# US 11,998,582 B1 · Composition for treating bone loss

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 11,998,582 B1
- Document ID: US11998582B1
- Status: Granted
- Kind: B1
- Application number: 18/529,504
- Filed: 2023-12-05
- Granted: 2024-06-04
- Earliest claimed: 2023-12-05
- Assignees: King Faisal University
- Applicants: King Faisal University
- Inventors: Basem Mohamed Abdallah; Enas Mohamed Ali
- Web page: https://patentgrep.com/patent/US11998582B1

## CPC

- A61K 36/53: Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61P 19/10: for osteoporosis
- A61K 2236/15: involving mechanical treatment, e.g. chopping up, cutting or grinding
- A61K 2236/17: involving drying, e.g. sun-drying or wilting
- A61K 2236/31: involving untreated material, e.g. fruit juice or sap obtained from fresh plants
- A61K 2236/33: involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The composition for treating bone loss is an alcoholic extract of Lavandula atriplicifolia plant flowers and leaves. The composition is prepared by extracting dried Lavandula plant flower and leaf powder in ethanol or methanol for at least 4 hours in a Soxhlet apparatus. The Lavandula atriplicifolia extract acts by both stimulating osteogenesis and inhibiting adipogenesis. The composition may be used to form drug compositions for treating bone loss.

## Claims

### Claim 1

A composition for treating bone loss, comprising an extract of a Lavandula atriplicifolia plant and an orally acceptable carrier selected from the group consisting of a tablet, a capsule, a powder, and a suspension, wherein the extract of the Lavandula atriplicifolia plant is obtained by a method comprising:
providing fresh flowers and leaves of the Lavandula atriplicifolia plant;
drying the fresh flowers and leaves of the Lavandula atriplicifolia plant to obtain dried plant materials;
crushing the dried plant materials to obtain a plant powder; and
extracting the plant powder in a solvent using a Soxhlet apparatus to obtain a resulting extract.

### Claim 2 (depends on 1)

The composition for treating bone loss according to claim 1, wherein the extract of a Lavandula atriplicifolia plant is an extract in ethanol as an extraction solvent.

### Claim 3 (depends on 1)

The composition for treating bone loss according to claim 1, wherein the extract of a Lavandula atriplicifolia plant is an extract in methanol as an extraction solvent.

### Claim 4 (depends on 1)

The composition for treating bone loss according to claim 1, wherein the extract of a Lavandula atriplicifolia plant comprises vanillic acid, gallic acid, and hydroxycinnamic acid.

### Claim 5 (depends on 1)

The composition for treating bone loss according to claim 1, further comprising a mixture of phenolic compounds.

### Claim 6 (depends on 1)

A method for treating bone loss, comprising the step of administering to a patient in need thereof an effective amount of the composition of claim 1 for reducing bone loss.

### Claim 7 (depends on 6)

The method of claim 6, further comprising stimulating differentiation of cells into osteoblasts in the patient.

### Claim 8 (depends on 6)

The method of claim 6, further comprising inhibiting differentiation of cells into adipocytes in the patient.

### Claim 9 (depends on 6)

The method of claim 6, wherein the composition is orally administered to the patient.