# US 11,998,563 B2 · Polymeric treatment compositions

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- Number: US 11,998,563 B2
- Document ID: US11998563B2
- Status: Granted
- Kind: B2
- Application number: 17/744,192
- Filed: 2022-05-13
- Published: 2022-09-01
- Granted: 2024-06-04
- Earliest claimed: 2012-06-14
- Assignees: MicroVention, Inc.
- Applicants: MicroVention, Inc.
- Inventors: Gregory M. Cruise; Michael J. Constant; Joshua Garretson
- Web page: https://patentgrep.com/patent/US11998563B2

## CPC

- A61K 31/785: Polymers containing nitrogen
- A61K 9/0024: {Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue (compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L)}
- A61K 31/78: of acrylic acid or derivatives thereof
- A61L 24/0089: {containing inorganic fillers not covered by groups A61L24/0078 or A61L24/0084}
- A61L 24/046: {obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds (A61L24/043 takes precedence)}
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61K 47/32: Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone}
- A61L 2430/36: for embolization or occlusion, e.g. vaso-occlusive compositions or devices
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

## Claims

### Claim 1

A composition comprising:
a biocompatible polymer comprising:
a first monomer wherein the first monomer is t-butyl acrylate;
a second monomer wherein the second monomer is an alkyl acrylate comprising a hydroxyl group; and
a third monomer wherein the third monomer is hydroxyethyl methacrylate;
a pH-sensitive component, wherein the pH-sensitive component is selected from aminopropyl methacrylamide, aminoethyl methacrylamide, N-(3-methylpyridine)acrylamide, N-(2-(4-aminophenyl)ethyl)acrylamide, N-(4-aminobenzyl)acrylamide, N-(2-(4-imidazolyl)ethyl)acrylamide, derivatives thereof, and combinations thereof;
an aqueous solution with a non-physiological pH; and
a visualization agent;
wherein the biocompatible polymer is soluble in the aqueous solution and insoluble at a physiological pH at a treatment site.

### Claim 2 (depends on 1)

The composition of claim 1, wherein the visualization agent is a particulate.

### Claim 3 (depends on 1)

The composition of claim 1, wherein the visualization agent has a concentration of about 5% w/w to about 65% w/w.

### Claim 4 (depends on 1)

The composition of claim 1, wherein the visualization agent is barium sulfate or tantalum.

### Claim 5 (depends on 1)

The composition of claim 1, wherein the non-physiological pH solution is water.

### Claim 6 (depends on 1)

The composition of claim 1, wherein the non-physiological pH solution has a pH of less than about 6.

### Claim 7 (depends on 1)

The composition of claim 1, wherein the biocompatible polymer has a concentration of about 1% w/w to about 35% w/w.

### Claim 8 (depends on 1)

The composition of claim 1, wherein the biocompatible polymer further includes a polymerization initiator.

### Claim 9 (depends on 8)

The composition of claim 8, wherein the polymerization initiator is azobisisobutyronitrile.

### Claim 10 (depends on 8)

The composition of claim 8, wherein the polymerization initiator has a concentration of about 0.25% w/w to about 2% w/w.

### Claim 11 (depends on 1)

The composition of claim 1, wherein the pH-sensitive component is aminopropyl methacrylamide.