### Claim 1 A method of manufacturing a bioimplant, comprising: providing a base material of the bioimplant; mixing a calcium phosphate-based material and an inorganic antibacterial agent to provide a mixed material before forming a thermal sprayed film; and forming the thermal sprayed film on at least a part of a surface of the base material by spraying the mixed material on the at least a part of a surface of the base material, the thermal sprayed film comprising the calcium phosphate-based material supporting the inorganic antibacterial agent, wherein the inorganic antibacterial agent comprises a silver material, and wherein an evanescence period of the thermal sprayed film is configured to be a predetermined period in the range of 6 weeks to 120 months by selecting a combination of a thickness and a crystallinity of the thermal sprayed film such that silver ions are eluted during the predetermined period. ### Claim 2 (depends on 1) The method according to claim 1, further comprising heating the thermal sprayed film after the forming the thermal sprayed film on the at least the part of the surface of the base material. ### Claim 3 (depends on 1) The method according to claim 1, wherein the forming the thermal sprayed film comprises a thermal spraying method, and wherein the thermal spraying method is a plasma spraying method or a flame spraying method. ### Claim 4 (depends on 1) The method according to claim 1, wherein the calcium phosphate-based material is a compound or a mixture of two or more compounds selected from the group consisting of hydroxyapatite, alpha-tricalcium phosphate, beta-tricalcium phosphate, and tetracalcium phosphate. ### Claim 5 (depends on 1) The method according to claim 1, wherein the base material comprises a metal. ### Claim 6 (depends on 1) The method according to claim 1, wherein the silver material is a silver oxide. ### Claim 7 (depends on 1) The method according to claim 1, wherein the thermal sprayed film is in a form of an evanescent coating film. ### Claim 8 (depends on 2) The method according to claim 2, wherein the heating the thermal sprayed film to a predetermined temperature increases a crystallinity of the thermal sprayed film. ### Claim 9 (depends on 1) The method according to claim 1, wherein the bioimplant is an artificial dental root, an artificial bone, an internal fixing device or an artificial joint. ### Claim 10 A method of manufacturing a bioimplant, comprising: providing a base material of the bioimplant; spraying a mixed material containing an inorganic antibacterial agent and a calcium phosphate-based material to apply a coating film onto the base material, wherein the mixed material is provided by mixing the calcium phosphate-based material and the inorganic antibacterial agent before the spraying, and wherein the spraying comprises a thermal spraying process using a plasma spraying method or a flame spraying method, wherein the inorganic antibacterial agent comprises a silver material, and wherein an evanescence period of the coating film is configured to be a predetermined period in the range of 6 weeks to 120 months by selecting a combination of a thickness and a crystallinity of the coating film such that silver ions are eluted during the predetermined period. ### Claim 11 (depends on 10) The method according to claim 10, further comprising, applying a heating process to the mixed material after the spraying.