Compounds and methods for selective proteolysis of glucocorticoid receptors

A compound of structural Formula I

• or a salt thereof, wherein:
• E is chosen from
• L is chosen from *—(CH2)nCH2N(R7)CO(CH2)pCH2—**, *—CO(CH2)nCH2—**, *—CO(CH2)qO(CH2CH2O)nCH2(CH2)p—**, *—(CH2)nCH2—**, *—(CH2)qO(CH2CH2O)nCH2(CH2)p—**,
• represents the point of attachment to E;
• represents the point of attachment to X;
• X is chosen from O, NR10, S, SO, and SO2;
• R1 and R2 are independently chosen from H, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxy, alkenyl, alkynyl, halo, alkylamino, dialkylamino, cyano, and hydroxy;
• R3 and R4 are independently chosen from H, alkyl, alkoxy, alkenyl, alkylnyl, and hydroxyl, or
• R3 and R4, together with the atom to which they are attached, form a cycloalkyl or heterocycloalkyl ring, either of which is optionally substituted with 1, 2, or 3 R11 groups;
• R5 and R6 are independently chosen from H, alkyl, haloalkyl, alkoxy, amino, alkylamino, dialkylamino, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, (heterocycloalkyl)alkyl, CONR12R13, SO2NR12R13, SOR14, SO2R14, halo, hydroxy, and cyano, or
• R5 and R6, together with the atom to which they are attached, form a cycloalkyl or heterocycloalkyl ring, either of which is optionally substituted with 1, 2, or 3 R15 groups;
• R7 is chosen from H, alkyl, cycloalkyl, (cycloalkyl)alkyl, (CH2)tCOOH, alkylcarbonyl, and —CO(CH2)tCOOH;
• R8 and R9 are independently chosen from H, alkyl, alkylcarbonyl, cycloalkylcarbonyl, alkoxycarbonyl, alkylsulfonyl, —(CH2)tCOOH, —CO(CH2)tCOOH, —COO(CH2)tCOOH, and —(CH2)tSO2OH;
• R10 is chosen from H, alkyl, alkoxyalkyl, cycloalkyl, and heterocycloalkyl;
• each R11 is independently chosen from alkyl, cycloalkyl, heterocycloalkyl, alkoxy, cyano, halo, and hydroxy;
• each R12 and R13 is independently chosen from H, alkyl, cycloalkyl, and heterocycloalkyl;
• each R14 is independently chosen from alkyl, cycloalkyl, and heterocycloalkyl;
• each R15 is independently chosen from alkyl, cycloalkyl, heterocycloalkyl, alkoxy, cyano, halo, and hydroxy;
• n and p are independently chosen from 0-11, inclusive;
• q is chosen from 0-11, inclusive;
• r and s are independently chosen from 1-4, inclusive;
• and
• t is chosen from 1-8, inclusive.