# US 11,998,559 B2 · Agent for preventing or ameliorating alzheimer's disease

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- Number: US 11,998,559 B2
- Document ID: US11998559B2
- Status: Granted
- Kind: B2
- Application number: 16/756,978
- Filed: 2018-10-03
- Published: 2021-04-29
- Granted: 2024-06-04
- Earliest claimed: 2017-10-18
- Assignees: Daicel Corporation
- Applicants: Daicel Corporation
- Inventors: Kaori Takahashi; Katsuyuki Mukai; Yasuyuki Igarashi; Kohei Yuyama
- Web page: https://patentgrep.com/patent/US11998559B2

## CPC

- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A61K 31/7032: attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
- A23L 29/244: from corms, tubers or roots, e.g. glucomannan (starch A23L29/212)
- A23L 33/115: Fatty acids or derivatives thereof; Fats or oils
- A61K 31/164: of a carboxylic acid with an aminoalcohol, e.g. ceramides
- A61K 31/7028: Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K 36/888: Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The purpose of the present invention is to provide an agent for preventing or ameliorating Alzheimer's disease, said agent being able to effectively suppress the accumulation of amyloid β proteins using a safe material, which has been used in foods for many years, and improve spontaneous alternation behavior change ratio. Ceramides (in particular, a glucosylceramide originating in Amorphophallus konjac) can effectively suppress the accumulation of amyloid β proteins and thus enables the prevention or amelioration of Alzheimers disease.

## Claims

### Claim 1

A method for ameliorating cognitive function in Alzheimer's disease to a person in need of amelioration of Alzheimer's disease and cognitive function, comprising a step of administering an effective amount of a ceramide to the person,
wherein the ceramide is derived from tuber of Amorphophallus konjac and wherein the ceramide comprises a glucosylceramide of 4,8-sphingadienine.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the ceramide is in a form of food or beverage.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the ceramide is in a form of pharmaceutical.

### Claim 4 (depends on 1)

The method according to claim 1, wherein a composition containing the ceramide with a content of 1 to 20% by mass is administered.

### Claim 5 (depends on 1)

The method according to claim 1, wherein a dosage of the ceramide is 0.6 to 10 mg per day.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the glucosylceramide is a glucosylceramide of trans-4, cis-8-sphingadienine or trans-4-trans-8-sphingadienine.

### Claim 7 (depends on 1)

The method according to claim 1, wherein a composition containing the ceramide with a content of 1 to 20% by mass is administered, and
wherein a dosage of the ceramide is 0.6 to 10 mg per day.