# US 11,998,554 B2 · Composition comprising lipoic acid and vitamin D for the prevention and the treatment of neurodegenerative diseases and peripheral neuropathies

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 11,998,554 B2
- Document ID: US11998554B2
- Status: Granted
- Kind: B2
- Application number: 17/272,623
- Filed: 2019-09-10
- Published: 2022-07-07
- Granted: 2024-06-04
- Earliest claimed: 2018-09-10
- Assignees: Uriach Italy S.R.L.
- Applicants: Uriach Italy S.R.L.
- Inventors: Lorenzo Secondini
- Web page: https://patentgrep.com/patent/US11998554B2

## CPC

- A61K 31/593: 9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
- A61K 31/385: having two or more sulfur atoms in the same ring
- A61P 25/02: for peripheral neuropathies
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61P 39/04: Chelating agents
- A61P 39/06: Free radical scavengers or antioxidants
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention regards a composition comprising lipoic acid, or an acceptable pharmaceutical or food grade salt thereof or a derivative thereof, and a vitamin D, preferably vitamin D3 and/or vitamin D2, for use in a method for the treatment of neurodegenerative diseases and/or for the treatment of peripheral neuropathies.

## Claims

### Claim 1

A method for reducing oxidative stress in an astrocyte, comprising administering to the astrocyte a composition comprising a mixture of:
(I) lipoic acid or a derivative thereof, or an acceptable pharmaceutical salt of lipoic acid or a derivative thereof;
(II) a vitamin of group D or a derivative thereof, wherein said (II) vitamin of group D is selected from among: vitamin D3 or a derivative thereof, vitamin D2 or a derivative thereof and a mixture thereof; wherein:
(a) the lipoic acid or a derivative thereof is 98% to 99.9% of the mixture by weight, and
(b) the vitamin D3 and/or vitamin D2, or a derivative thereof, is 0.001% to 1% 0.001% to 10% of the mixture by weight and, optionally, said composition comprises at least one pharmaceutical additive and/or excipient.

### Claim 2 (depends on 1)

The method of claim 1, wherein said (II) vitamin of group D is a vitamin D3 or a derivative thereof.

### Claim 3 (depends on 1)

The method of claim 1, wherein said (II) vitamin of group D is a vitamin D2 or a derivative thereof.

### Claim 4 (depends on 1)

The method of claim 1, wherein said (II) vitamin of group D is a mixture of vitamin D3 or a derivative thereof, and of vitamin D2, or a derivative thereof.

### Claim 5 (depends on 4)

The method of claim 4, wherein said mixture of vitamin D3 or a derivative thereof and of vitamin D2 or a derivative thereof is in a vitamin D3:vitamin D2 by weight ratio comprised in the range from 10:1 to 1:10.

### Claim 6 (depends on 1)

The method of claim 1, wherein said (I) lipoic acid is a racemic form of lipoic acid or acceptable pharmaceutical or food grade salt thereof or a derivative thereof.