Anti-cancer plant virus particles linked to HER2 antigens
AssigneeCase Western Reserve University
InventorsNicole F. Steinmetz, Sourabh Shukla
Life of this patent
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Abstract
An anti-cancer virus composition including an icosahedral-shaped plant virus or virus-like particle linked to a HER2 antigen is described. The anti-cancer virus composition can be used for methods of treating or decreasing the risk of developing a HER2-expressing cancer in a subject by administering to a subject in need thereof an effective amount of the anti-cancer virus composition.
Claims19
An anti-cancer particle composition comprising an icosahedral-shaped plant virus or virus-like particle linked to a HER2 antigen, wherein the HER2 antigen comprises all or a portion of the amino acid sequence located between position 163 and 182 of human HER2 protein.
A method of treating or decreasing the risk of developing a HER2-expressing cancer in a subject, by comprising administering to a subject in need thereof an effective amount of an anti-cancer particle composition comprising an icosahedral-shaped plant virus or virus-like particle linked to a HER2 antigen, wherein the HER2 antigen comprises a B-cell and a T-cell epitope from the extracellular domain of HER2 epitope homologous to the species of subject being treated.
Dependencies are inferred from the claim text.