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AssigneesThe Secretary of State for Environment, Food and Rural Affairs, The Governors of the University of Alberta
InventorsJohn McGiven, Laurence Howells, Lucy Duncombe, David Bundle, Satadru Sekhar Mandal, Susmita Sarkar
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There is provided a molecule comprising a chain of seven or more contiguous units of 4,6-dideoxy-4-acylamido-α-pyranose each pair of units joined by a C1-C2 or a C1-C3 link, the chain having a terminal end and a reducing end, wherein the pyranose ring in the unit of the chain most distal from the reducing end is linked to a cap structure. The cap structure is not a 4,6-dideoxy-4-acylamido-α-pyranose. There are also provided vaccine compositions comprising the molecule and methods of vaccinating an animal against infection by a Brucella organism, including methods of distinguishing between a vaccinated and an infected animal. There are further provided novel methods of detecting the presence in a sample of an anti-Brucella antibody.
A diagnostic conjugate comprising a trisaccharide consisting of three units of 4,6-dideoxy-4-formamido-α-D-mannopyranose and comprising only C1-C2 links or comprising a disaccharide consisting of two units of 4,6-dideoxy-4-formamido-α-D-mannopyranose joined by a C1-C2 link, wherein the trisaccharide or disaccharide is linked to a non-saccharide carrier via the reducing end and wherein the non-saccharide carrier comprises a protein, surface, or bead that allows the detection of the presence of an antibody in a sample.
A method of detecting the presence of an anti-Brucella antibody in a sample, comprising contacting the sample with an antigen comprising a trisaccharide consisting of three units of 4,6-dideoxy-4-formamido-α-D-mannopyranose and comprising only C1-C2 links and/or with an antigen comprising a disaccharide consisting of two units of 4,6-dideoxy-4-formamido-α-D-mannopyranose joined by a C1-C2 link, wherein the trisaccharide or disaccharide is linked to a non-saccharide carrier via the reducing end and wherein the non-saccharide carrier allows the detection of the presence of the antibody in the sample.
A diagnostic conjugate comprising:
A method of detecting the presence of an anti-Brucella antibody in a sample, comprising
Dependencies are inferred from the claim text.