# US 11,998,625 B2 · Oral care compositions > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,998,625 B2 - Document ID: US11998625B2 - Status: Granted - Kind: B2 - Application number: 17/249,912 - Filed: 2021-03-18 - Published: 2021-07-08 - Granted: 2024-06-04 - Earliest claimed: 2016-12-21 - Assignees: Colgate-Palmolive Company - Applicants: Colgate-Palmolive Company - Inventors: Aarti Rege; Michael Prencipe - Web page: https://patentgrep.com/patent/US11998625B2 ## CPC - A61K 8/27: Zinc; Compounds thereof - A61K 8/19: containing inorganic ingredients - A61K 8/20: Halogens; Compounds thereof - A61K 8/21: Fluorides; Derivatives thereof - A61K 8/24: Phosphorous; Compounds thereof - A61K 8/362: Polycarboxylic acids - A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses - A61K 2800/28: Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants - A61K 2800/48: Thickener, Thickening system - A61K 2800/92: Oral administration - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract An oral care composition comprising high water oral care compositions comprising an orally acceptable carrier, zinc phosphate, a first stannous ion source (i.e., stannous fluoride), and a second stannous ion source (i.e., stannous chloride). Methods and uses for this composition are also described throughout. ## Claims ### Claim 1 A high water oral care composition comprising: an orally acceptable carrier; zinc phosphate; a first stannous ion source comprising stannous fluoride in an amount of from about 0.01% to about 5%, by weight of the oral care composition; a second stannous ion source in an amount from about 0.01% to about 5%, by weight of the oral care composition; and an organic acid buffer system comprising a carboxylic acid and one or more conjugate base salts thereof. ### Claim 2 (depends on 1) The composition according to claim 1, wherein the zinc phosphate is a preformed salt of zinc phosphate. ### Claim 3 (depends on 1) The composition according to claim 1, wherein the amount of zinc phosphate is present in an amount of from 0.05 to 10% by weight, relative to the weight of the oral care composition. ### Claim 4 (depends on 1) The composition according to claim 1, wherein the amount of the water is 10% by weight or more, relative to the weight of the oral care composition. ### Claim 5 (depends on 1) The composition according to claim 1, further comprising one or more humectants selected from sorbitol, glycerol, xylitol and propylene glycol, or combinations thereof. ### Claim 6 (depends on 1) The composition according to claim 1, further comprising one or more surfactants selected from sodium lauryl sulfate, sodium laureth sulfate, or cocamidopropyl betaine, or combinations thereof. ### Claim 7 (depends on 1) The composition according to claim 1, further comprising an effective amount of one or more alkali phosphate salts. ### Claim 8 (depends on 7) The composition according to claim 7, wherein the alkali phosphate salts comprise tetrasodium pyrophosphate or tetrapotassium pyrophosphate. ### Claim 9 (depends on 1) The composition according to claim 1, further comprising one or more sources of zinc ions in addition to the zinc phosphate. ### Claim 10 (depends on 1) The composition according to claim 1, wherein the oral care composition is a dentifrice. ### Claim 11 (depends on 1) A method of treatment or prevention of erosive tooth demineralization, gingivitis, plaque, and/or dental caries, the method comprising the application to the oral cavity of a person in need thereof the composition according to claim 1. ### Claim 12 (depends on 1) A method of (i) reducing or inhibiting formation of dental caries, (ii) reducing, repairing, or inhibiting pre-carious lesions of the enamel, (iii) reducing or inhibiting demineralization and promoting remineralization of the teeth, (iv) reducing hypersensitivity of the teeth, (v) reducing or inhibiting gingivitis, (vi) promoting healing of sores or cuts in the mouth, (vii) reducing levels of acid producing bacteria, (viii) increasing relative levels of arginolytic bacteria, (ix) inhibiting microbial biofilm formation in the oral cavity, (x) raising and/or maintaining plaque pH at levels of at least pH 5.5 following sugar challenge, (xi) reducing plaque accumulation, (xii) treating, relieving, or reducing dry mouth, (xiii) cleaning the teeth and oral cavity (xiv) reducing erosion, (xv) preventing stains and/or whitening teeth, (xvi) immunizing the teeth against cariogenic bacteria; and/or (xvii) promoting systemic health, including cardiovascular health, the method comprising applying the oral care composition according to claim 1 to the oral cavity of an individual in need thereof. ### Claim 13 (depends on 1) The composition according to claim 1, wherein the acid is citric acid, and the one or more conjugate base salts comprise monosodium citrate, disodium citrate, trisodium citrate, and combinations thereof.