# US 11,998,619 B2 · Compound, antiinflammatory drug comprising the compound and cyclooxygenase-2 inhibitor comprising the compound

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- Number: US 11,998,619 B2
- Document ID: US11998619B2
- Status: Granted
- Kind: B2
- Application number: 16/982,856
- Filed: 2019-03-22
- Published: 2021-02-25
- Granted: 2024-06-04
- Earliest claimed: 2018-03-22
- Assignees: Yong Min Chang
- Applicants: Yong Min Chang
- Inventors: Yong Min Chang; Hee Kyeong Kim; Seungtae Woo; Seonguk Jin; Sung Bo Kyung
- Web page: https://patentgrep.com/patent/US11998619B2

## CPC

- A61K 49/085: {conjugated systems}
- A61K 49/108: {the metal complex being Gd-DOTA}
- A61K 33/244: Lanthanides; Compounds thereof (medicinal preparations containing radioactive lanthanides for use in therapy or testing in vivo A61K51/00)
- A61K 47/547: {Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent}
- A61K 49/10: Organic compounds
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C07D 257/02: not condensed with other rings
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

A compound is disclosed that can be used as an anti-inflammatory agent, a cyclooxygenase-2 inhibitor, a therapeutic agent for brain diseases, or a MRI contrast medium. The compound can have the structure represented by chemical formula 1.

## Claims

### Claim 1

A method for treating brain inflammation, the method comprising administering to a patient with brain inflammation a therapeutically effective amount of a composition comprising a compound having a structure represented by a following Chemical Formula 2, 3, or 4:
to treat the brain inflammation in the subject, wherein the compound treats the brain inflammation in the subject.

### Claim 2 (depends on 1)

The method of claim 1, wherein the compound is represented by Chemical Formula 2:

### Claim 3 (depends on 1)

The method of claim 1, wherein the compound is represented by Chemical Formula 3:

### Claim 4 (depends on 1)

The method of claim 1, wherein the compound is represented by Chemical Formula 4:

### Claim 5 (depends on 1)

The method of claim 1, wherein the compound selectively inhibits cyclooxygenase-2 (COX-2) at the inflammation site.

### Claim 6

A method for treating brain inflammation, the method comprising administering to a patient with brain inflammation a therapeutically effective amount of a composition comprising a compound having a structure represented by a following compound having a structure represented by a following Chemical Formula 1:
wherein in the Chemical Formula 1, the linker represents *—(CH2)x-A-(CH2)y—*,
wherein each of x and y independently represents an integer from 0 to 5,
wherein A represents *—COO—*, *—CO—*, *—CONH—* or *—O—*,,
wherein X represents:
to treat the brain inflammation in the subject, wherein the compound treats the brain inflammation in the subject.