# US 11,998,633 B2 · Topical sol-gel composition for the treatment of dermatitis

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- Number: US 11,998,633 B2
- Document ID: US11998633B2
- Status: Granted
- Kind: B2
- Application number: 17/289,382
- Filed: 2019-10-16
- Published: 2022-01-06
- Granted: 2024-06-04
- Earliest claimed: 2018-11-09
- Assignees: Amorepacific Corporation
- Applicants: Amorepacific Corporation
- Inventors: Wonkyung Cho; Kwanghyun Shin; Joonho Choi; Kiwha Lee; Jong Hwa Roh; Miyoung Park; Youngho Park; Eunsil Park; Jaehong Park; Byoung Young Woo; Min Soo Kim; Eun Sol Ha
- Web page: https://patentgrep.com/patent/US11998633B2

## CPC

- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 31/44: Non condensed pyridines; Hydrogenated derivatives thereof
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/26: Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A61K 47/32: Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone}
- A61K 47/38: Cellulose; Derivatives thereof
- A61P 17/08: Antiseborrheics
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

One aspect of the present disclosure relates to a sol-gel composition enabling reversible sol-gel transition and, more specifically, to a sol-gel composition of which the viscosity changes by external physical force so that reversible sol-gel transition is performed.

## Claims

### Claim 1

A topical sol-gel composition, comprising
a first component comprising microcrystalline cellulose and carboxymethylcellulose sodium, wherein the first component is contained in an amount of 1 to 10 wt. %, based on the total weight of the topical sol-gel composition;
a second component that is any one selected from the group consisting of hydroxypropyl methylcellulose (HPMC), polyvinylpyrrolidone vinyl acetate (PVP VA), and a mixture thereof; and
a third component that is any one selected from the group consisting of poloxamer, polysorbate, and a mixture thereof, wherein the third component is contained in an amount of 0.5 to 5 wt. % based on a total weight of the sol-gel composition;
wherein the topical sol-gel composition comprises a polyol,
wherein the topical sol-gel composition comprises a drug, wherein the drug is (R)—N-[1-(3,5-difluoro-4-methansulfonylamino-phenyl)-ethyl]-3-(2-propyl-6-trifluoromethyl-pyridin-3-yl)-acrylamide, and
wherein the topical sol gel composition is a reversible sol gel composition that forms a sol state by application of external physical force, and has a viscosity of 50,000 cps in the gel state and a viscosity of 5,000 cps in the sol state, wherein it takes about 110 min to 120 min for formation of the gel state from the sol state when the sol state is left without application of an external physical force.

### Claim 2 (depends on 1)

The topical sol-gel composition according to claim 1, wherein the polysorbate is selected from the group consisting of polysorbate 20, polysorbate 60, polysorbate 80, and a combination thereof.

### Claim 3 (depends on 1)

The topical sol-gel composition according to claim 1, wherein the polyol is selected from the group consisting of propylene glycol, glycerin, butylene glycol, polyethylene glycol, polypropylene glycol, dipropylene glycol, pentylene glycol, sorbitol, and a combination thereof.

### Claim 4 (depends on 1)

The topical sol-gel composition according to claim 1, wherein the topical sol-gel composition further comprises a preservative.

### Claim 5 (depends on 4)

The topical sol-gel composition according to claim 4, wherein the preservative is selected from the group consisting of phenoxyethanol, 1,2-hexanediol, 1,3-propanediol, methyl propanediol, 1,2-pentanediol, 1,2-octanediol, 1,2-decanediol, 1,5-pentanediol, 1,6-hexanediol, 1,8-octanediol, 1,2-decanediol, ethylhexylglycerin, hexoxy-propan-1,2-diol, heptoxy-propan-1,2-diol, octoxy-propan-1,2-diol, 3-phenoxy-propan-1,2-diol, 3-benzyloxy-propan-1,2-diol, 3-phenylethyloxy-propan-1,2-diol, 3-phenylpropyloxy-propan-1,2-diol, 3-methylbenzyloxy-propan-1,2-diol, sorbitan caprylate, triclosan, climbazole, Octopirox (1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone, 2-aminoethanol), chitosan, farnesol, 2-butyloctanoic acid, 2-benzylheptan-1-ol, glycerol monolaurate, bis(2-pyridylthio)zinc 1,1′-dioxide, N,N′-(decane-1,10-diyldipyridin-1-yl-4-ylidene)-dioctan-1-amine dihydrochloride (octenidine dihydrochloride), thymol, eugenol, benzyl alcohol, 2-phenyethyl alcohol, 3-phenyl propanol, 1-phenoxy-propan-2-ol, 3-phenoxypropanol, benzyloxymethanol, and a combination thereof.