# US 11,998,531 B1 · Pharmaceutical intermediates and methods for preparing the same in the synthesis of muscimol and congeners and derivatives thereof

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- Number: US 11,998,531 B1
- Document ID: US11998531B1
- Status: Granted
- Kind: B1
- Application number: 18/539,688
- Filed: 2023-12-14
- Granted: 2024-06-04
- Earliest claimed: 2023-12-14
- Applicants: William Allen Boulanger; Zongbo Tong
- Inventors: William Allen Boulanger; Zongbo Tong
- Web page: https://patentgrep.com/patent/US11998531B1

## CPC

- A61K 31/42: Oxazoles
- C07D 261/12: Oxygen atoms
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

Pharmaceutical intermediates and methods for efficiently preparing muscimol mono-BOC and derivatives thereof in the synthesis of muscimol and congeners and derivatives thereof.

## Claims

### Claim 1

A pharmaceutical intermediate having the structure:
wherein R1-R3 are the same or different and selected from the group consisting of H; OH; and an alkyl, cycloalkyl, polycycloalkyl, heterocycloalkyl, aryl, alkaryl, aralkyl, alkoxy, alkanoyl, aroyl, alkenyl, or alkynyl group containing 1 to 25 carbon atom(s), with the proviso that at least two of R1-R3 comprise methyl groups.

### Claim 2

A pharmaceutical intermediate having the structure: